LY5|cas:1436382-03-4|西域试剂

LY5

产品编号：Bellancom-12442| CAS NO：1436382-03-4| 分子式：C₁₅H₁₁N₃O₄S| 分子量：329.33

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货号	价格	库存与货期
Bellancom-12442	￥1900.00	杭州北京（现货）
Bellancom-12442	￥3200.00	杭州北京（现货）
Bellancom-12442	￥6800.00	杭州北京（现货）
Bellancom-12442	￥11500.00	杭州北京（现货）

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LY5

产品介绍

LY5 是 STAT3 的抑制剂，IC₅₀ 值为 0.5 μM。LY5 诱导细胞凋亡并抑制 STAT3 磷酸化。LY5 具有体内抗肿瘤活性，可用于癌症的研究。

生物活性

LY5 is a STAT3 inhibitor with an IC₅₀ value of 0.5 μM. LY5 induces apoptosis and inhibits STAT3 phosphorylation. LY5 shows antitumor activity in vivo, it can be used for the research of cancer.

体外研究

LY5 shows inhibition effects to U2OS, RH30 and RD2 cancer cells with IC₅₀ values of 0.52, 0.55 and 1.39 μM, respectively.
LY5 (0.25-1 μM; 16 h) induces apoptosis and inhibits STAT3 phosphorylation in human sarcoma cancer cells.
LY5 (0.25-1 μM; 5 h) inhibits STAT3 phosphorylation induced by IL-6.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	RH30 and EW8 cell lines
Concentration:	0.25-1 μM
Incubation Time:	16 hours
Result:	Completely inhibited Tyr705 phosphorylation at 0.5 μM and dose-dependently decreased in formation of P-STAT3.

体内研究
(In Vivo)

LY5 (5 mg/kg; i.p. once daily for 21 days) inhibits breast tumor growth in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Nude mice with MDA-MB-231 cancer cells injection
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection; 5 mg/kg; once daily; for 21 days
Result:	Suppressed tumor growth and significantly reduced the tumor sizes.

体内研究

LY5 (5 mg/kg; i.p. once daily for 21 days) inhibits breast tumor growth in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Nude mice with MDA-MB-231 cancer cells injection
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection; 5 mg/kg; once daily; for 21 days
Result:	Suppressed tumor growth and significantly reduced the tumor sizes.

体内研究

LY5 (5 mg/kg; i.p. once daily for 21 days) inhibits breast tumor growth in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Nude mice with MDA-MB-231 cancer cells injection
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection; 5 mg/kg; once daily; for 21 days
Result:	Suppressed tumor growth and significantly reduced the tumor sizes.