Haemanthamine|cas:466-75-1|西域试剂

Haemanthamine,96.64%

产品编号：Bellancom-114489A| CAS NO：466-75-1| 分子式：C₁₇H₁₉NO₄| 分子量：301.34

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-114489A		￥4100.00	杭州北京（现货）

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Haemanthamine

产品介绍

Haemanthamine 是从 Amaryllidaceae 植物中分离出来的一种蛇毒碱样生物碱，具有强大的抗癌活性。Haemanthamine 靶向核糖体以在翻译的延长阶段抑制蛋白质的生物合成。Haemanthamine 具有促凋亡，抗氧化剂，抗病毒，抗疟疾和抗惊厥活性。

生物活性

Haemanthamine is a crinine-type alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. Haemanthamine targets ribosomal that inhibits protein biosynthesis during the elongation stage of translation. Haemanthamine has pro-apoptotic, antioxidant, antiviral, antimalarial and anticonvulsant activities.

体外研究

Haemanthamine (1-100 µM; 24-48 hours; A2780 cells) treatment shows a time- and dose-dependent decrease in cell viability.
Haemanthamine (10 µM; 24-72 hours; A2780 cells) treatment leads to a significant inhibition of A2780 cell proliferation.
Haemanthamine binds at the A-site cleft of the peptidyl transferase center on the large ribosomal subunit, creating unique molecular interactions with the 25S rRNA. Haemanthamine has a highly specific inhibitory effect on pre-rRNA processing, leading to the activation of a p53-dependent antitumoral surveillance pathway known as nucleolar stress.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	A2780 ovarian cancer cells
Concentration:	1 µM, 10 µM, 50 µM, 100 µM
Incubation Time:	24 hours, 48 hours
Result:	Showed a time- and dose-dependent decrease in cell viability.

Cell Proliferation Assay

Cell Line:	A2780 ovarian cancer cells
Concentration:	10 µM
Incubation Time:	24 hours, 48 hours, 72 hours
Result:	Led to a significant inhibition of A2780 cell proliferation.

体内研究
(In Vivo)

A pharmacokinetic study of Haemanthamine in rats shows a rapid distribution phase of 30 min, a half-life of 70.4 min, and a major clearance through renal elimination. The high distribution volume of 13.7 L/kg suggests a high intracellular penetration, and its plasmatic concentration remains higher than 1 μM for at least 1 hr after a single 10-mg/kg administration.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (331.85 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.3185 mL	16.5926 mL	33.1851 mL
5 mM	0.6637 mL	3.3185 mL	6.6370 mL
10 mM	0.3319 mL	1.6593 mL	3.3185 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式