L-亮氨酸-7-氨基-4-甲基香豆素 盐酸盐, ≥99.9% (HPLC),L-Leucine-7-amido-4-methylcoumarin hydrochloride

产品编号:西域试剂-WR120792| CAS NO:62480-44-8| 分子式:C16H20N2O3 · HCl| 分子量:324.80

L-亮氨酸-7-氨基-4-甲基香豆素(Leu-AMC)盐酸盐是LAP3(亮氨酸氨基肽酶)的亮蓝色荧光肽基底物。L-亮氨酸-7-氨基-4-甲基香豆素盐酸盐可用于体外亮氨酸氨基肽酶抑制试验。

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货号 包装 价格 库存与货期 购买量 操作
西域试剂-WR120792
422.00 杭州 北京(现货)
西域试剂-WR120792
1466.00 杭州 北京(现货)
西域试剂-WR120792
4108.00 杭州 北京(现货)

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产品名称L-亮氨酸-7-氨基-4-甲基香豆素 盐酸盐, ≥99.9% (HPLC)
英文名称L-Leucine-7-amido-4-methylcoumarin hydrochloride
CAS编号62480-44-8
产品描述L-亮氨酸-7-氨基-4-甲基香豆素(Leu-AMC)盐酸盐是LAP3(亮氨酸氨基肽酶)的亮蓝色荧光肽基底物。L-亮氨酸-7-氨基-4-甲基香豆素盐酸盐可用于体外亮氨酸氨基肽酶抑制试验。
产品熔点248ºC
产品沸点503ºC at 760 mmHg
产品闪点258ºC
精确质量324.12400
PSA85.33000
LogP3.98860
外观性状白色至近乎于白色粉末
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (307.88 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.0788 mL 15.3941 mL 30.7882 mL
5 mM 0.6158 mL 3.0788 mL 6.1576 mL
10 mM 0.3079 mL 1.5394 mL 3.0788 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

体外研究

在KB 3.1细胞的亮氨酸氨基肽酶抑制试验中。观察到化合物3和5弱抑制金黄色葡萄球菌的生物膜形成,并抑制KB 3.1细胞中ʟ-Leu AMC水解的抑制活性。水解7-氨基-4-甲基香豆素(AMC)的量在荧光分光光度计中测定(激发/发射:365/440 nm)。

稳定性

指定条件下稳定,远离氧化物,强酸,强碱。

储存条件

存放在密封容器内,并放在阴凉,干燥处。

相关文档

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

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个人防护装备 Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
安全声明 (欧洲) S22-S24/25
危险品运输编码 NONH for all modes of transport
海关编码 2932209090
Name: L-Leucine-(4-Methyl-7-Coumarinylamide) Hydrochloride 99% Material Safety Data Sheet
Synonym: None known
CAS: 62480-44-8
Section 1 - Chemical Product MSDS Name:L-Leucine-(4-Methyl-7-Coumarinylamide) Hydrochloride 99% Material Safety Data Sheet
Synonym:None known

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
62480-44-8 L-Leucine-(4-Methyl-7-Coumarinylamide) 99 unlisted
Hazard Symbols: None Listed.
Risk Phrases: None Listed.

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Use with adequate ventilation.
Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 62480-44-8: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: almost white
Odor: none reported
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 248 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: > 248 deg C
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C16H20N2O3.HCl
Molecular Weight: 288.1516

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Incompatible materials, dust generation, excess heat.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 62480-44-8 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
L-Leucine-(4-Methyl-7-Coumarinylamide) Hydrochloride - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION


Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 28A After contact with skin, wash immediately with
plenty of water.
S 37 Wear suitable gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 62480-44-8: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 62480-44-8 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 62480-44-8 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A
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