1-[1-[6-([1,1'-联苯]-4-基羰基)-5,6,7,8-四氢吡啶并[4,3-d]嘧啶-4-基]-4-哌啶基]-1-丁酮, ≥99% (HPLC),PK-THPP
产品编号:西域试剂-WR144118| CAS NO:1332454-07-5| MDL NO:MFCD28396418| 分子式:C29H32N4O2| 分子量:468.59
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用途: | PK-THPP is a potent antagonist of tandem pore potassium channel subunit TASK-3 (KCNK9, K2P9.1) with an IC50 value of 35 nM for TASK-3 compared to 303 nM for TASK-1 and with >140 fold selectivity over a wider range of potassium channels. PK-THPP was found to act as a respiratory stimulant, stimulating breathing in isoflurane-anesthetized rats. |
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储存条件: | 2-8°C |
颜色: | 粉末 |
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