WNK1-IN-1,99.40%
产品编号：Bellancom-151545| CAS NO：324022-39-1| 分子式：C13H15BrCl2N2O4S| 分子量：446.14
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WNK1-IN-1
| 产品介绍 | WNK1-IN-1 是 WNK1 的选择性抑制剂，IC50 值为 1.6 μM。WNK1-IN-1 抑制 OSR1 磷酸化，IC50 值为 4.3 μM。WNK1-IN-1 可用于血压调节和癌症的研究。 | ||||||||||||
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| 生物活性 | WNK1-IN-1 is a selective inhibitor of WNK1 with an IC50 value of 1.6 μM. WNK1-IN-1 inhibits OSR1 phosphorylation with an IC50 value of 4.3 μM. WNK1-IN-1 can be used for the research of blood pressure regulation and cancer. | ||||||||||||
| 体外研究 |
WNK1-IN-1 (0-1000 μM; 30 min) shows high potency to WNK1 with an IC50 value of 1.6 μM. WNK1-IN-1 (0.2-12.5 μM; 24 h) inhibits endogenous OSR1 phosphorylation with an IC50 value of 4.3 μM in MDAMB231 breast-cancer cells. WNK1-IN-1 (0-100 mM) is 10-fold more potent to WNK1 than WNK3 in Kinase-Glo assay. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||||||
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| 性状 | Solid | ||||||||||||
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| 运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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