四丁酸核黄素酯, ≥99%|Riboflavin Tetrabutyrate|cas:752-56-7|西域试剂

四丁酸核黄素酯, ≥99%,Riboflavin Tetrabutyrate

产品编号：西域试剂-WR129289| CAS NO：752-56-7| MDL NO：MFCD00059691| 分子式：C₃₃H₄₄N₄O₁₀| 分子量：656.73

Riboflavin tetrabutyrate是具有抗氧化和脂质过氧化物去除活性的亲脂性黄素衍生物。

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货号	价格	库存与货期
西域试剂-WR129289	￥86.00	杭州北京（现货）
西域试剂-WR129289	￥209.00	杭州北京（现货）
西域试剂-WR129289	￥663.00	杭州北京（现货）
西域试剂-WR129289	￥1794.00	杭州北京（现货）

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英文名称

Riboflavin Tetrabutyrate

CAS编号

752-56-7

产品描述

Riboflavin tetrabutyrate是具有抗氧化和脂质过氧化物去除活性的亲脂性黄素衍生物。

产品熔点

149ºC

产品密度

1.29g/cm3

精确质量

656.30600

PSA

185.84000

LogP

3.72880

折射率

1.584

溶解性数据

In Vitro:

DMSO : ≥ 100 mg/mL (152.27 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.5227 mL	7.6136 mL	15.2272 mL
5 mM	0.3045 mL	1.5227 mL	3.0454 mL
10 mM	0.1523 mL	0.7614 mL	1.5227 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

体外研究

核黄素四丁酸盐通过脂质过氧化抑制氧摄取。核黄素四丁酸酯抑制NADPH偶联和抗坏血酸诱导的微粒体脂质过氧化。在酶促氧化 - 还原反应过程中，在氢原子从多不饱和脂肪酸的活性亚甲基中被提取为自由基时，核黄素四丁酸酯似乎表现出其抗氧化作用。

体内研究

核黄素四丁酸酯可能通过抑制脂质过氧化作用改善患有动脉粥样硬化，糖尿病，脂肪肝等的患者的脂质代谢，从而导致血脂升高。饲喂核黄素四丁酸酯导致3-酮脂酰辅酶A硫解酶的肝活性增加50％的对照水平，而肾3-酮酰辅酶A硫解酶和肝和肾酰辅酶A合成酶和酰基 - 的活性增加。 CoA脱氢酶保持不受影响。肝脏3-酮脂酰辅酶A硫解酶活性的增加表明，长期使用核黄素四丁酸盐会导致肝脏中脂肪酸的β-氧化增加。

动物实验

大鼠：将核黄素四丁酸酯-14C（700μg，相当于400μg核黄素;总放射性2.19×105cpm）悬浮于0.2mL大豆油中并按口服给药。在注射的情况下，将相同量的核黄素四丁酸酯-14C溶解在1mL大豆油中并皮下注射到大鼠背部。

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

相关产品

安全声明 (欧洲)	S22-S24/25

Riboflavin Tetrabutyrate Revision number: 5
SAFETY DATA SHEET

Section1. IDENTIFICATION
Product name:Riboflavin Tetrabutyrate

Revision number:5

Section2. HAZARDS IDENTIFICATION
GHS classification
PHYSICAL HAZARDSNot classified
Not classified
HEALTH HAZARDS
ENVIRONMENTAL HAZARDSNot classified
GHS label elements, including precautionary statements
Pictograms or hazard symbolsNone
No signal word
Signal word
Hazard statementsNone
None
Precautionary statements:

Section3. COMPOSITION/INFORMATION ON INGREDIENTS
Substance/mixture:Substance
Components:Riboflavin Tetrabutyrate
Percent:>98.0%(LC)
CAS Number:752-56-7
Synonyms:Vitamin B2 Tetrabutyrate
Chemical Formula:C33H44N4O10

Section4. FIRST AID MEASURES
Inhalation:Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Get medical advice/attention if you feel unwell.
Skin contact:Remove/Take off immediately all contaminated clothing. Rinse skin with
water/shower. If skin irritation or rash occurs: Get medical advice/attention.
Eye contact:Rinse cautiously with water for several minutes. Remove contact lenses, if present
and easy to do. Continue rinsing. If eye irritation persists: Get medical
advice/attention.
Ingestion:Get medical advice/attention if you feel unwell. Rinse mouth.
Protection of first-aiders:A rescuer should wear personal protective equipment, such as rubber gloves and air-
tight goggles.

