cRIPGBM chloride|cas:2361988-77-2|西域试剂

cRIPGBM chloride,99.73%

产品编号：Bellancom-115630| CAS NO：2361988-77-2| 分子式：C₂₆H₂₀ClFN₂O₂| 分子量：446.90

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货号	价格	库存与货期
Bellancom-115630	￥960.00	杭州北京（现货）
Bellancom-115630	￥1560.00	杭州北京（现货）
Bellancom-115630	￥3240.00	杭州北京（现货）
Bellancom-115630	￥5160.00	杭州北京（现货）
Bellancom-115630	￥8160.00	杭州北京（现货）

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cRIPGBM chloride

产品介绍

cRIPGBM chloride 是一种口服有效的促凋亡衍生物，cRIPGBM 可从多形性胶质母细胞瘤 (GBM) 癌症干细胞 (CSC) 中产生。cRIPGBM chloride 靶向受体相互作用蛋白激酶 2 (RIPK2) 以诱导半胱天冬酶 caspase 1 依赖性细胞凋亡。cRIPGBM chloride 抑制 RIPK2/TAK1 (促存活复合物) 的形成，并增加 RIPK2/caspase 1 (促凋亡复合物) 的形成。cRIPGBM chloride 在动物模型中发挥了强力的体内抗肿瘤活性。

生物活性

cRIPGBM chloride, an orally active, proapoptotic derivative. cRIPGBM can be generated from glioblastoma multiforme (GBM) cancer stem cells (CSCs). cRIPGBM(chloride) targets to receptor-interacting protein kinase 2 (RIPK2) to induce caspase 1-dependent apoptosis. cRIPGBM(chloride) suppresses the formation of RIPK2/TAK1 (prosurvival complex), and increases the formation of RIPK2/caspase 1 (proapoptotic complex). cRIPGBM(chloride) exerts potent anti-tumor activity in vivo in animal models.

体外研究

cRIPGBM(chloride) (0.25 μM；0-24 小时) 时间依赖性地激活半胱天冬酶 1、半胱天冬酶 9 和半胱天冬酶 7，以及 PARP 裂解。
cRIPGBM(chloride) (0.125 μM, 0.25 μM；24 小时) 在 CBM-1 GBM CSCs 中诱导 caspase 1 介导的细胞凋亡。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	GBM-1 GBM CSCs
Concentration:	50 nM, 100 nM, 125 nM, 250 nM, and 500 nM
Incubation Time:	3 h, 6 h, 12 h, and 24 h
Result:	Had the ability to regulate RIPK2 to act as a prosurvival or proapoptotic molecule. Significantly reduced RIPK2 binding to cIAP2 in a dose-dependent manner.

体内研究
(In Vivo)

cRIPGBM chloride (50 mg/kg；口服；每天两次，持续 5 周) 在携带患者来源的 GBM CSC 颅内异种移植的小鼠模型再，抑制肿瘤生长。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Orthotopic intracranial xenograft model in mouse
Dosage:	50 mg/kg
Administration:	PO; twice daily, 8 h apart, starting at day 7 postinjection; last for 5 weeks
Result:	Monitored by Fluorescence Tomography System. Decreased the tumor signal, as well as tumor size.

体内研究

cRIPGBM chloride (50 mg/kg；口服；每天两次，持续 5 周) 在携带患者来源的 GBM CSC 颅内异种移植的小鼠模型再，抑制肿瘤生长。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Orthotopic intracranial xenograft model in mouse
Dosage:	50 mg/kg
Administration:	PO; twice daily, 8 h apart, starting at day 7 postinjection; last for 5 weeks
Result:	Monitored by Fluorescence Tomography System. Decreased the tumor signal, as well as tumor size.

体内研究

cRIPGBM chloride (50 mg/kg；口服；每天两次，持续 5 周) 在携带患者来源的 GBM CSC 颅内异种移植的小鼠模型再，抑制肿瘤生长。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Orthotopic intracranial xenograft model in mouse
Dosage:	50 mg/kg
Administration:	PO; twice daily, 8 h apart, starting at day 7 postinjection; last for 5 weeks
Result:	Monitored by Fluorescence Tomography System. Decreased the tumor signal, as well as tumor size.

性状

Solid

溶解性数据

In Vitro:

DMSO : 25 mg/mL (55.94 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.2376 mL	11.1882 mL	22.3764 mL
5 mM	0.4475 mL	2.2376 mL	4.4753 mL
10 mM	0.2238 mL	1.1188 mL	2.2376 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献