(S,R,S)-AHPC-C5-COOH VH032-C5-COOH,98.81%

产品编号:Bellancom-136055| CAS NO:2267282-19-7| 分子式:C29H42N4O5S| 分子量:558.73

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货号 包装 价格 库存与货期 购买量 操作
Bellancom-136055
2500.00 杭州 北京(现货)
Bellancom-136055
4000.00 杭州 北京(现货)
Bellancom-136055
8500.00 杭州 北京(现货)
Bellancom-136055
13500.00 杭州 北京(现货)

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(S,R,S)-AHPC-C5-COOH VH032-C5-COOH

产品介绍 (S,R,S)-AHPC-C5-COOH (VH032-C5-COOH) 是一种合成的 E3 连接酶配体-连接蛋白偶联物,包含 VH032 配体和 linker。VH032 是强效选择性的针对 VHL/ HIF-1α 相互作用的抑制剂,Kd 值为的 185 nM,有潜力用于贫血和缺血性疾病的相关研究。
生物活性

(S,R,S)-AHPC-C5-COOH (VH032-C5-COOH) is a synthesized E3 ligase ligand-linker conjugate, contains the VH032 VHL-based ligand and a linker to form PROTACs. VH-032 is a selective and potent inhibitor of VHL/HIF-1α interaction with a Kd of 185 nM, has the potential for the study of anemia and ischemic diseases.

体外研究

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.The von Hippel–Lindau tumor suppressor protein is the substrate-binding subunit of the VHL E3 ubiquitin ligase, it targets hydroxylated α subunit of HIFs for ubiquitination and subsequent proteasomal degradation.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
体内研究
性状Solid
溶解性数据
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
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