TP508|TP508 |cas:121341-81-9|西域试剂

TP508,TP508 ,99%

产品编号：西域试剂-WR354721| CAS NO：121341-81-9| 分子式：C₉₇H₁₄₆N₂₈O₃₆S| 分子量：2312.44

TP508 是一种 23 个氨基酸的非蛋白水解凝血酶肽，代表凝血酶分子受体结合结构域的一部分。TP508 可激活内皮 NO synthase (eNOS) 并刺激人内皮细胞中 NO 的产生。TP508 通过激活内皮细胞和干细胞以使血管再生和组织再生。

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货号	包装	价格	库存与货期	购买量	操作
西域试剂-WR354721		￥1200.00	杭州北京（现货）
西域试剂-WR354721		￥4300.00	杭州北京（现货）

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英文名称

TP508

CAS编号

121341-81-9

产品描述

溶解性数据

In Vitro:

H₂O

Peptide Solubility and Storage Guidelines:

1. Calculate the length of the peptide.

2. Calculate the overall charge of the entire peptide according to the following table:

	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3. Recommended solution:

Overall charge of peptide	Details
Negative (<0)	1. Try to dissolve the peptide in water first. 2. If water fails, add NH₄OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)	1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

体外研究

TP508 (50 μg/mL; 24 hours; HCAEC) treatment reverses radiation-induced endothelial dysfunction (ED) and loss of NO signaling by attenuating the downregulation of eNOS expression. TP508 treatment is able to stimulate NO production in the irradiated cells.
TP508 mitigates effects of nuclear radiation on human endothelial cells in culture restoring endothelial NO production, tube formation and accelerating repair of radiation-induced DNA double-strand breaks (DSB).
TP508 acts as an antagonist for the effects of thrombin. TP508 peptide inhibits these thrombin-induced effects through a RGD and αvβ3-related mechanism.

XIYU has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	Primary human coronary artery endothelial cells (HCAEC)
Concentration:	50 μg/mL
Incubation Time:	24 hours
Result:	Prevented the radiation-induced downregulation of eNOS.

体内研究

TP508 (10 mg/kg; intravenous injection; male CD-1 mice) treatment mitigates radiation-induced endothelial cell damage, also significantly increases survival of CD-1 mice when injected 24 h after 8.5 Gy exposure.

XIYU has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male CD-1 mice (12-15-week old) with γ irradiation
Dosage:	10 mg/kg
Administration:	Intravenous injection
Result:	Mitigated radiation-induced endothelial cell damage, also significantly increased survival of CD-1 mice.

储存条件

储存条件: 2-8°C

运输方式: 冰袋运输，根据产品的不同，可能会有相应调整。

化学品安全说明书(MSDS)

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TP508,TP508 ,99%

化学品安全说明书(MSDS)

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