MI-192|cas:1415340-63-4|西域试剂

MI-192,99.0%

产品编号：Bellancom-110264| CAS NO：1415340-63-4| 分子式：C₂₄H₂₁N₃O₂| 分子量：383.44

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-110264		￥2500.00	杭州北京（现货）

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MI-192

产品介绍

MI-192 是一种选择性 HDAC2 和 HDAC3 抑制剂，IC₅₀ 分别为 30 nM 和 16 nM。MI-192 对 HDAC2/3 的选择性比其他 HDAC 异构体更高。MI-192 诱导髓系白血病细胞凋亡 (apoptosis)。抗癌和神经保护活性。

生物活性

MI-192 is a selective HDAC2 and HDAC3 inhibitor with IC₅₀s of 30 nM and 16 nM, respectively. MI-192 is more selective for HDAC2/3 than other HDAC isomers.MI-192 induces myeloid leukaemic cells apoptosis. Anticaner and neuroprotective activities.

体外研究

MI-192 (0.15-1 μM; 72 h) induces differentiation and is cytotoxic through promotion of apoptosis in acute myeloid leukaemic cell lines U937, HL60 and Kasumi-1.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis

Cell Line:	HL60 and Kasumi-1 cells
Concentration:	150 nM, 300 nM, 500 nM, 1 μM
Incubation Time:	72 h
Result:	Induced a substantial degree of apoptosis in both HL60 and Kasumi-1 cells.

体内研究
(In Vivo)

MI-192 (40 mg/kg; i.p; once a day; for 3 days) shows the neuroprotective activity in the mouse brain subjected to photothrombotic stroke.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult male outbred mice CD-1 (20-25 g) with photothrombotic stroke (PTS)
Dosage:	40 mg/kg
Administration:	i.p; once a day; for 3 days
Result:	Reduced the volume of the PTS-induced infarction core in the mouse brain, partly restored the functional symmetry in the forelimb use, decreased the level of PTS-induced apoptosis and acetylation of α-tubulin characteristic for stable microtubules, and increased the expression of GAP-43 in the cerebral cortex of the damaged hemisphere.

体内研究

MI-192 (40 mg/kg; i.p; once a day; for 3 days) shows the neuroprotective activity in the mouse brain subjected to photothrombotic stroke.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult male outbred mice CD-1 (20-25 g) with photothrombotic stroke (PTS)
Dosage:	40 mg/kg
Administration:	i.p; once a day; for 3 days
Result:	Reduced the volume of the PTS-induced infarction core in the mouse brain, partly restored the functional symmetry in the forelimb use, decreased the level of PTS-induced apoptosis and acetylation of α-tubulin characteristic for stable microtubules, and increased the expression of GAP-43 in the cerebral cortex of the damaged hemisphere.

体内研究

MI-192 (40 mg/kg; i.p; once a day; for 3 days) shows the neuroprotective activity in the mouse brain subjected to photothrombotic stroke.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult male outbred mice CD-1 (20-25 g) with photothrombotic stroke (PTS)
Dosage:	40 mg/kg
Administration:	i.p; once a day; for 3 days
Result:	Reduced the volume of the PTS-induced infarction core in the mouse brain, partly restored the functional symmetry in the forelimb use, decreased the level of PTS-induced apoptosis and acetylation of α-tubulin characteristic for stable microtubules, and increased the expression of GAP-43 in the cerebral cortex of the damaged hemisphere.