CMC2.24 TRB-N0224|cas:1255639-43-0|西域试剂

CMC2.24 TRB-N0224,96.48%

产品编号：Bellancom-120793| CAS NO：1255639-43-0| 分子式：C₂₆H₂₁NO₅| 分子量：427.45

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-120793	￥3000.00	杭州北京（现货）
Bellancom-120793	￥5000.00	杭州北京（现货）
Bellancom-120793	￥9500.00	杭州北京（现货）
Bellancom-120793	￥15500.00	杭州北京（现货）
Bellancom-120793	￥23500.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

CMC2.24 TRB-N0224

产品介绍

CMC2.24 (TRB-N0224) 是一种口服活性三羰基甲烷制剂，通过抑制 Ras 及其下游效应子 ERK1/2 途径对小鼠胰腺肿瘤有效。CMC2.24 也是一种有效的锌依赖性 MMPs 抑制剂，IC₅₀ 范围为 2.0-69 μM。CMC2.24 通过恢复软骨内稳态和通过NF-κB/HIF-2α 轴抑制软骨细胞凋亡来减轻骨关节炎的进展。

生物活性

CMC2.24 (TRB-N0224), an orally active tricarbonylmethane agent, is effective against pancreatic tumor in mice by inhibiting Ras activation and its downstream effector ERK1/2 pathway. CMC2.24 is also a potent inhibitor of zinc-dependent MMPs with IC₅₀s ranging from 2.0-69 μM. CMC2.24 alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-κB/HIF-2α axis.

体外研究

CMC2.24 (0-60 μM; 24 hours) inhibits pancreatic cancer growth in vitro.
CMC2.24 reduces STAT3^Ser727 phosphorylation levels, induces mitochondrial reactive oxygen species and mitochondrial cell death in pancreatic cancer cells. CMC2.24 induces mitochondrial reactive oxygen species and intrinsic apoptosis.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	AsPC-1, Panc-1, MIA PaCa-2 and BxPC-3 PC cells
Concentration:	0-60 μM
Incubation Time:	24 hours
Result:	Inhibits PC cell growth in a concentration-dependent manner.

体内研究
(In Vivo)

CMC2.24 (50 mg/kg; p.o.; five times per week during 17 days) inhibits the growth of pancreatic cancer xenografts.
CMC2.24 inhibits the growth of human PC through a strong cytokinetic effect. CMC2.24 inhibits ERK signaling pathway in PC cells and xenografts.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female immune deficient BALB/c nude mice
Dosage:	50 mg/kg
Administration:	P.o.; five times per week during 17 days
Result:	Reduced the rate of growth over baseline by 66.9%.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female immune deficient BALB/c nude mice
Dosage:	50 mg/kg
Administration:	P.o.; five times per week during 17 days
Result:	Reduced the rate of growth over baseline by 66.9%.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female immune deficient BALB/c nude mice
Dosage:	50 mg/kg
Administration:	P.o.; five times per week during 17 days
Result:	Reduced the rate of growth over baseline by 66.9%.