Iadademstat dihydrochloride ORY-1001 dihydrochloride; RG6016 dihydrochloride; RO 7051790 dihydrochloride|cas:1431303-72-8|西域试剂

Iadademstat dihydrochloride ORY-1001 dihydrochloride; RG6016 dihydrochloride; RO 7051790 dihydrochloride,99.83%

产品编号：Bellancom-12782T| CAS NO：1431303-72-8| 分子式：C₁₅H₂₄Cl₂N₂| 分子量：303.27

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-12782T	￥1540.00	杭州北京（现货）
Bellancom-12782T	￥2450.00	杭州北京（现货）
Bellancom-12782T	￥8450.00	杭州北京（现货）
Bellancom-12782T	￥15000.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

Iadademstat dihydrochloride ORY-1001 dihydrochloride; RG6016 dihydrochloride; RO 7051790 dihydrochloride

产品介绍

Iadademstat (ORY-1001) dihydrochloride 是一种不可逆的选择性赖氨酸特异性脱甲基酶 1A (KDM1A/LSD1) 抑制剂。

生物活性

Iadademstat (ORY-1001) dihydrochloride is a selective irreversible lysine (K)-specific demethylase 1A (KDM1A/LSD1) inhibitor.

体外研究

Iadademstat dihydrochloride is a KDM1A inhibitor that inactivate KDM1A by irreversible binding to the flavin adenine nucleotide (FAD) cofactor. Iadademstat has very high selectivity for KDM1A over the MAO enzymes, high selectivity over KDM1B and unrivaled subnanomolar cellular activity in differentiation and colony formation assays on mixed lineage leukemia (MLL)-translocated acute myeloid leukemia (AML) cell lines. Iadademstat provokes a time and dose-dependent induction of the Cd11b differentiation marker in MLL-AF9 cells, which interestingly preceeds changes in H3K4me2 levels. While MLL-translocated cells are especially sensitive, other acute leukemia (AL) cell lines also respond to Iadademstat.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Iadademstat reduces AML tumor growth in mice and rat xenografts and increases survival time in a disseminated model of T-ALL.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Iadademstat reduces AML tumor growth in mice and rat xenografts and increases survival time in a disseminated model of T-ALL.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

H₂O : 57.75 mg/mL (190.42 mM; Need ultrasonic and warming)

DMSO : 0.69 mg/mL (2.28 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.2974 mL	16.4870 mL	32.9739 mL
5 mM	0.6595 mL	3.2974 mL	6.5948 mL
10 mM	0.3297 mL	1.6487 mL	3.2974 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