3-磷酸​​-D-甘油酸钡盐二水合物 ,glyceric acid 3-(barium phosphate)

产品编号:Bellancom-B413054| CAS NO:22457-55-2| 分子式:C3H5BaO7P| 分子量:321.3684

3-Phosphoglyceric acid barium 是一种糖酵解和卡尔文循环中的代谢中间体。3-Phosphoglyceric acid barium 可参与肺泡巨噬细胞的表观遗传调控。

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Bellancom-B413054
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产品名称 3-磷酸​​-D-甘油酸钡盐二水合物
英文名称glyceric acid 3-(barium phosphate)
CAS编号22457-55-2
产品描述3-Phosphoglyceric acid barium 是一种糖酵解和卡尔文循环中的代谢中间体。3-Phosphoglyceric acid barium 可参与肺泡巨噬细胞的表观遗传调控。
产品沸点536.6ºC at 760mmHg
产品闪点278.3ºC
精确质量321.882538
PSA246.20000
蒸气压9.37E-14mmHg at 25°C
体外研究

3-磷酸甘油酸(400μM;24小时;BMDMs)治疗增强了VHL缺陷巨噬细胞中Spp1的转录,减少的H3K4me3修饰也被逆转。3-磷酸甘油处理显著增加IL-4刺激巨噬细胞中Spp1的基因表达和H3K4me3沉积。在酵母中,3-磷酸甘油酸作为多组分酶复合物(包括丝氨酸代谢酶和丙酮酸激酶亚型2(PKM2)同源物)形成的代谢检查点,该复合物感知丝氨酸代谢和糖酵解,并调节H3K4甲基化和组蛋白磷酸化。RT-PCR细胞系:骨髓源性巨噬细胞(BMDMs)浓度:400μM孵育时间:24小时结果:VHL缺陷巨噬细胞Spp1转录增强,H3K4me3修饰减少。

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3-Phospho-D-glyceric Acid Barium Salt Dihydrate Revision number: 6
SAFETY DATA SHEET

Section1. IDENTIFICATION
Product name:3-Phospho-D-glyceric Acid Barium Salt Dihydrate

Revision number:6

Section2. HAZARDS IDENTIFICATION
GHS classification
PHYSICAL HAZARDSNot classified
HEALTH HAZARDS
Acute toxicity (Oral)Category 3
Category 3
Acute toxicity (Inhalation)
ENVIRONMENTAL HAZARDSNot classified
GHS label elements, including precautionary statements
Pictograms or hazard symbols
Signal wordDanger
Hazard statementsToxic if swallowed or if inhaled
Precautionary statements:
[Prevention]Avoid breathing dust/fume/gas/mist/vapours/spray.
Use only outdoors or in a well-ventilated area.
Do not eat, drink or smoke when using this product.
Wash hands thoroughly after handling.
[Response]IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for
breathing. Call a POISON CENTER or doctor/physician.
IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. Rinse
mouth.
[Storage]Store in a well-ventilated place. Keep container tightly closed.
Store locked up.
[Disposal]Dispose of contents/container through a waste management company authorized by
the local government.

Section3. COMPOSITION/INFORMATION ON INGREDIENTS
Substance/mixture:Substance
Components:3-Phospho-D-glyceric Acid Barium Salt Dihydrate
Percent:>98.0%(T)
CAS Number:22457-55-2
Barium 3-Phospho-D-glycerate Dihydrate
Synonyms:
Chemical Formula:C3H5BaO7P·2H2O
3-Phospho-D-glyceric Acid Barium Salt
Dihydrate

Section4. FIRST AID MEASURES
Inhalation:Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Call a POISON CENTER or doctor/physician.
Skin contact:Remove/Take off immediately all contaminated clothing. Rinse skin with
water/shower. If skin irritation or rash occurs: Get medical advice/attention.
Eye contact:Rinse cautiously with water for several minutes. Remove contact lenses, if present
and easy to do. Continue rinsing. If eye irritation persists: Get medical
advice/attention.
Ingestion:Immediately call a POISON CENTER or doctor/physician. Rinse mouth.
A rescuer should wear personal protective equipment, such as rubber gloves and air-
Protection of first-aiders:
tight goggles.

