丙酸倍氯米松, 99%,Beclomethasone Dipropionate

产品编号:西域试剂-WR383199| CAS NO:5534-09-8| MDL NO:MFCD00135613| 分子式:C28H37ClO7| 分子量:521.04

Beclometasone二丙酸盐是糖皮质素激动剂,为beclometasone游离形式的原药。

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用,

货号 包装 价格 库存与货期 购买量 操作
西域试剂-WR383199
522.00 杭州 北京(现货)
西域试剂-WR383199
1167.00 杭州 北京(现货)

增值税发票√顺丰快递√订货电话:18601927057

产品名称丙酸倍氯米松, 99%
英文名称Beclomethasone Dipropionate
CAS编号5534-09-8
产品描述Beclometasone二丙酸盐是糖皮质素激动剂,为beclometasone游离形式的原药。
产品熔点210ºC
产品沸点630.5±55.0 °C at 760 mmHg
产品密度1.3±0.1 g/cm3
产品闪点335.1±31.5 °C
精确质量520.222778
PSA106.97000
LogP4.59
外观性状白色结晶粉末
蒸气压0.0±4.2 mmHg at 25°C
折射率1.564
溶解性数据
In Vitro: 

DMSO : ≥ 100 mg/mL (191.92 mM)

H2O : < 0.1 mg/mL (ultrasonic) (insoluble)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9192 mL 9.5962 mL 19.1924 mL
5 mM 0.3838 mL 1.9192 mL 3.8385 mL
10 mM 0.1919 mL 0.9596 mL 1.9192 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.80 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.80 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液
  • 2.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.80 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.80 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在西域网站选购。
稳定性

常温常压下稳定,类白色或微黄色结晶性粉

储存条件

2-8℃ 避光,阴凉干燥处,密封保存 v

相关文档

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

相关产品


符号 GHS08
GHS08
信号词 Danger
危害声明 H360
警示性声明 P201-P308 + P313
个人防护装备 Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
危害码 (欧洲) T:Toxic
风险声明 (欧洲) R60;R61
安全声明 (欧洲) S53-S36/37/39-S45
危险品运输编码 NONH for all modes of transport
WGK德国 3
RTECS号 TU3805000
海关编码 2937290090

Section 1. Chemical Product and Company Identification
Beclomethasone Dipropionate
Common Name/
Trade Name
Beclomethasone Dipropionate

Section 3. Hazards Identification
Potential Acute Health Effects Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation.
Potential Chronic HealthCARCINOGENIC EFFECTS: Not available.
EffectsMUTAGENIC EFFECTS: Not available.
TERATOGENIC EFFECTS: Classified POSSIBLE for human.
DEVELOPMENTAL TOXICITY: Classified Development toxin [POSSIBLE].
Repeated exposure to a highly toxic material may produce general deterioration of health by an accumulation in
one or many human organs.

Section 4. First Aid Measures
Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at
least 15 minutes. Cold water may be used. WARM water MUST be used. Get medical attention if irritation
occurs.
Skin ContactWash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.
Serious Skin ContactNot available.
InhalationIf inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get
medical attention immediately.
Serious InhalationNot available.
IngestionDo NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an
unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if
symptoms appear.
Serious IngestionNot available.

Section 5. Fire and Explosion Data
Flammability of the Product May be combustible at high temperature.
Auto-Ignition Temperature Not available.
Flash PointsNot available.
Flammable LimitsNot available.
Products of CombustionThese products are carbon oxides (CO, CO2), halogenated compounds.
Fire Hazards in Presence of Slightly flammable to flammable in presence of heat.
Various Substances
Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available.
of Various SubstancesRisks of explosion of the product in presence of static discharge: Not available.
Fire Fighting MediaSMALL FIRE: Use DRY chemical powder.
and InstructionsLARGE FIRE: Use water spray, fog or foam. Do not use water jet.
Special Remarks onAs with most organic solids, fire is possible at elevated temperatures
Fire Hazards
Special Remarks on Explosion Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust
Hazardsexplosion hazard.
Beclomethasone Dipropionate

Section 6. Accidental Release Measures
Small SpillUse appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by
spreading water on the contaminated surface and dispose of according to local and regional authority
requirements.
Large SpillUse a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water
on the contaminated surface and allow to evacuate through the sanitary system.

Section 7. Handling and Storage
PrecautionsKeep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not
breathe dust.
StorageKeep container tightly closed. Keep container in a cool, well-ventilated area. It should be stored at 25 deg. C (77
deg. F), but storage at temperatures between 15 and 30 deg. C (59 to 86 deg. F) are acceptable. The product
should not be exposed to temperatures above 120 deg. F. because container may burst.

Section 8. Exposure Controls/Personal Protection
Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.
Personal ProtectionSafety glasses. Lab coat. Dust respirator. Use a dust respirator is ventilation if inadequate and handling of
product creates visible dust clouds. Be sure to use an approved/certified respirator or equivalent. Gloves.
Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used
a Large Spillto avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist
BEFORE handling this product.
Exposure LimitsNot available.

Section 9. Physical and Chemical Properties
Physical state and appearance Solid. (Solid powder.)OdorOdorless.
TasteNot available.
521.1 g/mole
Molecular Weight
ColorWhite to creamy
pH (1% soln/water)Not available.
Not available.
Boiling Point
Melting Point201°C (393.8°F) - 208 C.B^
Not available.
Critical Temperature
Specific GravityNot available.
Vapor PressureNot applicable.
Vapor DensityNot available.
VolatilityNot available.
Odor ThresholdNot available.
Water/Oil Dist. Coeff.Not available.
Not available.
Ionicity (in Water)
Dispersion PropertiesNot available.
Very slightly soluble in cold water.
Solubility
Beclomethasone Dipropionate

Section 10. Stability and Reactivity Data
The product is stable.
Stability
Instability TemperatureNot available.
Excess heat
Conditions of Instability
Not available.
Incompatibility with various
substances
CorrosivityNot available.
Special Remarks onNot available.
Reactivity
Special Remarks onNot available.
Corrosivity
PolymerizationWill not occur.

