Limonene is a monoterpene in citrus peel oil. A popular disinfectant and food preservative. Antimicrobial activities. Anti-proliferative activities. Antioxidant and anti-inflammatory effect.

Acute toxicity to limonene is largely due to the common oxidation product limonene-hydroperoxide. The mutant protein AhpCL177Q 35 is able to alleviate this toxicity by reducing the hydroperoxide to a more benign compound.

Limonene exerts anti-proliferative action on a lymphoma cell line without modifying normal lymphocyte viability.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Limonene (50-100 mg/kg) exerts gastroprotection through local mucosal defense mechanisms, such as increasing the mucus production, modulation of the oxidative stress and inflammatory response and inhibition of Nf-κb expression.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Limonene (50-100 mg/kg) exerts gastroprotection through local mucosal defense mechanisms, such as increasing the mucus production, modulation of the oxidative stress and inflammatory response and inhibition of Nf-κb expression.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

• . Chubukov V, et al. Acute Limonene Toxicity in Escherichia coli Is Caused by Limonene Hydroperoxide and Alleviated by a Point Mutation in Alkyl Hydroperoxidase AhpC. Appl Environ Microbiol. 2015 Jul;81(14):4690-6.  [Content Brief]

  . Roberto D, et al. Antioxidant activity of limonene on normal murine lymphocytes: relation to H2O2 modulation and cell proliferation. Basic Clin Pharmacol Toxicol. 2010 Jan;106(1):38-44.  [Content Brief]

  . de Souza MC, et al. Gastroprotective effect of limonene in rats: Influence on oxidative stress, inflammation and gene expression. Phytomedicine. 2018 Sep 4;53:37-42.  [Content Brief]