LY3177833 monhydrate|cas:1627696-53-0|西域试剂

LY3177833 monhydrate

产品编号：Bellancom-100023A| CAS NO：1627696-53-0| 分子式：C₁₆H₁₄FN₅O₂| 分子量：327.31

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-100023A		￥1100.00	杭州北京（现货）

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LY3177833 monhydrate

产品介绍

LY3177833 (Example 4) monhydrate 是一种具有口服活性的 CDC7 和 pMCM2 的抑制剂，其 IC₅₀ 值分别为 3.3 nM 和 290 nM。LY3177833 monhydrate 是一种衰老诱导剂。

生物活性

LY3177833 (Example 4) monhydrate is an orally active CDC7 and pMCM2 inhibitor with IC₅₀ values of 3.3 nM and 290 nM, respectively. LY3177833 monhydrate is a senescence inducer.

体外研究

LY3177833 (10 μM; 4 days) increases SA-β-gal content in Hep3B cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	Hep3B cells
Concentration:	10 μM
Incubation Time:	4 days
Result:	Increased the expression of human SA-β-gal.

体内研究
(In Vivo)

LY3177833 (Example 4; 10.4-31.2 mg/kg; oral gavage; twice a day; for 2 weeks; female athymic Balb/c nude mice with SW620 cells) treatment causes significant tumor regression in a dose-dependent manner. Also, no significant tumor growth is observed for 2 weeks after dosing cessation.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female athymic Balb/c nude mice (5-6 weeks old) with SW620 cells
Dosage:	10.4 mg/kg, 20.8 mg/kg and 31.2 mg/kg
Administration:	Oral gavage; twice a day for 2 weeks
Result:	Showed dose dependent antitumor activity in SW620 mouse xenograft tumor model.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female athymic Balb/c nude mice (5-6 weeks old) with SW620 cells
Dosage:	10.4 mg/kg, 20.8 mg/kg and 31.2 mg/kg
Administration:	Oral gavage; twice a day for 2 weeks
Result:	Showed dose dependent antitumor activity in SW620 mouse xenograft tumor model.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female athymic Balb/c nude mice (5-6 weeks old) with SW620 cells
Dosage:	10.4 mg/kg, 20.8 mg/kg and 31.2 mg/kg
Administration:	Oral gavage; twice a day for 2 weeks
Result:	Showed dose dependent antitumor activity in SW620 mouse xenograft tumor model.