Triamcinolone hexacetonide , ≥99%|Triamcinolone hexacetonide |cas:5611-51-8|西域试剂

Triamcinolone hexacetonide , ≥99%,Triamcinolone hexacetonide

产品编号：西域试剂-WR354749| CAS NO：5611-51-8| 分子式：C₃₀H₄₁FO₇| 分子量：532.64

Triamcinolone hexacetonide是一种常用的长效类固醇，用于治疗亚急性和慢性炎性关节疾病。

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货号	包装	价格	库存与货期	购买量	操作
西域试剂-WR354749		￥3742.00	杭州北京（现货）

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英文名称

Triamcinolone hexacetonide

CAS编号

5611-51-8

产品描述

Triamcinolone hexacetonide是一种常用的长效类固醇，用于治疗亚急性和慢性炎性关节疾病。

产品沸点

619.5ºC

产品密度

1.24 g/cm3

产品闪点

328.5ºC

精确质量

532.28400

PSA

99.13000

LogP

4.40590

折射率

1.556

溶解性数据

In Vitro:

DMSO : 41.67 mg/mL (78.23 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.8774 mL	9.3872 mL	18.7744 mL
5 mM	0.3755 mL	1.8774 mL	3.7549 mL
10 mM	0.1877 mL	0.9387 mL	1.8774 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.08 mg/mL (3.91 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (3.91 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在西域网站选购。

体内研究

曲安奈德（hexamcinolone hexacetonide）在化学诱导的关节软骨损伤模型中产生显着的，剂量依赖性的保护作用。注射曲安奈德（hexamcinolone hexauttonide）的豚鼠显示出不太明显的原纤维形成和骨赘。细胞损失不太广泛。单次注射曲安奈德（triamcinolone hexacetonide）进入兔的同侧膝关节，经过部分外侧半月板切除术和横断骨间质和侧支腓骨韧带可减少软骨细胞克隆，细胞损失，骨赘形成和纤维性颤动。商业上可获得的曲安奈德在玻璃体中的半衰期是曲安奈德己糖胺的两倍，但前者在该兔模型中对视网膜有毒。重新配制的异口服曲安奈德（triamcinolone hexacetonide）没有显示对视网膜功能或结构有害的证据。曲安奈德在舌神经损伤部位的局部应用导致可能有益的变化，例如降低的机械敏感性和增强的再生。

动物实验

豚鼠：给动物关节内注射0.1mL曲安奈德己酮，剂量为0.40mg / kg（组2和3）或0.04mg / kg（组4和5）。注射到第6组动物的膝盖中的CMC的体积与用于其他组中的关节内注射的CMC的体积相同，即0.1mL。当动物被杀死时，立即打开两个膝盖并进行严格检查。

储存条件

库房通风低温干燥

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

相关产品

危险品运输编码	NONH for all modes of transport

Section 1. Chemical Product and Company Identification
Triamcinolone Hexacetonide
Common Name/
Trade Name
Triamcinolone Hexacetonide

Section 4. First Aid Measures

Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at
least 15 minutes. Get medical attention if irritation occurs.
Skin ContactWash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.
Serious Skin ContactNot available.
InhalationIf inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get
medical attention.
Serious InhalationNot available.
IngestionDo NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an
unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight
clothing such as a collar, tie, belt or waistband.
Serious IngestionNot available.

Section 5. Fire and Explosion Data
Flammability of the Product May be combustible at high temperature.
Auto-Ignition Temperature Not available.
Flash PointsNot available.
Flammable LimitsNot available.
Products of CombustionThese products are carbon oxides (CO, CO2), halogenated compounds.
Fire Hazards in Presence of Slightly flammable to flammable in presence of heat.
Various SubstancesNon-flammable in presence of shocks.
Explosion Hazards in Presence Slightly explosive in presence of open flames and sparks.
Non-explosive in presence of shocks.
of Various Substances
SMALL FIRE: Use DRY chemical powder.
Fire Fighting Media
and InstructionsLARGE FIRE: Use water spray, fog or foam. Do not use water jet.
As with most organic solids, fire is possible at elevated temperatures
Special Remarks on
Fire Hazards
Special Remarks on Explosion Fine dust dispersed in air in sufficient concentrations, and in the presences of an ignition source is a potential dust
Hazardsexplosion hazard.

Section 6. Accidental Release Measures
Small SpillUse appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by
spreading water on the contaminated surface and dispose of according to local and regional authority
requirements.
Large SpillUse a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water
on the contaminated surface and allow to evacuate through the sanitary system.
Triamcinolone Hexacetonide

Section 7. Handling and Storage
PrecautionsKeep away from heat. Keep away from sources of ignition. Do not breathe dust.
StorageKeep container tightly closed. Keep container in a cool, well-ventilated area.

Section 8. Exposure Controls/Personal Protection
Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.
Personal ProtectionSafety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.
Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used
a Large Spillto avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist
BEFORE handling this product.
Exposure LimitsNot available.