Section 11. Toxicological Information
Routes of EntryInhalation. Ingestion.
Toxicity to AnimalsWARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE.
Acute oral toxicity (LD50): >3750 mg/kg [Rat].
Acute toxicity of the dust (LC50): 51.6 mg/m3 2 hours [Rat].
Chronic Effects on Humans Not available.
Other Toxic Effects onSlightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.
Humans
Special Remarks on
Not available.
Toxicity to Animals
Special Remarks onNot available.
Chronic Effects on Humans
Special Remarks on otherAcute Potential Health Effects:
Toxic Effects on HumansSkin: May cause skin irritation.
Eyes: Dust may cause eye irritation.
Inhalation: A massive single dose is unlikely to cause adverse effects. Dust may cause respiratory tract
(nasopharyngeal) irritaiton with nasopharyngitis, nasal burning, rhinorrhea, hoarseness, bronchospasm, coughing
and possible nasal septum perforation. It may also cause headache, nausea, vomiting.
Ingestion: May cause gastrointestinal tract irritation with nausea, vomiting, hypermotility, diarrhea.
Other adverse effects of inhalation or ingestion may include: decreased or blurred vision, frequent urination,
increased thirst, increased appetite, indegestion, nervousness, convulsions, seizures, muscle contraction or
spasticity, trouble sleeping weight gain, dizziness, flushing of the face or cheeks, hiccups, and increased
sweating.
Chronic Potential Health Effects:
Inhalation or Ingestion: Prolonged or repeated inhalation or ingestion may cause possible hypersensitization; acne
or other skin problems; hip or shoulder pain; osteoporosis; gradual blurring or loss of vision (cataracts or
glaucoma); eye pain or redness; tearing and sensitivity of eyes to light; rounding out of the face; purple lines on
arms, face, legs, trunk, groin; unusual increase in hair growth; hypertension; menstrual irregularities; muscle
weakness; unusual bruising; rapid weight gain; swelling of feet or lower legs; irregular heartbeat; muscle cramps
or pain; unusual tiredness or weakness; impaired wound healing; headache; insomnia; pain in back, ribs, arms or
legs; continuing abdominal or stomach pain or burning; nausea; vomiting; bloody or black tarry stools; tendon
rupture; thin, fragile skin; blood (changes in erythrocyte and leukocyte count), thymus, and spleen
Medical Conditions Aggravated by Exposure: Hypersensitivity to material; ocular herpes simplex; AIDS or HIV
infection; heart disease; congestive heart failure; recent heart attack; intestinal anastomoses; strongyloides
infestation; diabetes mellitus; mayasthenia gravis; impaired kidney function or disease; esophagitis; gastritis or
peptic ulcer; chicken pox or measles (including recent exposure); tuberculosis; system fungal infections.
Beclomethasone Dipropionate

Section 12. Ecological Information
EcotoxicityNot available.
BOD5 and CODNot available.
Products of BiodegradationPossibly hazardous short term degradation products are not likely. However, long term degradation products may
arise.
The products of degradation are as toxic as the product itself.
Toxicity of the Products
of Biodegradation
Special Remarks on theNot available.
Products of Biodegradation

Section 13. Disposal Considerations
Waste DisposalWaste must be disposed of in accordance with federal, state and local environmental
control regulations.

Section 14. Transport Information
DOT ClassificationNot a DOT controlled material (United States).
Not applicable.
Identification
Not applicable.
Special Provisions for
Transport
DOT (Pictograms)

Section 15. Other Regulatory Information and Pictograms
No products were found.
Federal and State
Regulations
CaliforniaCalifornia prop. 65: This product contains the following ingredients for which the State of California has found
to cause cancer which would require a warning under the statute: No products were found.
Proposition 65
Warnings
California prop. 65: This product contains the following ingredients for which the State of California has found
to cause birth defects which would require a warning under the statute: Beclomethasone Dipropionate
Other RegulationsEINECS: This product is on the European Inventory of Existing Commercial Chemical Substances. EINECS no.
226-886-0.
WHMIS (Canada) Not controlled under WHMIS (Canada).
Other Classifications
DSCL (EEC)This product is not classified according Not applicable.
to the EU regulations.
Health Hazard
HMIS (U.S.A.)1 National Fire Protection
1 Flammability
1 Association (U.S.A.)
Fire Hazard
1 0 Reactivity
Health
Reactivity
0
Specific hazard
Personal Protection
E
Beclomethasone Dipropionate
WHMIS (Canada)
(Pictograms)
DSCL (Europe)
(Pictograms)
TDG (Canada)
(Pictograms)
ADR (Europe)
(Pictograms)
Protective Equipment
Gloves.
Lab coat.
Dust respirator. Be sure to use an
approved/certified respirator or
equivalent.
Beclomethasone Dipropionate
All chemicals may pose unknown hazards and should be used with caution. This Material Safety Data Sheet (MSDS) applies only to the material as packaged. If this product is
combined with other materials, deteriorates, or becomes contaminated, it may pose hazards not mentioned in this MSDS. It shall be the user's responsibility to develop proper
methods of handling and personal protection based on the actual conditions of use. While this MSDS is based on technical data judged to be reliable, Spectrum Quality Products,


SECTION 16 - ADDITIONAL INFORMATION
N/A

服务热线

13911702513
18601927057

微信客服