2,6-二氯二苯胺, 99%,2,6-Dichlorodiphenylamine
产品编号:西域试剂-WR341058| CAS NO:15307-93-4| MDL NO:MFCD00269648| 分子式:C12H9Cl2N| 分子量:238.11
2,6-Dichlorodiphenylamine 是双氯芬酸钠 (HY-15037) 的结构类似物,具有抗白色念珠菌活性。Diclofenac Sodium 是一种有效的,非选择性抗炎剂,为 COX的抑制剂,在 CHO 细胞中,对人 COX-1 和 COX-2 的 IC50值分别为 4 和 1.3 nM。
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英文名称 | 2,6-Dichlorodiphenylamine | ||||||||||||||||
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CAS编号 | 15307-93-4 | ||||||||||||||||
产品描述 | 2,6-Dichlorodiphenylamine 是双氯芬酸钠 (HY-15037) 的结构类似物,具有抗白色念珠菌活性。Diclofenac Sodium 是一种有效的,非选择性抗炎剂,为 COX的抑制剂,在 CHO 细胞中,对人 COX-1 和 COX-2 的 IC50值分别为 4 和 1.3 nM。 | ||||||||||||||||
产品熔点 | 50-53 °C(lit.) | ||||||||||||||||
产品沸点 | 309.8±32.0 °C at 760 mmHg | ||||||||||||||||
产品密度 | 1.3±0.1 g/cm3 | ||||||||||||||||
产品闪点 | 141.2±25.1 °C | ||||||||||||||||
精确质量 | 237.011200 | ||||||||||||||||
PSA | 12.03000 | ||||||||||||||||
LogP | 4.77 | ||||||||||||||||
外观性状 | 灰白色至奶油色结晶固体 | ||||||||||||||||
蒸气压 | 0.0±0.7 mmHg at 25°C | ||||||||||||||||
折射率 | 1.650 | ||||||||||||||||
溶解性数据 | In Vitro:
DMSO : 100 mg/mL (419.97 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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稳定性 | 按规定使用不会分解,避氧化剂 | ||||||||||||||||
储存条件 | 密闭、阴凉、干燥处 |
相关文档
化学品安全说明书(MSDS)
下载MSDS质检证书(COA)
相关产品
符号 |
![]() ![]() GHS07, GHS09 |
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信号词 | Warning |
危害声明 | H315-H319-H410 |
警示性声明 | P273-P305 + P351 + P338-P501 |
个人防护装备 | dust mask type N95 (US);Eyeshields;Gloves |
危害码 (欧洲) | Xi: Irritant; |
风险声明 (欧洲) | R36/37/38 |
安全声明 (欧洲) | S26-S36 |
危险品运输编码 | UN 3077 9 / PGIII |
WGK德国 | 3 |
海关编码 | 2921440000 |
2,6-Dichlorodiphenylamine
Revision number: 5
SAFETY DATA SHEET Section1. IDENTIFICATION Product name:2,6-Dichlorodiphenylamine Revision number:5 Section2. HAZARDS IDENTIFICATION GHS classification PHYSICAL HAZARDSNot classified HEALTH HAZARDS Skin corrosion/irritationCategory 2 Category 2A Serious eye damage/eye irritation ENVIRONMENTAL HAZARDSNot classified GHS label elements, including precautionary statements Pictograms or hazard symbols Signal wordWarning Hazard statementsCauses skin irritation Causes serious eye irritation Precautionary statements: Wash hands thoroughly after handling. [Prevention] Wear protective gloves/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, [Response] if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention. IF ON SKIN: Gently wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. Section3. COMPOSITION/INFORMATION ON INGREDIENTS Substance/mixture:Substance Components:2,6-Dichlorodiphenylamine Percent:>98.0%(GC) CAS Number:15307-93-4 Synonyms:N-(2,6-Dichlorophenyl)aniline C12H9Cl2N Chemical Formula: Section4. FIRST AID MEASURES Inhalation:Remove victim to fresh air and keep at rest in a position comfortable for breathing. Get medical advice/attention if you feel unwell. 2,6-Dichlorodiphenylamine Section4. FIRST AID MEASURES Skin contact:Remove/Take off immediately all contaminated clothing. Gently wash with plenty of soap and water. If skin irritation or rash occurs: Get medical advice/attention. Eye contact:Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention. Ingestion:Get medical advice/attention if you feel unwell. Rinse mouth. A rescuer should wear personal protective equipment, such as rubber gloves and air- Protection of first-aiders: tight goggles. Section5. FIRE-FIGHTING MEASURES Suitable extinguishingDry chemical, foam, water spray, carbon dioxide. media: Specific hazards arising Take care as it may decompose upon combustion or in high temperatures to from the chemical:generate poisonous fume. Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place. In case of fire in the surroundings: Remove movable containers if safe to do so. Special protectiveWhen extinguishing fire, be sure to wear personal protective equipment. equipment for firefighters: Section6. ACCIDENTAL RELEASE MEASURES Personal precautions,Use personal protective equipment. Keep people away from and upwind of spill/leak. protective equipment and Entry to non-involved personnel should be controlled around the leakage area by emergency procedures: roping off, etc. Environmental precautions: Prevent product from entering drains. Methods and materials for Sweep dust to collect it into an airtight container, taking care not to disperse it. containment and cleaning Adhered or collected material should be promptly disposed of, in accordance with up: appropriate laws and regulations. Section7. HANDLING AND STORAGE Precautions for safe handling Technical measures:Handling is performed in a well ventilated place. Wear suitable protective equipment. Prevent dispersion of dust. Wash hands and face thoroughly after handling. Use a local exhaust if dust or aerosol will be generated. Advice on safe handling: Avoid contact with skin, eyes and clothing. Conditions for safe storage, including any incompatibilities Storage conditions:Keep container tightly closed. Store in a cool and dark place. Store away from incompatible materials such as oxidizing agents. Packaging material:Comply with laws. Section8. EXPOSURE CONTROLS / PERSONAL PROTECTION Engineering controls:Install a closed system or local exhaust as possible so that workers should not be exposed directly. Also install safety shower and eye bath. Personal protective equipment Respiratory protection: Dust respirator. Follow local and national regulations. Hand protection:Protective gloves. Safety glasses. A face-shield, if the situation requires. Eye protection: Skin and body protection: Protective clothing. Protective boots, if the situation requires. Section9. PHYSICAL AND CHEMICAL PROPERTIES Physical state (20°C):Solid Crystal- Powder Form: Colour:White - Greyish yellow green No data available Odour: 2,6-Dichlorodiphenylamine Section9. PHYSICAL AND CHEMICAL PROPERTIES pH: No data available Melting point/freezing point:51°C Boiling point/range:No data available Flash point:No data available Flammability or explosive limits: Lower:No data available Upper:No data available Relative density:No data available Solubility(ies): [Water]No data available [Other solvents] Soluble:Methanol Section10. STABILITY AND REACTIVITY Chemical stability:Stable under proper conditions. Possibility of hazardous No special reactivity has been reported. reactions: Incompatible materials: Oxidizing agents Hazardous decomposition Carbon monoxide, Carbon dioxide, Nitrogen oxides (NOx), Hydrogen chloride products: Section11. TOXICOLOGICAL INFORMATION Acute Toxicity:No data available Skin corrosion/irritation: No data available Serious eyeNo data available damage/irritation: Germ cell mutagenicity: No data available Carcinogenicity: IARC =No data available NTP =No data available Reproductive toxicity:No data available Section12. ECOLOGICAL INFORMATION Ecotoxicity: Fish:No data available Crustacea:No data available No data available Algae: Persistence / degradability: No data available No data available Bioaccumulative potential(BCF): Mobility in soil Log Pow:No data available Soil adsorption (Koc):No data available Henry's LawNo data available constant(PaM3/mol): Section13. DISPOSAL CONSIDERATIONS Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all federal, state and local regulations when disposing of the substance. Section14. TRANSPORT INFORMATION Hazards Class:Does not correspond to the classification standard of the United Nations UN-No:Not listed 2,6-Dichlorodiphenylamine Section15. REGULATORY INFORMATION Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002 and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport, loading and unloading were prescribed. SECTION 16 - ADDITIONAL INFORMATION N/A |
~83% ![]() 15307-93-4 |
文献:Osaka Yuki Kagaku Kogyo Kabushiki Kaisha Patent: US4908479 A1, 1990 ; |
~89% ![]() 15307-93-4 |
文献:Yung Shin Pharm. Ind. Co., Ltd. Patent: US5475139 A1, 1995 ; |
~94% ![]() 15307-93-4 |
文献:Buchwald, Stephen L.; Mauger, Christelle; Mignani, Gerard; Scholz, Ulrich Advanced Synthesis and Catalysis, 2006 , vol. 348, # 1-2 p. 23 - 39 |
~% ![]() 15307-93-4 |
文献:Pharmaceutical Chemistry Journal, , vol. 30, # 1 p. 38 - 40 |
~% ![]() 15307-93-4 |
文献:Pharmaceutical Chemistry Journal, , vol. 30, # 1 p. 38 - 40 |
~% ![]() 15307-93-4 |
文献:Advanced Synthesis and Catalysis, , vol. 348, # 1-2 p. 23 - 39 |