Thymidine 3',5'-diphosphate tetrasodium Deoxythymidine 3′,5′-diphosphate tetrasodium; pdTp tetrasodium|cas:118675-87-9|西域试剂

Thymidine 3',5'-diphosphate tetrasodium Deoxythymidine 3′,5′-diphosphate tetrasodium; pdTp tetrasodium,97.0%

产品编号：Bellancom-115581A| CAS NO：118675-87-9| 分子式：C₁₀H₁₂N₂Na₄O₁₁P₂| 分子量：490.12

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货号	价格	库存与货期
Bellancom-115581A	￥3500.00	杭州北京（现货）
Bellancom-115581A	￥9500.00	杭州北京（现货）
Bellancom-115581A	￥15000.00	杭州北京（现货）

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Thymidine 3',5'-diphosphate tetrasodium Deoxythymidine 3′,5′-diphosphate tetrasodium; pdTp tetrasodium

产品介绍

Thymidine 3',5'-diphosphate (Deoxythymidine 3′,5′-diphosphate) tetrasodium 是葡萄球菌核酸酶和含有 1 的都铎结构域 (SND1，MicroRNA 调控复合体 RISC 亚基) 与 [3,5-²H₂] 酪氨酸核酸酶 ( [3,5-²H₂] tyrosyl nuclease) 的选择性抑制剂。Thymidine 3',5'-diphosphate tetrasodium 具有抗肿瘤活性，在生化反应也可用作催化剂。

生物活性

Thymidine 3',5'-diphosphate (Deoxythymidine 3′,5′-diphosphate) tetrasodium is a selective inhibitor of staphylococcal nuclease and tudor domain containing 1 (SND1, the MicroRNA regulatory complex RISC subunit) and [3,5-²H₂] tyrosyl nuclease. Thymidine 3',5'-diphosphate tetrasodium has anti-tumor activity and can also be used as a catalyst in biochemical reactions.

体外研究

Thymidine 3',5'-diphosphate tetrasodium (200 µM；18 h) 通过抑制葡萄球菌核酸酶和含有 1 的都铎结构域 (SND1) 酶活性显著降低 WT 和 Alb/SND1 (特异性过表达 SND1 转基因小鼠) 肝细胞中 p65 表达水平和 p65 核易位。Thymidine 3',5'-diphosphate tetrasodium 抑制了 WT 和 Alb/SND1 肝细胞的球形形成。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Thymidine 3',5'-diphosphate tetrasodium (0.8 mg/kg；腹腔注射；每周 2 次持续 4 周) 在 WT B6/CBA 小鼠中对血清肝酶 (AST、ALT、AP)、总蛋白 (TP)、白蛋白 (Alb) 和球蛋白 (Glo) 无显著影响。
Thymidine 3',5'-diphosphate tetrasodium (0.8 mg/kg 和 1.6 mg/kg；静脉注射；每周 2 次持续 4 周) 显著抑制 WT B6/CBA 小鼠中肿瘤的生长。
Thymidine 3',5'-diphosphate tetrasodium (0.8, 0.16 和 0.32 mg/kg；皮下注射；每周 2 次持续 4 周) 抑制成年雄性 NSG 小鼠中肿瘤增殖、炎症反应和肿瘤起源细胞 (TIC) 标志物的表达。Thymidine 3',5'-diphosphate tetrasodium 上调了 PTEN、TGFBR2 和 CDKN1C 凋亡和选择性肿瘤抑制基因的表达。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	2 months old WT B6/CBA mice.
Dosage:	0.8 mg/kg.
Administration:	Intraperitoneal injection; twice a week for 4 weeks.
Result:	Had insignificant effect on serum liver enzymes, total protein, albumin and globulin and showed biosafety.

Animal Model:	NSG mice.
Dosage:	0.8, 0.16 or 0.32 mg/kg.
Administration:	Intravenous injection or subcutaneous injection; twice a week for 4 weeks.
Result:	Inhibited tumor growth, showed antitumor activity and immunomodulatory effects.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	2 months old WT B6/CBA mice.
Dosage:	0.8 mg/kg.
Administration:	Intraperitoneal injection; twice a week for 4 weeks.
Result:	Had insignificant effect on serum liver enzymes, total protein, albumin and globulin and showed biosafety.

Animal Model:	NSG mice.
Dosage:	0.8, 0.16 or 0.32 mg/kg.
Administration:	Intravenous injection or subcutaneous injection; twice a week for 4 weeks.
Result:	Inhibited tumor growth, showed antitumor activity and immunomodulatory effects.

性状

Solid

溶解性数据

In Vitro:

H₂O : 50 mg/mL (102.02 mM; Need ultrasonic)

DMSO : 3.33 mg/mL (6.79 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.0403 mL	10.2016 mL	20.4032 mL
5 mM	0.4081 mL	2.0403 mL	4.0806 mL
10 mM	0.2040 mL	1.0202 mL	2.0403 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献