氯霉素|Chloramphenicol|cas:56-75-7|西域试剂

氯霉素,Chloramphenicol,USP,99%,生物技术级

产品编号：西域试剂-WR142912| CAS NO：56-75-7| MDL NO：MFCD00078159| 分子式：C₁₁H₁₂Cl₂N₂O₅| 分子量：323.13

Chloramphenicol 是一种口服有效的广谱抗生素 (antibiotic)。Chloramphenicol 具有抗菌 (antibacterial) 活性。Chloramphenicol 抑制缺氧 A549 和 H1299 细胞中氧不稳定转录因子和缺氧诱导因子-1α (HIF-1α)。Chloramphenicol 可抑制血管内皮生长因子 (VEGF) 和葡萄糖转运蛋白 1 (glucose transporter 1) 的 mRNA 水平，最终降低 VEGF 的释放。Chloramphenicol 可用于厌氧菌感染和肺癌研究。

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
西域试剂-WR142912	￥74.00	杭州北京（现货）
西域试剂-WR142912	￥283.00	杭州北京（现货）
西域试剂-WR142912	￥868.00	杭州北京（现货）
西域试剂-WR142912	￥2468.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

英文名称

Chloramphenicol

CAS编号

56-75-7

产品描述

产品熔点

148-150 °C(lit.)

产品沸点

563.2±60.0 °C at 760 mmHg

产品密度

1.6±0.1 g/cm3

产品闪点

294.4±32.9 °C

精确质量

322.012329

PSA

115.38000

LogP

1.62

外观性状

白色至灰白色结晶粉末

蒸气压

0.0±1.6 mmHg at 25°C

折射率

1.623

溶解性

DMSO : ≥ 150 mg/mL (464.21 mM) Ethanol : 100 mg/mL (309.47 mM; Need ultrasonic) H2O : 3.06 mg/mL (9.47 mM; Need ultrasonic)

溶解性数据

In Vitro:

DMSO : ≥ 150 mg/mL (464.21 mM)

Ethanol : 100 mg/mL (309.47 mM; Need ultrasonic)

H₂O : 3.06 mg/mL (9.47 mM; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.0947 mL	15.4736 mL	30.9473 mL
5 mM	0.6189 mL	3.0947 mL	6.1895 mL
10 mM	0.3095 mL	1.5474 mL	3.0947 mL

请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (7.74 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (7.74 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (7.74 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (7.74 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (7.74 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (7.74 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。
4.

请依序添加每种溶剂： 10% EtOH 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (7.74 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (7.74 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 EtOH 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
5.

请依序添加每种溶剂： 10% EtOH 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (7.74 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (7.74 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 EtOH 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
6.

请依序添加每种溶剂： 10% EtOH 90% corn oil
Solubility: ≥ 2.5 mg/mL (7.74 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (7.74 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 EtOH 储备液加到 900 μL玉米油中，混合均匀。
7.

请依序添加每种溶剂： PBS
Solubility: 2.5 mg/mL (7.74 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在西域网站选购。

体外研究

Chloramphenicol (1-100 μg/mL, 18-24 h) inhibits the HIF-1α pathway in NSCLC cells in a concentration-dependent manner.
Chloramphenicol (100 μg/mL, 0-24 h) induces autophagy in NSCLC cells, substantially increases the levels of autophagic biomarkers (beclin-1, Atg12-Atg5 conjugates, and LC3-II).
Chloramphenicol induces abnormal differentiation and inhibits apoptosis in activated T cells.
Chloramphenicol can inhibit both bacterial and mitochondrial protein synthesis, causing mitochondrial stress and decreased ATP biosynthesis.
chloramphenicol (1-100 μg/mL) can induce matrix metalloproteinase (MMP)-13 expression and increase MMP-13 protein.
chloramphenicol (1-100 μg/mL) can activate c-Jun N-terminal kinases (JNK) and phosphatidylinositol 3-kinase (PI-3K)/Akt signaling, leading to c-Jun protein phosphorylation.
Chloramphenicol acts primarily on the 50S subunit of bacterial 70S rihosomes and inhibits peptide bond formation by suppressing peptidyl transferase activity.

XIYU has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	A549 and H1299 cells
Concentration:	0, 1, 10, 100 μg/mL
Incubation Time:	3 h and 24 h
Result:	In the 3-h-treated group, the viability of A549 and H1299 cells at 100 μg/mL concentration was 97.0 ± 3.9% and 98.1 ± 5.0%, respectively. The viability of A549 cells was 102.9 ± 1.3% and 99.2 ± 0.9%, whereas the viability of H1299 cells was 103.3 ± 1.9% and 93.8 ± 4.5%, under hypoxia and treatment with CoCl2, respectively.

Western Blot Analysis

Cell Line:	A549 and H1299 cells
Concentration:	0, 1, 10, 50, 100 μg/mL
Incubation Time:	18-24 h
Result:	Inhibited HIF-1α protein accumulation in NSCLC cells in a concentration-dependent manner, while the expression levels of ARNT remained unaltered. Had no effect on CoCl2 (250 μM, 3 h treatment)-mediated HIF-1α protein accumulation and SENP-1 protein reduction.

Western Blot Analysis

Cell Line:	A549 and H1299 cells
Concentration:	100 μg/mL
Incubation Time:	0, 6, 12, 24 h
Result:	Induced autophagy in NSCLC cells in a time-dependent manner. Upregulats the expression of beclin-1 and increased the levels of Atg12-Atg5 conjugates in both NSCLC cell lines, both in a time dependent and concentration-dependent manner. Augmented LC3-II and downregulated p62/STSQM1 in A549 cells. Induced an augmentation of p62/STSQM1, and a decrease in LC3-II levels in H1299 cells.