Section5. FIRE-FIGHTING MEASURES
Suitable extinguishingDry chemical, foam, water spray, carbon dioxide.
media:
Specific hazards arising Take care as it may decompose upon combustion or in high temperatures to
from the chemical:generate poisonous fume.
Riboflavin Tetrabutyrate

Section5. FIRE-FIGHTING MEASURES
Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing
method according to the surrounding situation is used. Uninvolved persons should
evacuate to a safe place. In case of fire in the surroundings: Remove movable
containers if safe to do so.
Special protectiveWhen extinguishing fire, be sure to wear personal protective equipment.
equipment for firefighters:

Section6. ACCIDENTAL RELEASE MEASURES
Use personal protective equipment. Keep people away from and upwind of spill/leak.
Personal precautions,
protective equipment and Entry to non-involved personnel should be controlled around the leakage area by
emergency procedures: roping off, etc.
Environmental precautions: Prevent product from entering drains.
Methods and materials for Sweep dust to collect it into an airtight container, taking care not to disperse it.
containment and cleaning Adhered or collected material should be promptly disposed of, in accordance with
up: appropriate laws and regulations.

Section7. HANDLING AND STORAGE
Precautions for safe handling
Handling is performed in a well ventilated place. Wear suitable protective equipment.
Technical measures:
Prevent dispersion of dust. Wash hands and face thoroughly after handling.
Use a local exhaust if dust or aerosol will be generated.
Advice on safe handling: Avoid contact with skin, eyes and clothing.
Conditions for safe storage, including any
incompatibilities
Storage conditions:Keep container tightly closed. Store in a cool and dark place.
Store away from incompatible materials such as oxidizing agents.
Packaging material:Comply with laws.

Section8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Install a closed system or local exhaust as possible so that workers should not be
Engineering controls:
exposed directly. Also install safety shower and eye bath.
Personal protective equipment
Respiratory protection: Dust respirator. Follow local and national regulations.
Hand protection:Protective gloves.
Eye protection:Safety glasses. A face-shield, if the situation requires.
Skin and body protection: Protective clothing. Protective boots, if the situation requires.

Section9. PHYSICAL AND CHEMICAL PROPERTIES
Physical state (20°C):Solid
Form:Crystal- Powder
Colour:Reddish yellow - Yellow red
Odour:No data available
pH: No data available
Melting point/freezing point:149°C
No data available
Boiling point/range:
Flash point:No data available
Flammability or explosive
limits:
No data available
Lower:
Upper:No data available
No data available
Relative density:
Solubility(ies):
Very slightly soluble
[Water]
[Other solvents]
Ethanol
Soluble:
Slightly soluble:Ether
Riboflavin Tetrabutyrate

Section10. STABILITY AND REACTIVITY
Chemical stability:Stable under proper conditions.
Possibility of hazardous No special reactivity has been reported.
reactions:
Incompatible materials: Oxidizing agents
Hazardous decomposition Carbon monoxide, Carbon dioxide, Nitrogen oxides (NOx)
products:

Section11. TOXICOLOGICAL INFORMATION
Acute Toxicity:ipr-rat LD50:>4500 mg/kg
orl-rat LD50:>7500 mg/kg
Skin corrosion/irritation: No data available
No data available
Serious eye
damage/irritation:
Germ cell mutagenicity: No data available
Carcinogenicity:
No data available
IARC =
NTP =No data available
No data available
Reproductive toxicity:
RTECS Number:VJ1755000

Section12. ECOLOGICAL INFORMATION
Ecotoxicity:
Fish:No data available
Crustacea:No data available
Algae:No data available
Persistence / degradability: No data available
BioaccumulativeNo data available
potential(BCF):
Mobility in soil
Log Pow:No data available
Soil adsorption (Koc):No data available
Henry's LawNo data available
constant(PaM3/mol):

Section13. DISPOSAL CONSIDERATIONS
Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material
with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system.
Observe all federal, state and local regulations when disposing of the substance.

Section14. TRANSPORT INFORMATION
Hazards Class:Does not correspond to the classification standard of the United Nations
UN-No:Not listed

Section15. REGULATORY INFORMATION
Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002
and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport,
loading and unloading were prescribed.
Riboflavin Tetrabutyrate

SECTION 16 - ADDITIONAL INFORMATION
N/A