TC-Mps1-12|cas:1206170-62-8|西域试剂

TC-Mps1-12,99.0%

产品编号：Bellancom-110115| CAS NO：1206170-62-8| 分子式：C₁₇H₂₀N₆O| 分子量：324.38

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货号	价格	库存与货期
Bellancom-110115	￥1750.00	杭州北京（现货）
Bellancom-110115	￥5200.00	杭州北京（现货）
Bellancom-110115	￥8800.00	杭州北京（现货）

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TC-Mps1-12

产品介绍

TC-Mps1-12 是一种高效、选择性的 Mps1 抑制剂，其 IC₅₀ 值为 6.4 nM。

生物活性

TC-Mps1-12 is a potent and selective monopolar spindle 1 (Mps1) inhibitor, with an IC₅₀ of 6.4 nM.

体外研究

TC-Mps1-12 inhibits the growth of pMps1 cell lines with IC50 values of 131 nM in autophosphorylation assay.
TC-Mps1-12 (72 hours) inhibits the growth of cells in a dose-dependent manner and with an IC₅₀ values of 0.84 μM.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	549 cells
Concentration:
Incubation Time:	72 hours
Result:	Inhibited the growth of cells in a dose-dependent manner and with an IC₅₀ values of 0.84 μM.

体内研究
(In Vivo)

TC-Mps1-12 (25-100 mg/kg; p.o.; daily; for 19 days) inhibits the growth of A549 cells in a dose-dependent manner in vivo. At a dose of 100 mg/kg, TC-Mps1-12 exhibits 47% tumor growth inhibition without body weight loss.
TC-Mps1-12 shows good PK properties with a Cmax of 3542 ng/mL and AUC of 6604 ng h/mL at an oral dose of 25 mg/kg.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	A549 mouse xenograft model
Dosage:	25 mg/kg, 50 mg/kg, 100 mg/kg
Administration:	Oral administration; once daily; for 19 days
Result:	Inhibited the growth of A549 cells in a dose-dependent manner.

Animal Model:	A549 mouse xenograft model (pharmacokinetic )
Dosage:	25 mg/kg
Administration:	Oral administration
Result:	C_max = 3542 ng/mL, AUC = 6604 ng h/mL

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	A549 mouse xenograft model
Dosage:	25 mg/kg, 50 mg/kg, 100 mg/kg
Administration:	Oral administration; once daily; for 19 days
Result:	Inhibited the growth of A549 cells in a dose-dependent manner.

Animal Model:	A549 mouse xenograft model (pharmacokinetic )
Dosage:	25 mg/kg
Administration:	Oral administration
Result:	C_max = 3542 ng/mL, AUC = 6604 ng h/mL

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	A549 mouse xenograft model
Dosage:	25 mg/kg, 50 mg/kg, 100 mg/kg
Administration:	Oral administration; once daily; for 19 days
Result:	Inhibited the growth of A549 cells in a dose-dependent manner.

Animal Model:	A549 mouse xenograft model (pharmacokinetic )
Dosage:	25 mg/kg
Administration:	Oral administration
Result:	C_max = 3542 ng/mL, AUC = 6604 ng h/mL