MKC-1 Ro-31-7453|cas:125313-92-0|西域试剂

MKC-1 Ro-31-7453,99.23%

产品编号：Bellancom-13691| CAS NO：125313-92-0| 分子式：C₂₂H₁₆N₄O₄| 分子量：400.39

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货号	价格	库存与货期
Bellancom-13691	￥2600.00	杭州北京（现货）
Bellancom-13691	￥3800.00	杭州北京（现货）
Bellancom-13691	￥8000.00	杭州北京（现货）
Bellancom-13691	￥12800.00	杭州北京（现货）

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MKC-1 Ro-31-7453

产品介绍

MKC-1 (Ro-31-7453) 是一种口服有效的细胞周期抑制剂，具有广泛的抗肿瘤活性。MKC-1 抑制 Akt/mTOR 通路。通过结合一系列不同的细胞蛋白，包括微管蛋白 (tubulin) 和导入蛋白 β (importin β) 家族成员，MKC-1 阻止细胞有丝分裂并诱导细胞凋亡 (apoptosis)。

生物活性

MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family.

体外研究

体内研究

MKC-1 (200 mg/kg, orally, daily) significantly increased the median survival time (MST) of mice bearing Caki-1 renal cell xenograft tumors.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

MKC-1 (200 mg/kg, orally, daily) significantly increased the median survival time (MST) of mice bearing Caki-1 renal cell xenograft tumors.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 50 mg/mL (124.88 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.4976 mL	12.4878 mL	24.9756 mL
5 mM	0.4995 mL	2.4976 mL	4.9951 mL
10 mM	0.2498 mL	1.2488 mL	2.4976 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式