HIF-2α-IN-8|cas:2734922-78-0|西域试剂

HIF-2α-IN-8

产品编号：Bellancom-148860| CAS NO：2734922-78-0| 分子式：C₁₇H₁₁ClF₇N₃O| 分子量：441.73

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货号	价格	库存与货期
Bellancom-148860	￥3000.00	杭州北京（现货）
Bellancom-148860	￥8800.00	杭州北京（现货）
Bellancom-148860	￥14000.00	杭州北京（现货）

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HIF-2α-IN-8

产品介绍

HIF-2α-IN-8 是一种有效的具有口服活性的 HIF2α 抑制剂，对 HIF2α SPA，HIF2α iScript，HIF2α HRE RGA 的 IC₅₀ 值分别为 9, 37, 246 nM。HIF-2α-IN-8 具有抗肿瘤活性。

生物活性

HIF-2α-IN-8 is a potent and orally active HIF2α inhibitor with IC₅₀ values of 9, 37, 246 nM for HIF2α SPA, HIF2α iScript, HIF2α HRE RGA, respectively. HIF-2α-IN-8 shows antitumor activity.

体外研究

体内研究

HIF-2α-IN-8 (Example 31) (30 mg/kg; p.o.; daily for 21 days) 在小鼠体内显示出抗肿瘤活性。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	6-9 weeks, female nude Crl:NU(NCr)-Foxn1nu-Homozygous mice (786-O mouse model)
Dosage:	30 mg/kg
Administration:	P.o.; started 34 days post tumor inoculation; daily for 21 days
Result:	Inhibited the tumor growth.

体内研究

HIF-2α-IN-8 (Example 31) (30 mg/kg; p.o.; daily for 21 days) 在小鼠体内显示出抗肿瘤活性。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	6-9 weeks, female nude Crl:NU(NCr)-Foxn1nu-Homozygous mice (786-O mouse model)
Dosage:	30 mg/kg
Administration:	P.o.; started 34 days post tumor inoculation; daily for 21 days
Result:	Inhibited the tumor growth.