氨苯砜-D8同位素|Dapsone-d8|cas:557794-38-4|西域试剂

氨苯砜-D8同位素,Dapsone-d8,分析标准品,HPLC≥99%

产品编号：西域试剂-B0688S| CAS NO：557794-38-4| 分子式：C₁₂H₄D₈N₂O₂S| 分子量：256.35

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货号	价格	库存与货期
西域试剂-B0688S	￥1500.00	杭州北京（现货）
西域试剂-B0688S	￥4500.00	杭州北京（现货）
西域试剂-B0688S	￥8000.00	杭州北京（现货）

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氨苯砜-D8同位素

产品介绍

Dapsone-d₈ 是一种 Dapsone 的氘代物。Dapsone 是一种具有口服活性和血脑透性的磺酰类抗生素 (antibiotic)，具有抑菌、抗原虫、和抗炎活性。Dapsone 具有有效的抗麻风活性，抑制麻风杆菌细胞的叶酸合成 (folate synthesis)。Dapsone 可作为抗惊厥剂，也可用于皮肤病和胶质母细胞瘤的研究。

生物活性

Dapsone-d₈ is a deuterium labeled Dapsone. Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with antibacterial, antigenic and anti-inflammatory activities. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone can be used as an anticonvulsant and also in the research of skin and glioblastoma diseases[4][5].

体外研究

氨苯砜 (0.06 mM; 30 min) 抑制 N-Formyl-Met-Leu-Phe (HY-P0224) (1 μM) 和生理激动剂 C5a (100 nM) 触发的细胞内外超氧化物 (O₂^-) 和胰蛋白酶 E 的释放，而不是对 Phorbol 12-myristate 13-acetate (HY-18739) (100 nM) 没有作用^[5]。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

氨苯砜 (5 mg/kg; i.p.; 单次给药) 具有神经保护作用，显著改进了 Scopolamine (HY-N0296) 诱导记忆损伤小鼠的记忆获取能力^[6]。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Scopolamine-induced memory impairment model in mice^[6]
Dosage:	0.1, 0.3, 1, 5, and 10 mg/kg; 1 mg/kg for Scopolamine
Administration:	Intraperitoneal injection; single dose
Result:	Improved memory acquisition.

体内研究

氨苯砜 (5 mg/kg; i.p.; 单次给药) 具有神经保护作用，显著改进了 Scopolamine (HY-N0296) 诱导记忆损伤小鼠的记忆获取能力^[6]。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Scopolamine-induced memory impairment model in mice^[6]
Dosage:	0.1, 0.3, 1, 5, and 10 mg/kg; 1 mg/kg for Scopolamine
Administration:	Intraperitoneal injection; single dose
Result:	Improved memory acquisition.