Tricetin 三粒小麦黄酮|cas:520-31-0|西域试剂

Tricetin 三粒小麦黄酮,97.0%

产品编号：Bellancom-131592| CAS NO：520-31-0| 分子式：C₁₅H₁₀O₇| 分子量：302.24

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-131592		￥7500.00	杭州北京（现货）

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Tricetin 三粒小麦黄酮

产品介绍

Tricetin 是一种有效的竞争性 Keap1-Nrf2 蛋白相互作用 (PPI) 抑制剂。Tricetin 作用于帕金森病模型，通过激活 Nrf2/HO-1 信号通路和阻止线粒体依赖性细胞凋亡 (apoptosis) 通路来保护 6-OHDA 诱导的神经毒性。

生物活性

Tricetin is a potent competitive inhibitor of the Keap1-Nrf2 Protein Protein Interaction (PPI). Tricetin protects against 6-OHDA-induced neurotoxicity in Parkinson's disease model by activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway.

体外研究

Tricetin is mainly found in natural plants such as Ginkgo biloba L., Carica papaya L. and Murraya exotica L. Tricetin activates the Nrf2/HO-1 pathway to protect cells from oxidative stress. Tricetin possessed the protective effect on dopamine neurons of C. elegans. Tricetin has cytostatic properties and anti-metastatic activity of various solid tumors.
Pretreatment with Tricetin (20, 40, and 80 μM; for 4 hours) significantly improves 6-OHDA (200 μM)-induced SH-SY5Y cells viability and suppresses mitochondria-mediated apoptosis.
Tricetin (80 μM; for 1, 2 and 4 h) markedly decreased the expressions of p-JNK and p-p38.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	SH-SY5Y cells
Concentration:	20, 40, and 80 μM
Incubation Time:	Pretreatment for 4 h followed by 6-OHDA (200 μM) for 24 h
Result:	Significantly increased 6-OHDA-induced SH-SY5Y cells viability.