ZZW-115|cas:801991-87-7|西域试剂

ZZW-115

产品编号：Bellancom-111838| CAS NO：801991-87-7| 分子式：C₂₄H₃₁F₃N₄S| 分子量：464.59

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货号	价格	库存与货期
Bellancom-111838	￥3500.00	杭州北京（现货）
Bellancom-111838	￥5800.00	杭州北京（现货）
Bellancom-111838	￥16500.00	杭州北京（现货）
Bellancom-111838	￥25500.00	杭州北京（现货）

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ZZW-115

产品介绍

ZZW-115 是一种有效的 NUPR1 抑制剂，K_d 为 2.1 μM，通过坏死和凋亡 (apoptosis) 诱导肿瘤细胞死亡。具有抗癌活性。

生物活性

ZZW-115 is a potent NUPR1 inhibitor, with a K_d of 2.1 μM. ZZW-115 induces tumor cell death by necroptosis and apoptosis. Anticancer activity.

体外研究

ZZW-115 (0.1-33 μM; 72 hours) is efficient in killing cancer cells, with an IC₅₀ in the range of 0.84 μM (ANOR) to 4.93 μM (HN14).
ZZW-115 (0-100 μM; 24-72 hours) is efficient to kill these tumor cells with an IC₅₀ in the range of 0.42 μM (Hep2G cells) to 7.75 μM (SaOS-2 cells).
ZZW-115 induces pancreatic cell death by necrosis and apoptosis. ZZW-115 treatment induces a decrease in ATP production and induces a ROS overproduction.
LDH release is significantly higher in ZZW-115-treated cells (MiaPaCa-2, 02-063, LIPC, Foie8b, and HN14 cells) than in control cells in a concentration-dependent manner. Similarly, caspase 3/7 activity is also greater in ZZW-115-treated cells. These experiments demonstrated that ZZW-115 exerted both pronecrotic and proapoptotic effects.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	ANOR cells, MiaPaCa-2, 02-063, 01008, LIPC, 02136, HN01,01046, AOIPC, Foie8b, HN14 cells
Concentration:	0.1- 33 μM
Incubation Time:	72 hours
Result:	Was efficient in killing cancer cells, with an IC₅₀ in the range of 0.84 μM (ANOR) to 4.93 μM (HN14).

Cell Proliferation Assay

Cell Line:	U87, A375, U2OS, SaOS-2, HT29, SK-CO-1, LS174T, H1299 and H358, HepG2, PC3, THP-1, Daudi, Jurkat and MDA-MB-231 cells
Concentration:	0-100 μM
Incubation Time:	24 or 72 hours
Result:	Was efficient to kill these tumor cells with an IC₅₀ in the range of 0.42 μM (Hep2G cells) to 7.75 μM (SaOS-2 cells).

体内研究
(In Vivo)

ZZW-115 (0.5-5 mg/kg; injection; daily for 30 days) inhibits the growth of pancreatic xenografted tumors.
ZZW-115 (5 mg/kg for 30 days; immunocompetent C57BL/6 mice were orthotopically implanted with Panc02 cells) treatment shows the tumor size is almost unmeasurable in some cases.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	NMRI-Foxn1nu/Foxn1nu mice (nude mice) xenografted with MiaPaCa-2 cells
Dosage:	5, 2.5, 1.0, or 0.5 mg/kg
Administration:	Injection, daily for 30 days
Result:	When the mice were injected with 5 mg/kg ZZW-115, the tumors stopped growing a few days after treatment and their size decreased progressively, almost disappearing at the end of the treatment.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	NMRI-Foxn1nu/Foxn1nu mice (nude mice) xenografted with MiaPaCa-2 cells
Dosage:	5, 2.5, 1.0, or 0.5 mg/kg
Administration:	Injection, daily for 30 days
Result:	When the mice were injected with 5 mg/kg ZZW-115, the tumors stopped growing a few days after treatment and their size decreased progressively, almost disappearing at the end of the treatment.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	NMRI-Foxn1nu/Foxn1nu mice (nude mice) xenografted with MiaPaCa-2 cells
Dosage:	5, 2.5, 1.0, or 0.5 mg/kg
Administration:	Injection, daily for 30 days
Result:	When the mice were injected with 5 mg/kg ZZW-115, the tumors stopped growing a few days after treatment and their size decreased progressively, almost disappearing at the end of the treatment.