(S,R,S)-AHPC-C5-COOH VH032-C5-COOH,98.81%
产品编号:Bellancom-136055| CAS NO:2267282-19-7| 分子式:C29H42N4O5S| 分子量:558.73
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(S,R,S)-AHPC-C5-COOH VH032-C5-COOH
产品介绍 | (S,R,S)-AHPC-C5-COOH (VH032-C5-COOH) 是一种合成的 E3 连接酶配体-连接蛋白偶联物,包含 VH032 配体和 linker。VH032 是强效选择性的针对 VHL/ HIF-1α 相互作用的抑制剂,Kd 值为的 185 nM,有潜力用于贫血和缺血性疾病的相关研究。 | ||||||||||||
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生物活性 | (S,R,S)-AHPC-C5-COOH (VH032-C5-COOH) is a synthesized E3 ligase ligand-linker conjugate, contains the VH032 VHL-based ligand and a linker to form PROTACs. VH-032 is a selective and potent inhibitor of VHL/HIF-1α interaction with a Kd of 185 nM, has the potential for the study of anemia and ischemic diseases. | ||||||||||||
体外研究 |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.The von Hippel–Lindau tumor suppressor protein is the substrate-binding subunit of the VHL E3 ubiquitin ligase, it targets hydroxylated α subunit of HIFs for ubiquitination and subsequent proteasomal degradation. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||||||
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性状 | Solid | ||||||||||||
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运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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