Folinic acid 亚叶酸; leucovorin|cas:58-05-9|西域试剂

Folinic acid 亚叶酸; leucovorin,99.90%

产品编号：Bellancom-17556| CAS NO：58-05-9| 分子式：C₂₀H₂₃N₇O₇| 分子量：473.44

Folinic acid是肿瘤化疗药methotrexate等的佐剂。

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货号	价格	库存与货期
Bellancom-17556	￥600.00	杭州北京（现货）
Bellancom-17556	￥1000.00	杭州北京（现货）
Bellancom-17556	￥2500.00	杭州北京（现货）
Bellancom-17556	￥4000.00	杭州北京（现货）

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Folinic acid 亚叶酸; leucovorin

产品介绍

Folinic acid (Leucovorin) 是一种生物叶酸，通常与 Methotrexate (MTX) (HY-14519) 一起作为挽救剂服用，以降低 MTX 诱导的毒性。

生物活性

Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity.

体外研究

Methotrexate (MTX) alone induces a concentration-related increase in % micronucleated binucleated cells (MNBN) and % aberrant cells (Abs). There is a decrease in nuclear division index (NDI) with increase in MTX concentration. Similarly, the mitotic index (MI) also decreases in all concentrations of MTX tested. The addition of Folinic acid at 50 μg/ mL significantly reduces % MNBN (40-68%) and % Abs (36-77%). Inhibition is also seen at 5 μg/ mL Folinic acid (12 to 54% for MNBN and 20 to 61% for Abs) .

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Folinic acid (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following Methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	24 Balb/c young growing male mice aged 3 weeks (11.88 ± 0.25 g)
Dosage:	7.0 mg/kg
Administration:	Intraperitoneal injection; every second day; for 3 weeks
Result:	Following MTX administration appears to reverse this growth inhibition.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	24 Balb/c young growing male mice aged 3 weeks (11.88 ± 0.25 g)
Dosage:	7.0 mg/kg
Administration:	Intraperitoneal injection; every second day; for 3 weeks
Result:	Following MTX administration appears to reverse this growth inhibition.

性状

Solid

溶解性数据

In Vitro:

DMSO : 250 mg/mL (528.05 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.1122 mL	10.5610 mL	21.1220 mL
5 mM	0.4224 mL	2.1122 mL	4.2244 mL
10 mM	0.2112 mL	1.0561 mL	2.1122 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.08 mg/mL (4.39 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (4.39 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.08 mg/mL (4.39 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (4.39 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.08 mg/mL (4.39 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (4.39 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在西域网站选购。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

参考文献

. Keshava, C., et al., Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res, 1998. 397(2): p. 221-8. [Content Brief]

. Iqbal MP, et al. Effect of methotrexate and folinic acid on skeletal growth in mice. Acta Paediatr. 2003 Dec;92(12):1438-44. [Content Brief]

化学品安全说明书(MSDS)

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质检证书(COA)

产品编号(Item Number)

批号(Lot Number)

上游产品 1
6035-45-6
下游产品 1
59-30-3

Folinic acid 亚叶酸; leucovorin,99.90%

Folinic acid 亚叶酸; leucovorin

化学品安全说明书(MSDS)

质检证书(COA)

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