Bax activator-1|cas:1638526-94-9|西域试剂

Bax activator-1,98.45%

产品编号：Bellancom-122760| CAS NO：1638526-94-9| 分子式：C₂₉H₃₆N₄O₃| 分子量：488.62

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货号	价格	库存与货期
Bellancom-122760	￥6380.00	杭州北京（现货）
Bellancom-122760	￥10200.00	杭州北京（现货）
Bellancom-122760	￥21400.00	杭州北京（现货）
Bellancom-122760	￥34280.00	杭州北京（现货）

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Bax activator-1

产品介绍

Bax activator-1 (compound 106) 是一种 Bax 激活剂，诱导 Bax 依赖性肿瘤细胞凋亡。

生物活性

Bax activator-1 (compound 106) is a Bax activator that induces Bax-dependent tumor cell apoptosis.

体外研究

Bax activator-1 (20-80 μM; 48 hours) induces Bax-dependent tumor cell apoptosis in a dose-dependent fashion.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis

Cell Line:	Lewis Lung Carcinoma tumor cells, human non-small cell lung carcinoma A549 cells, human pancreatic carcinoma Panc-1 cells
Concentration:	20 μM, 40 μM , 60 μM , 80 μM
Incubation Time:	48 hours
Result:	Induced apoptotic cell death in the murine Lewis Lung Carcinoma (LLC), human non-small cell lung carcinoma A549 cells and PANC-1 human pancreatic carcinoma cells in a dose-dependent fashion.

体内研究
(In Vivo)

Bax activator-1 (40 mg/kg; given i.p., each day for 13 days) inhibits lung tumor growth in C57BL/6 female mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Eight-week old C57BL/6 female mice (with Lewis Lung Carcinoma tumor cells)
Dosage:	40 mg/kg
Administration:	Given i.p., each day for 13 days
Result:	Exhibited anti-tumor activity as a single-agent.

体内研究

Bax activator-1 (40 mg/kg; given i.p., each day for 13 days) inhibits lung tumor growth in C57BL/6 female mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Eight-week old C57BL/6 female mice (with Lewis Lung Carcinoma tumor cells)
Dosage:	40 mg/kg
Administration:	Given i.p., each day for 13 days
Result:	Exhibited anti-tumor activity as a single-agent.

体内研究

Bax activator-1 (40 mg/kg; given i.p., each day for 13 days) inhibits lung tumor growth in C57BL/6 female mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Eight-week old C57BL/6 female mice (with Lewis Lung Carcinoma tumor cells)
Dosage:	40 mg/kg
Administration:	Given i.p., each day for 13 days
Result:	Exhibited anti-tumor activity as a single-agent.

性状

Solid

溶解性数据

In Vitro:

DMSO : 250 mg/mL (511.65 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.0466 mL	10.2329 mL	20.4658 mL
5 mM	0.4093 mL	2.0466 mL	4.0932 mL
10 mM	0.2047 mL	1.0233 mL	2.0466 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.08 mg/mL (4.26 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (4.26 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.08 mg/mL (4.26 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (4.26 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.08 mg/mL (4.26 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (4.26 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。