NMS-P515|cas:1262395-13-0|西域试剂

NMS-P515,98.18%

产品编号：Bellancom-128599| CAS NO：1262395-13-0| 分子式：C₂₁H₂₉N₃O₂| 分子量：355.47

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-128599		￥4800.00	杭州北京（现货）
Bellancom-128599		￥8000.00	杭州北京（现货）

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NMS-P515

产品介绍

NMS-P515 是有效的、口服有效的、立体定向的PARP-1 的抑制剂，K_d 值为16 nM，IC₅₀ 值为 27 nM (Hela 细胞中)。有抗肿瘤活性。

生物活性

NMS-P515 is a potent, orally active and stereospecific PARP-1 inhibitor, with a K_d of 16 nM and an IC₅₀ of 27 nM (in Hela cells). Anti-tumor activity.

体外研究

体内研究

NMS-P515 (80 mg/kg, orally daily for 12 days) exhibits potent antitumor activity in mouse models based pancreatic cancer.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Subcutaneously implanted Capan-1 pancreatic (BRCA2-mutated) mouse xenografts.
Dosage:	80 mg/kg.
Administration:	Orally, once daily for 12 days.
Result:	Clearly reduced the tumor growth (maximal tumor growth inhibition observed: 48%, maximum body weight loss: 6%).

体内研究

NMS-P515 (80 mg/kg, orally daily for 12 days) exhibits potent antitumor activity in mouse models based pancreatic cancer.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Subcutaneously implanted Capan-1 pancreatic (BRCA2-mutated) mouse xenografts.
Dosage:	80 mg/kg.
Administration:	Orally, once daily for 12 days.
Result:	Clearly reduced the tumor growth (maximal tumor growth inhibition observed: 48%, maximum body weight loss: 6%).