MRT68921 dihydrochloride|cas:2080306-21-2|西域试剂

MRT68921 dihydrochloride,99.58%

产品编号：Bellancom-100006A| CAS NO：2080306-21-2| 分子式：C₂₅H₃₆Cl₂N₆O| 分子量：507.50

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货号	价格	库存与货期
Bellancom-100006A	￥600.00	杭州北京（现货）
Bellancom-100006A	￥1000.00	杭州北京（现货）
Bellancom-100006A	￥2200.00	杭州北京（现货）
Bellancom-100006A	￥3900.00	杭州北京（现货）
Bellancom-100006A	￥5400.00	杭州北京（现货）

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MRT68921 dihydrochloride

产品介绍

MRT68921 dihydrochloride 是 ULK1 和 ULK2 有效的抑制剂，IC₅₀ 值分别为 2.9 nM和 1.1 nM。

生物活性

MRT68921 dihydrochloride is a potent inhibitor of ULK1 and ULK2, with IC₅₀ values of 2.9 nM and 1.1 nM, respectively.

体外研究

ULK1, a serine/threonine protein kinase, is essential for the initial stages of autophagy. MRT68921 inhibits ULK1 and ULK2 in vitro and block autophagy in cells. MRT68921 is the most potent inhibitor of both ULK1 and ULK2, with greater than a 15-fold reduction in the IC₅₀ for ULK1 (2.9 nm) and greater than a 30-fold reduction for ULK2 (1.1 nm). Autophagy-inhibiting capacity of the compounds is specifically through ULK1. ULK1 inhibition results in accumulation of stalled early autophagosomal structures, indicating a role for ULK1 in the maturation of autophagosomes as well as initiation.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

H₂O : 31.25 mg/mL (61.58 mM; Need ultrasonic)

DMSO : 8.33 mg/mL (16.41 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.9704 mL	9.8522 mL	19.7044 mL
5 mM	0.3941 mL	1.9704 mL	3.9409 mL
10 mM	0.1970 mL	0.9852 mL	1.9704 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献