ORIC-101|cas:2222344-98-9|西域试剂

ORIC-101,99.30%

产品编号：Bellancom-112710| CAS NO：2222344-98-9| 分子式：C₃₄H₄₇NO₂| 分子量：501.74

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-112710		￥6200.00	杭州北京（现货）

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ORIC-101

产品介绍

ORIC-101 是一种有效、选择性的糖皮质激素受体 (glucocorticoid receptor) 拮抗剂，EC₅₀ 值为 5.6 nM。抗癌作用。

生物活性

ORIC-101 is a highly potent and selective glucocorticoid receptor antagonist, with an EC₅₀ of 5.6 nM. Anti-cancer activity.

体外研究

ORIC-101 shows markedly reduced androgen receptor agonism (EC₅₀, 2500 nM) and CYP2C8 and CYP2C9 inhibition profiles (IC₅₀, >10 μM).
ORIC-101 (1-1000 nM) dose-dependently reduces the expression of n GR-mediated target gene (FKBP5 and GILZ), with IC₅₀s of 17.2 and 21.2 nM, respectively.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

ORIC-101 (75 mg/kg, P.O. twice a day for 16-22 days) enhances the anti-tumor activity in combination with gemcitabine and carboplatin in OVCAR5 xenograft tumor in cortisol-treated mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	OVCAR5 xenograft tumor in cortisol-treated mice
Dosage:	75 mg/kg with 100 mg/kg gemcitabine and 60 mg/kg carboplatin
Administration:	P.O. twice a day for 16-22 days
Result:	Significantly reduced tumor volume in combination with chemotherapeutic agents.

体内研究

ORIC-101 (75 mg/kg, P.O. twice a day for 16-22 days) enhances the anti-tumor activity in combination with gemcitabine and carboplatin in OVCAR5 xenograft tumor in cortisol-treated mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	OVCAR5 xenograft tumor in cortisol-treated mice
Dosage:	75 mg/kg with 100 mg/kg gemcitabine and 60 mg/kg carboplatin
Administration:	P.O. twice a day for 16-22 days
Result:	Significantly reduced tumor volume in combination with chemotherapeutic agents.

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 100 mg/mL (199.31 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.9931 mL	9.9653 mL	19.9306 mL
5 mM	0.3986 mL	1.9931 mL	3.9861 mL
10 mM	0.1993 mL	0.9965 mL	1.9931 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式