CWI1-2|cas:2408590-36-1|西域试剂

CWI1-2,98.00%

产品编号：Bellancom-153274| CAS NO：2408590-36-1| 分子式：C₂₂H₁₇Cl₃N₆O₃| 分子量：519.77

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货号	价格	库存与货期
Bellancom-153274	￥1300.00	杭州北京（现货）
Bellancom-153274	￥2200.00	杭州北京（现货）
Bellancom-153274	￥4800.00	杭州北京（现货）
Bellancom-153274	￥7800.00	杭州北京（现货）
Bellancom-153274	￥12500.00	杭州北京（现货）

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CWI1-2

产品介绍

CWI1-2 是一种 IGF2BP2 抑制剂，结合 IGF2BP2 并抑制其与 m6A 修饰的靶转录物的相互作用，可诱导细胞凋亡 (apoptosis)和分化，显示出良好的抗白血病作用。

生物活性

CWI1-2 is an IGF2BP2 inhibitor that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts, induces apoptosis and differentiation, and shows promising anti-leukemic effects.

体外研究

CWI1-2 (0-1 μM, 24 h) 具有良好的抗白血病功效。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis

Cell Line:	MonoMac6, MOLM13
Concentration:	0-1 μM
Incubation Time:	24 h
Result:	Induced significant cell differentiation and apoptosis in a concentration-dependent manner in IGF2BP2-high cells but not in IGF2BP2-low cells. Reduced Gln uptake and impaired mitochondrial function, resulting in reduced ATP production in AML cells. Significantly inhibited the colony-forming ability of MA9-induced leukemic mouse blasts and greatly impairs the self-renewal of LSC/LIC.

体内研究
(In Vivo)

CWI1-2（5 mg/kg，i.v.，每日一次，7-10天）可显着延缓 BMT 受体 B6.SJL（CD45.1）小鼠白血病的发生和存活时间，体重无明显影响。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

CWI1-2（5 mg/kg，i.v.，每日一次，7-10天）可显着延缓 BMT 受体 B6.SJL（CD45.1）小鼠白血病的发生和存活时间，体重无明显影响。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

CWI1-2（5 mg/kg，i.v.，每日一次，7-10天）可显着延缓 BMT 受体 B6.SJL（CD45.1）小鼠白血病的发生和存活时间，体重无明显影响。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

参考文献

. Hengyou Weng, et al. The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia. Cancer Cell. 2022 Dec 12;40(12):1566-1582.e10. [Content Brief]

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