3,3',5-三碘-L-甲状腺素钠 ,3,3',5-Triiodo-L-thyronine, sodium salt ,≥98%

产品编号:Bellancom-B414367| CAS NO:55-06-1| 分子式:C15H11I3NNaO4| 分子量:690.9706

3,3',5-Triiodo-L-thyronine sodium 是一种有效的甲状腺激素 (thyroid hormone),可以结合并激活 β1甲状腺激素受体 (TRβ1)。

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货号 包装 价格 库存与货期 购买量 操作
Bellancom-B414367
60.00 杭州 北京(现货)
Bellancom-B414367
251.00 杭州 北京(现货)
Bellancom-B414367
417.00 杭州 北京(现货)
Bellancom-B414367
1955.00 杭州 北京(现货)
Bellancom-B414367
6958.00 杭州 北京(现货)

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产品名称 3,3',5-三碘-L-甲状腺素钠
英文名称3,3',5-Triiodo-L-thyronine, sodium salt
CAS编号55-06-1
产品描述3,3',5-Triiodo-L-thyronine sodium 是一种有效的甲状腺激素 (thyroid hormone),可以结合并激活 β1甲状腺激素受体 (TRβ1)。
产品熔点205 °C (dec.)(lit.)
产品沸点563.5ºC at 760 mmHg
产品闪点294.6ºC
精确质量672.771973
PSA95.61000
LogP3.31830
外观性状白色至米色粉末
溶解性数据
In Vitro: 

0.1 M NaOH : 12.5 mg/mL (18.57 mM; ultrasonic and adjust pH to 11 with NaOH)

DMSO : 5.56 mg/mL (8.26 mM; ultrasonic and warming and heat to 60°C)

H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.4860 mL 7.4299 mL 14.8597 mL
5 mM 0.2972 mL 1.4860 mL 2.9719 mL
10 mM 0.1486 mL 0.7430 mL 1.4860 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.71 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (3.71 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液
  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.71 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (3.71 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.71 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (3.71 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在西域网站选购。
靶点

TRβ1

体外研究

3,3',5-三碘-L-甲状腺素(T3,100nM)刺激TRβ1过表达的肝细胞增殖。 3,3',5-三碘-L-甲状腺素与人β1甲状腺激素受体(hTRβ1)结合,并改变其构象。 3,3',5-三碘-L-甲状腺素促进生长,诱导分化并调节代谢作用。

细胞实验

制备甲状腺激素耗尽(Td)血清。进行甲基纤维素中肝癌细胞的生长。为了确定3,3',5-三碘-L-甲状腺素(T3)对细胞生长的影响,在第0天将细胞以3×104个细胞/ 60mm培养皿的密度接种,并在含有培养基的培养基中培养。 5%常规血清,5%Td或5%Td和100nM T3。初始接种后3周,甲基纤维素中的集落形成评分。

储存条件

本品应密封于0℃以下干燥避光保存。

相关文档

化学品安全说明书(MSDS)

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危害码 (欧洲) Xn: Harmful;
风险声明 (欧洲) R20/21/22
安全声明 (欧洲) S22-S24/25
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Name: 3 3 5- Triiodo-L-Thyronine Sodium Salt 95% Material Safety Data Sheet
Synonym: Liothyronine Sodium
CAS: 55-06-1
Section 1 - Chemical Product MSDS Name:3 3 5- Triiodo-L-Thyronine Sodium Salt 95% Material Safety Data Sheet
Synonym:Liothyronine Sodium

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
55-06-1 3,3',5- Triiodo-L-Thyronine, Sodium Sa 95% 200-223-5
Hazard Symbols: None Listed.
Risk Phrases: None Listed.

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Hygroscopic (absorbs moisture from the air).The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Runoff from fire control or dilution water may cause pollution.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use agent most appropriate to extinguish fire.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Hormones and antibiotics room. Store protected from moisture.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 55-06-1: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Powder
Color: beige
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 205 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C15H11I3NO4Na
Molecular Weight: 672.96

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, dust generation, excess heat, strong oxidants, exposure to moist air or water.
Incompatibilities with Other Materials:
Moisture, oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen, hydrogen iodide.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 55-06-1: YP2836500 LD50/LC50:
Not available.
Carcinogenicity:
3,3',5- Triiodo-L-Thyronine, Sodium Salt - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION


Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
S 28A After contact with skin, wash immediately with
plenty of water.
S 37 Wear suitable gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 55-06-1: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 55-06-1 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 55-06-1 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

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