Section 9. Physical and Chemical Properties
Physical state and appearance Solid. (Crystalline powder.)OdorOdorless.
TasteNot available.
Molecular Weight532.64 g/mole
White. Off-white.
Color
Not available.
pH (1% soln/water)
Boiling PointNot available.
Decomposition temperature: 295°C (563°F)
Melting Point
Critical TemperatureNot available.
Specific GravityNot available.
Vapor PressureNot applicable.
Vapor DensityNot available.
VolatilityNot available.
Odor ThresholdNot available.
Not available.
Water/Oil Dist. Coeff.
Ionicity (in Water)Not available.
Dispersion PropertiesNot available.
SolubilityInsoluble in cold water, hot water.

Section 10. Stability and Reactivity Data
StabilityThe product is stable.
Not available.
Instability Temperature
Conditions of InstabilityNot available.
Incompatibility with variousNot available.
substances
CorrosivityNot available.
Triamcinolone Hexacetonide
Not available.
Special Remarks on
Reactivity
Not available.
Special Remarks on
Corrosivity
PolymerizationWill not occur.

Section 11. Toxicological Information
Routes of EntryInhalation. Ingestion.
Toxicity to AnimalsLD50: Not available.
LC50: Not available.
Chronic Effects on Humans Not available.
Other Toxic Effects on
Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.
Humans
Special Remarks onNot available.
Toxicity to Animals
Special Remarks onMay cause adverse reproductive effects and birth defects (teratogenic) Human: passes through the placenta.
Chronic Effects on Humans
Special Remarks on otherPotential Health Effects:
Toxic Effects on HumansSkin: May cause skin irritation.
Eyes: May cause eye irritation.
Inhalation: May cause respiratory tract irritaition.
Ingestion: May cause gastrointestinal tract irritation with abdominal distension, nausea, vomiting. May cause
ulcerative esophagitis and peptic ulcers. May cause fluid and electrolyte disturbances resulting in sodium
retention, fluid retention, congestive heart failure in susceptible individuals, potassium loss, hypokalemic alkalosis,
increased calcium excretion, mild diuresis, polyuria, polydypsia, hypertension. May cause depression of
appetite/anorexia in contrast to voracious appetite ordinarily encountered with other glucocorticoids. Common
corticosteroids may cause euphoria whereas Triamcinolone may cause mood depression.
May cause steroid myopathy/muscular atrophy with loss of muscle mass and muscle weakness involving
muscles of the thighs, pelvis, and low back, muscle cramps. May cause other musculoskeletal effects such as
Osteoporosis, vertebral conpression fractures, pathologic fractures of long bones. May affect immune
system/immune response and increase the susceptibly to infections. May very rarely cause hypertension,
hyperglycemia, and may affect behavior/central nervous system (excitation, vertigo, headache, convulsions,
psychosis, hallucinations), and eye problems (glaucoma, mydriasis). Dermatologic effects may include impaired
wound healing, thin fragile skin, facial erythema, petechiae and ecchymoses.

Section 12. Ecological Information
Not available.
Ecotoxicity
BOD5 and CODNot available.
Products of BiodegradationPossibly hazardous short term degradation products are not likely. However, long term degradation products may
arise.
The products of degradation are more toxic than the product itself.
Toxicity of the Products
of Biodegradation
Special Remarks on theNot available.
Products of Biodegradation
Triamcinolone Hexacetonide

Section 13. Disposal Considerations
Waste DisposalWaste must be disposed of in accordance with federal, state and local environmental
control regulations.

Section 14. Transport Information
DOT ClassificationNot a DOT controlled material (United States).
Not applicable.
Identification
Not applicable.
Special Provisions for
Transport
DOT (Pictograms)

Section 15. Other Regulatory Information and Pictograms
No products were found.
Federal and State
Regulations
CaliforniaCalifornia prop. 65: This product contains the following ingredients for which the State of California has found
to cause cancer which would require a warning under the statute: No products were found.
Proposition 65
Warnings
California prop. 65: This product contains the following ingredients for which the State of California has found
to cause birth defects which would require a warning under the statute: No products were found.
Other RegulationsEINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.
Other ClassificationsWHMIS (Canada) Not controlled under WHMIS (Canada).
DSCL (EEC)This product is not classified according Not applicable.
to the EU regulations.
Health Hazard
HMIS (U.S.A.)1 National Fire Protection
1 Flammability
1 Association (U.S.A.)
Fire Hazard
1 0 Reactivity
Health
Reactivity
0
Specific hazard
Personal Protection
E
WHMIS (Canada)
(Pictograms)
DSCL (Europe)
(Pictograms)
TDG (Canada)
(Pictograms)
Triamcinolone Hexacetonide
ADR (Europe)
(Pictograms)
Protective Equipment
Gloves.
Lab coat.
Dust respirator. Be sure to use an
approved/certified respirator or
equivalent.

SECTION 16 - ADDITIONAL INFORMATION
N/A

[1]. Williams JM, et al. Triamcinolone hexacetonide protects against fibrillation and osteophyte formation following chemically induced articular cartilage damage. Arthritis Rheum. 1985 Nov;28(11):1267-74.

[2]. Abd-El-Barr MM, et al. Safety and pharmokinetics of triamcinolone hexacetonide in rabbit eyes. J Ocul Pharmacol Ther. 2008 Apr;24(2):197-205.

[3]. Yates JM, et al. The effect of triamcinolone hexacetonide on the spontaneous and mechanically-induced ectopic discharge following lingual nerve injury in the ferret. Pain. 2004 Oct;111(3):261-9.