MKC8866|cas:1338934-59-0|西域试剂

MKC8866,99.52%

产品编号：Bellancom-104040| CAS NO：1338934-59-0| 分子式：C₁₈H₁₉NO₇| 分子量：361.35

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货号	价格	库存与货期
Bellancom-104040	￥2400.00	杭州北京（现货）
Bellancom-104040	￥3900.00	杭州北京（现货）
Bellancom-104040	￥7800.00	杭州北京（现货）
Bellancom-104040	￥12500.00	杭州北京（现货）

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MKC8866

产品介绍

MKC8866 是一种水杨醛类似物，有效的选择性 IRE1 RNase 抑制剂，在体外的 IC₅₀ 为 0.29 μM。 MKC8866 强烈抑制 Dithiothreitol 诱导的 XBP1s 表达，EC₅₀ 为 0.52 μM。MKC8866 抑制无应激 RPMI 8226 细胞，IC₅₀ 为 0.14 μM。 MKC8866 抑制乳腺癌细胞中的 IRE1 RNase 导致促肿瘤发生因子减少，同时也能抑制前列腺癌 (PCa) 肿瘤的生长。

生物活性

MKC8866, a salicylaldehyde analog, is a potent, selective IRE1 RNase inhibitor with an IC₅₀ of 0.29 μM in human vitro. MKC8866 strongly inhibits Dithiothreitol-induced X-box-binding protein 1-spliced (XBP1s) expression with an EC₅₀ of 0.52 μM and unstresses RPMI 8226 cells with an IC₅₀ of 0.14 μM. MKC8866 inhibits IRE1 RNase in breast cancer cells leading to the decreased production of pro-tumorigenic factors and it can inhibits prostate cancer (PCa) tumor growth.

体外研究

MKC8866 (20 μM; 6 days) decreases proliferation of all breast cancer cell lines.
MKC8866 (20 μM; 48 hours) reduces the number of cells entering S phase.
MKC8866 (0.2-10 μM; 3 days) suppresses the viability of all four cell lines in a dose-dependent manner under normal conditions, with the most robust effect in LNCaP cells.
MKC8866 (20 μM; 72 hours) is sufficient to completely block NSC 125973-induced expression of XBP1s .

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	MCF7, SKBR3, MDA-MB-231 and MCF10A cells
Concentration:	20 μM
Incubation Time:	For 6 days
Result:	Decreased proliferation of all breast cancer cell lines.

Cell Cycle Analysis

Cell Line:	MDA-MB-231, MCF7 and SKBR3 cells
Concentration:	20 μM
Incubation Time:	48 hours
Result:	Reduced the number of cells entering S phase.

Cell Cycle Analysis

Cell Line:	LNCaP, VCaP, 22Rv1 and C4-2B cells
Concentration:	0.2, 0.5, 1, 5, 10 μM
Incubation Time:	3 days
Result:	Suppressed the viability of all four cell lines in a dose-dependent manner.

Cell Cycle Analysis

Cell Line:	MDA-MB-231 cells
Concentration:	20 μM
Incubation Time:	72 hours
Result:	Completely blocked NSC 125973-induced expression of XBP1s.

体内研究
(In Vivo)

MKC8866 (oral ; 300 mg/kg; for 28 days) reduces tumor regrowth post-NSC 125973 withdrawal.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female athymic nude mice with MDA-MB-231 tumor
Dosage:	300 mg/kg
Administration:	Oral; for 28 days
Result:	Reduced tumor regrowth post-NSC 125973 withdrawal.

体内研究

MKC8866 (oral ; 300 mg/kg; for 28 days) reduces tumor regrowth post-NSC 125973 withdrawal.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female athymic nude mice with MDA-MB-231 tumor
Dosage:	300 mg/kg
Administration:	Oral; for 28 days
Result:	Reduced tumor regrowth post-NSC 125973 withdrawal.

体内研究

MKC8866 (oral ; 300 mg/kg; for 28 days) reduces tumor regrowth post-NSC 125973 withdrawal.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female athymic nude mice with MDA-MB-231 tumor
Dosage:	300 mg/kg
Administration:	Oral; for 28 days
Result:	Reduced tumor regrowth post-NSC 125973 withdrawal.

性状

Solid

溶解性数据

In Vitro:

DMSO : 6.67 mg/mL (18.46 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.7674 mL	13.8370 mL	27.6740 mL
5 mM	0.5535 mL	2.7674 mL	5.5348 mL
10 mM	0.2767 mL	1.3837 mL	2.7674 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式