Cimpuciclib tosylate|cas:2408872-84-2|西域试剂

Cimpuciclib tosylate,99.16%

产品编号：Bellancom-112243A| CAS NO：2408872-84-2| 分子式：C₃₇H₄₃FN₈O₄S| 分子量：714.85

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-112243A		￥7800.00	杭州北京（现货）
Bellancom-112243A		￥12500.00	杭州北京（现货）

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Cimpuciclib tosylate

产品介绍

Cimpuciclib tosylate 是一种选择性的 CDK4 抑制剂 (IC₅₀: 0.49 nM)，具有抗肿瘤活性。

生物活性

Cimpuciclib tosylate is a selective CDK4 inhibitor (IC₅₀: 0.49 nM) that has anti-tumor activity.

体外研究

Cimpuciclib (example 63, 141.2 nM, 6 days) tosylate inhibits proliferation of colo205 cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	Colo205 cells
Concentration:	0-500 nM approximately
Incubation Time:	6 days
Result:	Inhibited cell proliferation with an IC₅₀ value of 141.2 nM.

体内研究
(In Vivo)

Cimpuciclib (example 63, 50 mg/kg, oral gavage, twice a week) tosylate inhibits tumor growth in colo205 tumor-bearing mice.
Cimpuciclib (5 mg/kg for rats, 50 mg/kg for colo205 tumor-bearing mice, oral administration) tosylate shows slow metabolic rate and maintains high concentration in the plasma.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Colo205 tumor-bearing mice
Dosage:	50 mg/kg, twice a week
Administration:	Oral gavage
Result:	Inhibited tumor growth by 93.63%

Animal Model:

Rats, colo205 tumor-bearing mice

Dosage:

5 mg/kg for rats, 50 mg/kg for colo205 tumor-bearing mice.

Administration:

Oral administration

Result:

Pharmacokinetic profile of Cimpuciclib (example 63).

dose	C_max (ng/mL)	T_max (h)	AUC_0-24 (ng/mL•h)	t_1/2 (h)
5 mg/kg (rats)	559.7	6	5414	2.4
50 mg/kg (mice)	7960	1	136782	14.8

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Colo205 tumor-bearing mice
Dosage:	50 mg/kg, twice a week
Administration:	Oral gavage
Result:	Inhibited tumor growth by 93.63%

Animal Model:

Rats, colo205 tumor-bearing mice

Dosage:

5 mg/kg for rats, 50 mg/kg for colo205 tumor-bearing mice.

Administration:

Oral administration

Result:

Pharmacokinetic profile of Cimpuciclib (example 63).

dose	C_max (ng/mL)	T_max (h)	AUC_0-24 (ng/mL•h)	t_1/2 (h)
5 mg/kg (rats)	559.7	6	5414	2.4
50 mg/kg (mice)	7960	1	136782	14.8

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Colo205 tumor-bearing mice
Dosage:	50 mg/kg, twice a week
Administration:	Oral gavage
Result:	Inhibited tumor growth by 93.63%

Animal Model:

Rats, colo205 tumor-bearing mice

Dosage:

5 mg/kg for rats, 50 mg/kg for colo205 tumor-bearing mice.

Administration:

Oral administration

Result:

Pharmacokinetic profile of Cimpuciclib (example 63).

dose	C_max (ng/mL)	T_max (h)	AUC_0-24 (ng/mL•h)	t_1/2 (h)
5 mg/kg (rats)	559.7	6	5414	2.4
50 mg/kg (mice)	7960	1	136782	14.8

性状

Solid

溶解性数据

In Vitro:

DMSO : 200 mg/mL (279.78 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.3989 mL	6.9945 mL	13.9889 mL
5 mM	0.2798 mL	1.3989 mL	2.7978 mL
10 mM	0.1399 mL	0.6994 mL	1.3989 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献