KH-3|cas:1215115-03-9|西域试剂

KH-3

产品编号：Bellancom-134601| CAS NO：1215115-03-9| 分子式：C₂₁H₂₂N₂O₄S₂| 分子量：430.54

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货号	价格	库存与货期
Bellancom-134601	￥3200.00	杭州北京（现货）
Bellancom-134601	￥5500.00	杭州北京（现货）
Bellancom-134601	￥12000.00	杭州北京（现货）

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KH-3

产品介绍

KH-3 是一种有效的 RNA 结合蛋白 Hu 抗原 R (HuR) 抑制剂，其 IC₅₀ 值为 0.35 μM 。KH-3 具有抗增殖活性。KH-3 通过干扰 HuR-FOXQ1 Mrna 相互作用抑制乳腺癌细胞侵袭并延迟肺集落的形成。

生物活性

KH-3 is a potent RNA-binding protein Hu antigen R (HuR) inhibitor with an IC₅₀ value of 0.35 μM. KH-3 has anti-proliferative activity. KH-3 suppresses breast cancer cell invasion as well as delays the initiation of lung colonies by disrupting HuR-FOXQ1 mRNA interaction.

体外研究

KH-3 (0-100 μM; 48 h; human breast cancer cell lines) blocks HuR function through decrease Bcl-2, Mis2 and XIAP mRNA levels and inhibits breast cancer cells growth in a dose dependent manner.
KH-3 (0-10 μM; 0-24 h; MDA-MB-231 and SUM159 cells) inhibits breast cancer cell migration and invasion in a dose dependent manner.
KH-3 (0-10 μM; MDA-MB-231 and SUM159 cells) inhibits the interaction between HuR and FOXQ1 mRNA and decreases the amount of HuR protein pulled down by biotinylated ARE^FOXQ1 RNA oligomer.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	MDA-MB-231 cells
Concentration:	5 and 10 μM
Incubation Time:	48 hours
Result:	Reduced the protein expression levels of Bcl-2, Msi2 and XIAP.

体内研究
(In Vivo)

KH-3 (100 mg/kg; i.p.; three times a week for three weeks; female athymic NCr-nu/nu mice and BALB/c mice) inhibits breast cancer growth and metastasis in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female athymic NCr-nu/nu mice of MDA-MB-231 orthotopic xenograft and BALB/c mice of MDA-MB-231 orthotopic xenograft
Dosage:	100 mg/kg
Administration:	Intraperitoneal injection; three times a week for three weeks
Result:	Inhibited tumor growth, resulting in 60% tumor regression after three-week treatment and delayed the initiation of pulmonary metastases. Reduced the protein expression levels of HuR targets in tumor tissues as well as the induction of E-cadherin expression.

体内研究

KH-3 (100 mg/kg; i.p.; three times a week for three weeks; female athymic NCr-nu/nu mice and BALB/c mice) inhibits breast cancer growth and metastasis in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female athymic NCr-nu/nu mice of MDA-MB-231 orthotopic xenograft and BALB/c mice of MDA-MB-231 orthotopic xenograft
Dosage:	100 mg/kg
Administration:	Intraperitoneal injection; three times a week for three weeks
Result:	Inhibited tumor growth, resulting in 60% tumor regression after three-week treatment and delayed the initiation of pulmonary metastases. Reduced the protein expression levels of HuR targets in tumor tissues as well as the induction of E-cadherin expression.

体内研究

KH-3 (100 mg/kg; i.p.; three times a week for three weeks; female athymic NCr-nu/nu mice and BALB/c mice) inhibits breast cancer growth and metastasis in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female athymic NCr-nu/nu mice of MDA-MB-231 orthotopic xenograft and BALB/c mice of MDA-MB-231 orthotopic xenograft
Dosage:	100 mg/kg
Administration:	Intraperitoneal injection; three times a week for three weeks
Result:	Inhibited tumor growth, resulting in 60% tumor regression after three-week treatment and delayed the initiation of pulmonary metastases. Reduced the protein expression levels of HuR targets in tumor tissues as well as the induction of E-cadherin expression.