Moracin P is a 2-arylbenzofuran isolated from the Mori Cortex Radicis. Moracin P exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1). Moracin P reduces oxygen-glucose deprivation (OGD)-induced reactive oxygen species (ROS) production. Moracin P has neuroprotective and anti-inflammatory effects.

Moracin P enhances cell viability in dose-dependent manner against oxygen-glucose deprivation (OGD)-induced cell death in neuroblastoma SH-SY5Y cells with an EC₅₀ value of 10.4 μM. Moracin P reduces ROS production in OGD-induced cell death (IC₅₀ values of 1.9 μM). Consequently, reactive oxygen species (ROS) are overexpressed in OGD-induced cells and Moracin P reduces ROS induced by OGD in dosedependent manner.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

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