FB23|cas:2243736-35-6|西域试剂

FB23,98.66%

产品编号：Bellancom-137187| CAS NO：2243736-35-6| 分子式：C₁₈H₁₄Cl₂N₂O₃| 分子量：377.22

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货号	价格	库存与货期
Bellancom-137187	￥1200.00	杭州北京（现货）
Bellancom-137187	￥2200.00	杭州北京（现货）
Bellancom-137187	￥4500.00	杭州北京（现货）
Bellancom-137187	￥7000.00	杭州北京（现货）

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FB23

产品介绍

FB23 是一种有效的，选择性的 FTO 去甲基化酶抑制剂，IC₅₀ 为 60 nM。FB23 直接与 FTO 结合并选择性抑制 FTO 的 mRNA N⁶-甲基腺嘌呤脱甲基酶活性。

生物活性

FB23 is a potent and selective FTO demethylase inhibitor with an IC₅₀ of 60 nM. FB23 directly binds to FTO and selectively inhibits FTO's mRNA N⁶-methyladenosine (m6A) demethylase activity.

体外研究

FB23 (72 hours) treatment inhibits acute myeloid leukemia (AML) cells proliferation with IC₅₀ values of 44.8 μM, 23.6 μM for NB4 and MONOMAC6 AML cells.
FB23 treatment causes the significant suppression of MYC targets, E2F targets, and G2M checkpoint signal cascades, which may contribute to the inhibitory effects of FTO inhibitors and FTO KD on cell cycle and proliferation. FB23 treatments activates apoptosis and p53 pathways.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

A single dose of 3 mg/kg FB23 is i.p. administrated to Sprague Dawley (SD) rats for the pharmacokinetic profile. The C_max and T_max value of FB23 are 142.5 ng/mL and 0.4 hr, respectively.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

A single dose of 3 mg/kg FB23 is i.p. administrated to Sprague Dawley (SD) rats for the pharmacokinetic profile. The C_max and T_max value of FB23 are 142.5 ng/mL and 0.4 hr, respectively.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 125 mg/mL (331.37 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.6510 mL	13.2549 mL	26.5097 mL
5 mM	0.5302 mL	2.6510 mL	5.3019 mL
10 mM	0.2651 mL	1.3255 mL	2.6510 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式