GNE-502|cas:1953134-16-1|西域试剂

GNE-502,99.73%

产品编号：Bellancom-132294| CAS NO：1953134-16-1| 分子式：C₂₅H₃₀FN₃O₃S| 分子量：471.59

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-132294		￥8500.00	杭州北京（现货）
Bellancom-132294		￥14500.00	杭州北京（现货）

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GNE-502

产品介绍

GNE-502 是一种口服有效的雌激素受体 (ER) 降解剂。GNE-502 可用于乳腺癌研究。

生物活性

GNE-502 is an orally active and potent degrader for estrogen receptor (ER). GNE-502 can be used for the research of breast cancer.

体外研究

体内研究

GNE-502 (10 and 100 mg/kg; p.o.) possesses sufficient oral exposure to be tested in a WT MCF7 tumor xenograft model.
GNE-502 shows dose dependent tumor growth inhibition at 10 mg/kg and 30 mg/kg, with tumor stasis at 100 mg/kg.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mouse
Dosage:	10 and 100 mg/kg (Pharmacokinetic Analysis)
Administration:	p.o.; single dosage
Result:	Possessed sufficient oral exposure to be tested in a WT MCF7 tumor xenograft model.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mouse
Dosage:	10 and 100 mg/kg (Pharmacokinetic Analysis)
Administration:	p.o.; single dosage
Result:	Possessed sufficient oral exposure to be tested in a WT MCF7 tumor xenograft model.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (212.05 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.1205 mL	10.6024 mL	21.2049 mL
5 mM	0.4241 mL	2.1205 mL	4.2410 mL
10 mM	0.2120 mL	1.0602 mL	2.1205 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献