LMP744 MJ-III65; NSC706744|cas:308246-52-8|西域试剂

LMP744 MJ-III65; NSC706744,97.00%

产品编号：Bellancom-U00248| CAS NO：308246-52-8| 分子式：C₂₄H₂₄N₂O₇| 分子量：452.46

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货号	价格	库存与货期
Bellancom-U00248	￥1500.00	杭州北京（现货）
Bellancom-U00248	￥2900.00	杭州北京（现货）
Bellancom-U00248	￥4500.00	杭州北京（现货）

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LMP744 MJ-III65; NSC706744

产品介绍

LMP744 (MJ-III65) 是一种 DNA 嵌合剂，是 拓扑异构酶 1 (Top1) 抑制剂，具有抗肿瘤活性。

生物活性

LMP744 (MJ-III65) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity.

体外研究

The GI₅₀ value of LMP744 (MJ-III-65) for NCI60 cells is 0.1 μM.
LMP744 (0.1-5 μM, 3 days) induces dose-dependent accumulation of cells in the S and G₂ phases of the cell cycle.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	P388 and P388 Top1-deficient murine leukemia cells
Concentration:	0.1-100 μM
Incubation Time:	3 days
Result:	Induced dose-dependent accumulation of cells in the S and G₂ phases of the cell cycle.

体内研究
(In Vivo)

LMP744 (MJ-III65) (10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Athymic nude mice (nu/nu, female, 20-25 g, 8-12 weeks old) transplanted with A253 and FaDu human head and neck xenografts.
Dosage:	10, 25, or 50 mg/kg/week, 4 weeks
Administration:	I.V. push via tail vein
Result:	Moderately actived against human A253 and FaDu tumor xenografts without significant toxicity.

体内研究

LMP744 (MJ-III65) (10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Athymic nude mice (nu/nu, female, 20-25 g, 8-12 weeks old) transplanted with A253 and FaDu human head and neck xenografts.
Dosage:	10, 25, or 50 mg/kg/week, 4 weeks
Administration:	I.V. push via tail vein
Result:	Moderately actived against human A253 and FaDu tumor xenografts without significant toxicity.

体内研究

LMP744 (MJ-III65) (10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Athymic nude mice (nu/nu, female, 20-25 g, 8-12 weeks old) transplanted with A253 and FaDu human head and neck xenografts.
Dosage:	10, 25, or 50 mg/kg/week, 4 weeks
Administration:	I.V. push via tail vein
Result:	Moderately actived against human A253 and FaDu tumor xenografts without significant toxicity.

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 4.17 mg/mL (9.22 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.2101 mL	11.0507 mL	22.1014 mL
5 mM	0.4420 mL	2.2101 mL	4.4203 mL
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式