Bapotulimab BAY-1905254

产品编号:Bellancom-P99460| CAS NO:2359413-58-2

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货号 包装 价格 库存与货期 购买量 操作
Bellancom-P99460
4600.00 杭州 北京(现货)
Bellancom-P99460
12000.00 杭州 北京(现货)

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Bapotulimab BAY-1905254

产品介绍 Bapotulimab (BAY-1905254) 是一种全人 IgG2 抗体,靶向含有免疫球蛋白样结构域的受体 2 (ILDR2)。Bapotulimab 具有抗肿瘤和免疫抑制作用。
生物活性

Bapotulimab (BAY-1905254) is a fully human IgG2 antibody targeting immunoglobulin-like domain containing receptor 2 (ILDR2). Bapotulimab has antitumor and immunosuppressive effects.

体外研究

Bapotulimab 阻断 ILDR2 对 T 细胞活化的免疫抑制作用。Bapotulimab 具有小鼠/人交叉反应性,因为 ILDR2 在人和鼠直系同源物的细胞外结构域之间具有 98% 的序列同一性
Bapotulimab (BAY-1905254;5、25、100 或 500 ng/mL) 在体外促进 T 细胞活化并增强抗原特异性 T 细胞增殖

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Bapotulimab(BAY-1905254;10 mg/kg;腹腔注射;在第 1 天和第 4 天)显示抗原特异性 T 细胞增殖和细胞毒性显着增加

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8- to 12-week-old CD45.1-expressing C57BL/6 wild-type mice injected with OT-I transgenic T cells
Dosage: 10 mg/kg
Administration: i.p.; on days 1 and 4
Result: Showed significantly increased antigen-specific T-cell proliferation and cytotoxicity.
体内研究

Bapotulimab(BAY-1905254;10 mg/kg;腹腔注射;在第 1 天和第 4 天)显示抗原特异性 T 细胞增殖和细胞毒性显着增加

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8- to 12-week-old CD45.1-expressing C57BL/6 wild-type mice injected with OT-I transgenic T cells
Dosage: 10 mg/kg
Administration: i.p.; on days 1 and 4
Result: Showed significantly increased antigen-specific T-cell proliferation and cytotoxicity.
性状
溶解性数据
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

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