体内研究

Chloramphenicol (0-3500 mg/kg, Gavage, daily, for 5 days) decreases erythrocytes and erythrocyte precursors and reduces marrow erythroid cells were at day 1 post-dosing, and returns to normal by 14 days post-dosing.

XIYU has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female B6C3F1 mice (12-14 weeks old)
Dosage:	0, 2500 and 3500 mg/kg
Administration:	Gavage, daily, for 5 days
Result:	Cessation of erythropoiesis was evident at day 1 post-dosing. A recovery was seen at day 7 post-dosing at the 2500 mg/kg dose level and at between 7 and 14 days at the 3500 mg/kg dose level. Myelotoxicity was most pronounced in the erythroid series at each dose level. Depressed femoral marrow BFU-E and CFU-E at day 1 post-dosing. All the blood and marrow parameters in the present study returned to normal by 14 days post-dosing.

动物实验

*下述溶液配置方法仅为基于分子量计算出的理论值。不同产品在配置溶液前，需考虑其在不同溶剂中的溶解度限制。

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.0947 mL	15.4736 mL	30.9473 mL
5 mM	0.6189 mL	3.0947 mL	6.1895 mL
10 mM	0.3095 mL	1.5474 mL	3.0947 mL

不同实验动物依据体表面积的等效剂量转换表（参考来源于公开文献）

	小鼠	大鼠	兔	豚鼠	仓鼠	狗
重量 (kg)	0.02	0.15	1.8	0.4	0.08	10
体表面积 (m²)	0.007	0.025	0.15	0.05	0.02	0.5
K_m 系数	3	6	12	8	5	20

动物 A (mg/kg) = 动物 B (mg/kg) ×	动物 B的K_m系数
	动物 A的K_m系数

例如，依据体表面积折算法，将化合物用于小鼠的剂量20 mg/kg 换算成大鼠的剂量，需要将20 mg/kg 乘以小鼠的K_m系数（3），再除以大鼠的K_m系数（6），得到化合物用于大鼠的等效剂量为10 mg/kg。

储存条件

储存条件: 2-8°C

运输方式: 冰袋运输，根据产品的不同，可能会有相应调整。

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

符号	GHS08
信号词	Danger
危害声明	H350
警示性声明	P201-P280-P308 + P313
个人防护装备	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
危害码 (欧洲)	T:Toxic
风险声明 (欧洲)	R45
安全声明 (欧洲)	S53-S45
危险品运输编码	2811
WGK德国	3
RTECS号	AB6825000
海关编码	2941400000

1. 物质的识别

产品名：	Chloramphenicol
CAS号：	56-75-7
制造商/供应商：	西域试剂网站：www.hzbp.cn 邮件：13911702513@139.com

2. 合成/成分数据

产品名：	Chloramphenicol
别名：	Chloromycetin
分子式：	C11H12Cl2N2O5
分子量：	323.13

3. 急救措施

吸入后：	如果吸入，移至空气新鲜处，如果呼吸困难，给输氧，如呼吸停止，给予人工呼吸。
皮肤接触后：	用大量的水冲洗，移除污染的衣服和鞋子。
眼睛接触后：	检查并取下隐形眼镜，并用大量的水冲洗；呼叫医生。
吞食后：	如果吞食，用大量纯净水漱口；呼叫医生。

4. 消防措施

适当的灭火剂：	雾状水，二氧化碳，干粉或泡沫。
防护设备：	穿戴自给式呼吸器和防护服，以防止与皮肤和眼睛接触。

5. 泄漏应急处理

安全防范措施：	封锁泄漏区域；穿戴自给式呼吸器，防护服和厚橡胶手套。
清洁/收集措施：	使用液体粘合原料（硅藻土，通用粘合剂）吸取精细粉末；使用酒精擦洗表面和设备除去污渍；根据第11条处理被污染的材料。

6. 处理和储存

安全处理说明：	避免吸入和接触皮肤，眼睛及衣物；材料可能略微具有刺激性。
储存：	粉末型式 -20°C 3年；4°C 2年溶于溶剂 -80°C 6个月；-20°C 1个月

7. 接触控制和个人防护

呼吸设备：	NIOSH / MSHA认可的呼吸器。
双手保护：	耐化学腐蚀的橡胶手套。
眼睛防护：	化学安全护目镜。

8. 稳定性和反应活性

稳定性：	按照说明存储是稳定的；避免强氧化剂。
热分解/其他要避免的情况：	避免光和热。

9. 毒性资料

急性毒性：	无可用资料。
主要刺激性影响：	无可用资料。
在皮肤上：	无可用资料。
对眼睛：	无可用资料；可能具有刺激性。

10. 生态资料

一般注意事项：

无可用资料。

11. 废弃处置

按照所在国家，省份，县市和地方的法规处置。

12. 运输信息

正确的运输名称：	无
非危险品运输：	这种物质被视为非危险品运输。

13. 法规信息

尚未有针对此产品作出的化学安全性评估。

14. 其他信息

上游产品 9
10318-17-9 382142-89-4 116-54-1 119-62-0
555-16-8 294637-52-8 7411-64-5 66607-69-0
123410-34-4
下游产品 9
530-43-8 17709-53-4 3544-94-3 555-16-8
56-75-7 134-90-7 119-62-0 17364-04-4
16255-48-4

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