3-Hydroxy Midostaurin CGP52421,97.02%
产品编号：Bellancom-108263| CAS NO：179237-49-1| 分子式：C35H30N4O5| 分子量：586.64
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3-Hydroxy Midostaurin CGP52421
| 产品介绍 | 3-Hydroxy Midostaurin (CGP 52421) 是 PKC412 的代谢产物，可有效抑制 FMS 样酪氨酸激酶 3 (FLT3) 自磷酸化，在培养基和血浆中的 IC50 分别为 132 nM 和 9.8 μM。与 PKC412 相比，3-Hydroxy Midostaurin 的选择性较低，但细胞毒性更高。 | ||||||||||||
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| 生物活性 | 3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412. | ||||||||||||
| 体外研究 |
CGP52421 (200, 400, 600, 800, 1000 nM) is more cytotoxic than PKC412 over the dose range 100 to 500 nM. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||||||
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| 性状 | Solid | ||||||||||||
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| 运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| 参考文献 |
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