2-氨基-1-苯甲基苯并咪唑 ,2-amino-1-(phenylmethyl)-1H-benzimidazole ,试剂级

产品编号:Bellancom-B293031| CAS NO:43182-10-1| 分子式:C14H13N3| 分子量:223.2731

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产品名称 2-氨基-1-苯甲基苯并咪唑
英文名称2-amino-1-(phenylmethyl)-1H-benzimidazole
CAS编号43182-10-1
产品熔点195-198ºC
产品沸点451.9ºC at 760 mmHg
产品密度1.2g/cm3
产品闪点227.1ºC
精确质量223.11100
PSA43.84000
LogP3.24800
折射率1.661

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危害码 (欧洲) Xn
风险声明 (欧洲) R36/37/38
安全声明 (欧洲) 36/37/39-26
海关编码 2933990090
Name: 2-Amino-1-benzylbenzimidazole 99+% Material Safety Data Sheet
Synonym:
CAS: 43182-10-1
Section 1 - Chemical Product MSDS Name:2-Amino-1-benzylbenzimidazole 99+% Material Safety Data Sheet
Synonym:

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
43182-10-1 2-Amino-1-benzylbenzimidazole >99 256-130-5
Hazard Symbols: None Listed.
Risk Phrases: None Listed.

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Store in a cool, dry place. Keep container closed when not in use.
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels.
Exposure Limits CAS# 43182-10-1: Personal Protective Equipment Eyes: Wear safety glasses and chemical goggles if splashing is possible. Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves and clothing to prevent skin exposure. Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin. Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Crystalline powder
Color: white
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 194.00 - 196.00 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C14H13N3
Molecular Weight: 223.28

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, strong oxidants.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Irritating and toxic fumes and gases.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 43182-10-1 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
2-Amino-1-benzylbenzimidazole - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION


Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
S 28A After contact with skin, wash immediately with
plenty of water.
S 37 Wear suitable gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 43182-10-1: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 43182-10-1 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 43182-10-1 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

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文献:SMITHKLINE BEECHAM CORPORATION Patent: WO2009/39321 A1, 2009 ; Location in patent: Page/Page column 14 ; WO 2009/039321 A1

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文献:Di Braccio, Mario; Grossi, Giancarlo; Signorello, Maria Grazia; Leoncini, Giuliana; Cichero, Elena; Fossa, Paola; Alfei, Silvana; Damonte, Gianluca European Journal of Medicinal Chemistry, 2013 , vol. 62, p. 564 - 578

~68%

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文献:Korbonits, Dezsoe; Kanzel-Szvoboda, Ida; Goenczi, Csaba; Simon, Kalman; Kolonits, Pal Chemische Berichte, 1989 , vol. 122, p. 1107 - 1112

~92%

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文献:Ogunbiyi, O.; Kajbaf, M.; Lamb, J. H.; Jahanshahi, M.; Gorrod, J. W.; Naylor, S. Toxicology Letters, 1995 , vol. 78, # 1 p. 25 - 34

~%

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文献:Guida, Xuan; Jianhua, Han; Xiaomin, Li European Journal of Medicinal Chemistry, 2006 , vol. 41, # 9 p. 1080 - 1083

~17%

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43182-10-1

文献:Korbonits, Dezsoe; Kanzel-Szvoboda, Ida; Goenczi, Csaba; Simon, Kalman; Kolonits, Pal Chemische Berichte, 1989 , vol. 122, p. 1107 - 1112

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