Section5. FIRE-FIGHTING MEASURES
Suitable extinguishingDry chemical, foam, water spray, carbon dioxide.
media:
Specific hazards arising Take care as it may decompose upon combustion or in high temperatures to
from the chemical:generate poisonous fume.
Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing
method according to the surrounding situation is used. Uninvolved persons should
evacuate to a safe place. In case of fire in the surroundings: Remove movable
containers if safe to do so.
Special protectiveWhen extinguishing fire, be sure to wear personal protective equipment.
equipment for firefighters:

Section6. ACCIDENTAL RELEASE MEASURES
Personal precautions,Use extra personal protective equipment (P3 filter respirator for toxic particles). Keep
protective equipment and people away from and upwind of spill/leak. Entry to non-involved personnel should
emergency procedures: be controlled around the leakage area by roping off, etc.
Environmental precautions: Prevent product from entering drains.
Methods and materials for Sweep dust to collect it into an airtight container, taking care not to disperse it.
containment and cleaning Adhered or collected material should be promptly disposed of, in accordance with
up: appropriate laws and regulations.

Section7. HANDLING AND STORAGE
Precautions for safe handling
Technical measures:Handling is performed in a well ventilated place. Wear suitable protective equipment.
Prevent dispersion of dust. Wash hands and face thoroughly after handling.
Use a closed system if possible. Use a local exhaust if dust or aerosol will be
generated.
Advice on safe handling: Avoid contact with skin, eyes and clothing.
Conditions for safe storage, including any
incompatibilities
Storage conditions:Keep container tightly closed. Store in a cool, dark and well-ventilated place.
Store locked up.
Store away from incompatible materials such as oxidizing agents.
Comply with laws.
Packaging material:

Section8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering controls:Install a closed system or local exhaust. Also install safety shower and eye bath.
Personal protective equipment
Respiratory protection: Dust respirator, self-contained breathing apparatus(SCBA), supplied air respirator,
etc. Use respirators approved under appropriate government standards and follow
local and national regulations.
Impervious gloves.
Hand protection:
Eye protection:Safety goggles. A face-shield, if the situation requires.
Skin and body protection: Impervious protective clothing. Protective boots, if the situation requires.
3-Phospho-D-glyceric Acid Barium Salt
Dihydrate

Section9. PHYSICAL AND CHEMICAL PROPERTIES
Physical state (20°C):Solid
Crystal- Powder
Form:
Colour:White - Almost white
No data available
Odour:
pH: No data available
Melting point/freezing point:No data available
Boiling point/range:No data available
No data available
Flash point:
Flammability or explosive
limits:
Lower:No data available
Upper:No data available
Relative density:No data available
Solubility(ies):
[Water]No data available
[Other solvents]
Soluble:Hydrochloric acid

Section10. STABILITY AND REACTIVITY
Chemical stability:Stable under proper conditions.
Possibility of hazardous No special reactivity has been reported.
reactions:
Incompatible materials: Oxidizing agents
Hazardous decomposition Carbon monoxide, Carbon dioxide, Phosphorus oxides
products:

Section11. TOXICOLOGICAL INFORMATION
Acute Toxicity:No data available
Skin corrosion/irritation: No data available
Serious eyeNo data available
damage/irritation:
Germ cell mutagenicity: No data available
Carcinogenicity:
IARC =No data available
No data available
NTP =
Reproductive toxicity:No data available

Section12. ECOLOGICAL INFORMATION
Ecotoxicity:
Fish:No data available
Crustacea:No data available
Algae:No data available
Persistence / degradability: No data available
BioaccumulativeNo data available
potential(BCF):
Mobility in soil
Log Pow:No data available
Soil adsorption (Koc):No data available
Henry's LawNo data available
constant(PaM3/mol):

Section13. DISPOSAL CONSIDERATIONS
Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material
with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system.
Observe all federal, state and local regulations when disposing of the substance.
3-Phospho-D-glyceric Acid Barium Salt
Dihydrate

Section14. TRANSPORT INFORMATION
Hazards Class:6.1: Toxic substance.
UN-No:1564
Proper shipping name:Barium compound, n.o.s.
Packing group:III

Section15. REGULATORY INFORMATION
Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002
and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport,
loading and unloading were prescribed.


SECTION 16 - ADDITIONAL INFORMATION
N/A

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