UNC0379 TFA|cas:1620401-83-3|西域试剂

UNC0379 TFA

产品编号：Bellancom-12335A| CAS NO：1620401-83-3| 分子式：C₂₅H₃₆F₃N₅O₄| 分子量：527.58

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-12335A		￥650.00	杭州北京（现货）
Bellancom-12335A		￥1000.00	杭州北京（现货）

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UNC0379 TFA

产品介绍

UNC0379 TFA 是一个选择性的底物竞争性的赖氨酸甲基转移酶 SETD8 (KMT5A) 抑制剂，IC₅₀ 值为 7.3 μM，K_D 值 of 18.3 μM。UNC0379 TFA 可用于炎症癌症的研究，如肺纤维化，卵巢癌，神经母细胞瘤。

生物活性

UNC0379 TFA is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 (KMT5A) with an IC₅₀ of 7.3 μM, K_D value of 18.3 μM. UNC0379 TFA can be used in the research of inflammation and cancers, such as pulmonary fibrosis, ovarian cancer, neuroblastoma.

体外研究

UNC0379 TFA (1-10 μM, 9 days) inhibits HGSOC cells proliferation.
UNC0379 TFA (10 μM, 96 h) increases in the proportion of sub-G1 phase cells in HGSOC cells.
UNC0379 TFA (10 μM, 48 h) induces myofibroblast de-differentiation and inhibits additional fibroblast to myofibroblast differentiation.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	JHOS2, JHOS3, JHOS4, OVCAR3, OVCAHO, OVKATE, KURAMOCHI, TYKnu
Concentration:	1-10 μM
Incubation Time:	9 days
Result:	Inhibited HGSOC cells proliferation with IC₅₀s ranging from 0.39 to 3.20 µM.

Cell Cycle Analysis

Cell Line:	JHOS3, OVCAR3
Concentration:	10 µM
Incubation Time:	96 h
Result:	Arrested cells in sub-G1 phase.

体内研究
(In Vivo)

UNC0379 TFA (intratracheal administration, 1 mg/kg/day, 1 mg/kg/day, on day7, 8, and 9) ameliorates the lung fibrosis in Bleomycin (BLM)-induced lung fibrosis mouse.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Bleomycin (BLM)-induced lung fibrosis mouse model
Dosage:	1 mg/kg/day
Administration:	Intratracheal administration, on day7, 8, and 9.
Result:	Ameliorated BLM-induced lung fibrosis (supported by the evaluation of the Ashcroft score and changes in the collagen content in the lung samples) without affecting pulmonary inflammation.

体内研究

UNC0379 TFA (intratracheal administration, 1 mg/kg/day, 1 mg/kg/day, on day7, 8, and 9) ameliorates the lung fibrosis in Bleomycin (BLM)-induced lung fibrosis mouse.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Bleomycin (BLM)-induced lung fibrosis mouse model
Dosage:	1 mg/kg/day
Administration:	Intratracheal administration, on day7, 8, and 9.
Result:	Ameliorated BLM-induced lung fibrosis (supported by the evaluation of the Ashcroft score and changes in the collagen content in the lung samples) without affecting pulmonary inflammation.

体内研究

UNC0379 TFA (intratracheal administration, 1 mg/kg/day, 1 mg/kg/day, on day7, 8, and 9) ameliorates the lung fibrosis in Bleomycin (BLM)-induced lung fibrosis mouse.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Bleomycin (BLM)-induced lung fibrosis mouse model
Dosage:	1 mg/kg/day
Administration:	Intratracheal administration, on day7, 8, and 9.
Result:	Ameliorated BLM-induced lung fibrosis (supported by the evaluation of the Ashcroft score and changes in the collagen content in the lung samples) without affecting pulmonary inflammation.

性状

Solid

溶解性数据

In Vitro:

H₂O : 100 mg/mL (189.54 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.8954 mL	9.4772 mL	18.9545 mL
5 mM	0.3791 mL	1.8954 mL	3.7909 mL
10 mM	0.1895 mL	0.9477 mL	1.8954 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献