大黄素|cas:518-82-1|西域试剂

大黄素,分析标准品,HPLC≥98.3%

产品编号：西域质检-TM23287| CAS NO：518-82-1| 分子式：C₁₅H₁₀O₅| 分子量：270.237

Emodin大黄素是一种广谱抗癌化合物，Emodin抑制蛋白激酶CKII活性的IC50值为2 μM。Emodin大黄素是癌细胞的广谱抑制剂，包括白血病，肺癌，人舌鳞癌，结肠癌，胆囊癌，胰腺癌，乳腺癌，人宫颈癌和肝癌细胞。大黄素抑制A549，HepG2，OVCAR-3，HeLa和Madin-Darby犬肾（MDCK）细胞的IC50值分别为19.54、12.79、25.82、12.14和5.81 μg/mL。Emodin大黄素以剂量依赖和时间依赖的方式杀死T24和J82细胞，但对HCV-29细胞的毒性较小。体内研究中，Emodin大黄素（50 mg/kg）和顺铂（1 mg/kg）治疗的小鼠的肿瘤明显小于其他组。分析表明大黄素/顺铂组合显著增加了异种移植肿瘤中的细胞凋亡，而没有明显的副作用。

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	包装	价格	库存与货期	购买量	操作
西域质检-TM23287		￥1500.00	杭州北京（现货）
西域质检-TM23287		￥180.00	杭州北京（现货）

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大黄素

Reference Material

This certificate is designed in accordance with ISO 17034 and ISO Guide 31. This reference material (RM) was designed,produced and verified in accordance with ISO/IEC 17025, ISO 17034 and a registered quality management system ISO 9001.

Product Name(产品名称) Emodin

Product Code(产品编号) 716877-100mg

Lot Number(产品批号) 22070785

CAS No. 518-82-1

Mol. Weight(分子量) 270.24

Mol. Formula(分子式) C₁₅H₁₀O₅

Melting Point(熔点) N/A

Expiry Date(失效日期) 2024-Jul-27

Boiling point(沸点) N/A

Appearance(外观) Yellowish Orange Solid_

Storage Temp(存储条件) (2~8)℃,Keep in the shade

C E R T I F I E D

Purity

98.3%

C E R T I F I E D

Expanded Uncertainty (U)

0.5%

Uncertainty

The certified value(s) and uncertainty(ies) are determined in accordance with ISO 17034 with an 95% confidence level(k=2). Uncertainty is based on the Total Combined Uncertainty, including uncertainties of characterisation, homogeneity and stability testing. Stability values are based on real evidence opposed to simulation.

Traceability

The balances used for gravimetric measurements are calibrated with weights traceable to the national standards. The calibration of the balances is verified annually by an external accredited calibration service. This analysis method has been verified using an approach consistent with ISO 17034:2016 & ISO 17025:2017.

CERTIFICATE ON	QC SIGNATURE
2022-Jul-28		RM Release

Method of Identification

HPLC

Method of Identification

HPLC

Intended Use

This RM is intended for use in a laboratory as a calibration and quality control standard or in method development for analytical techniques.

Storage

This reference material meets the specification stated in this certificate until the expiry date, provided it is stored unopened at the recommended temperature here in. If storage after opening is necessary, the RM should be tightly closed and kept from light and moisture.

Hazards

Read Material Safety Data Sheet (MSDS) and understand any potential hazard(s) prior to the use of this product. All chemicals should be considered potentially hazardous in nature and should only be handled by qualified personnel using established good laboratory practices.

Homogeneity

Random replicate samples of the final packaged RM have been analysed to prove homogeneity compliant with ISO 17034.

Instructions for use

It is recommended to use 1 mg as the minimum sample size and if less material is used, to increase the certified uncertainty by a factor of two for half sample and four for a quarter of sample.Visit the support section of our website technology videos and frequently asked questions.

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

符号	GHS07
信号词	Warning
危害声明	H315-H319-H335
警示性声明	P261-P305 + P351 + P338
个人防护装备	dust mask type N95 (US);Eyeshields;Gloves
危害码 (欧洲)	Xi:Irritant
风险声明 (欧洲)	R36/37/38
安全声明 (欧洲)	S26-S36-S37/39
危险品运输编码	NONH for all modes of transport
WGK德国	3
RTECS号	CB7920600
海关编码	2932999099

1. 物质的识别

产品名：	Emodin
CAS号：	518-82-1
制造商/供应商：	西域试剂网站：www.hzbp.cn 邮件：13911702513@139.com

2. 合成/成分数据

产品名：	Emodin
别名：	Frangula emodin
分子式：	C15H10O5
分子量：	270.24

3. 急救措施

吸入后：	如果吸入，移至空气新鲜处，如果呼吸困难，给输氧，如呼吸停止，给予人工呼吸。
皮肤接触后：	用大量的水冲洗，移除污染的衣服和鞋子。
眼睛接触后：	检查并取下隐形眼镜，并用大量的水冲洗；呼叫医生。
吞食后：	如果吞食，用大量纯净水漱口；呼叫医生。

4. 消防措施

适当的灭火剂：	雾状水，二氧化碳，干粉或泡沫。
防护设备：	穿戴自给式呼吸器和防护服，以防止与皮肤和眼睛接触。

5. 泄漏应急处理

安全防范措施：	封锁泄漏区域；穿戴自给式呼吸器，防护服和厚橡胶手套。
清洁/收集措施：	使用液体粘合原料（硅藻土，通用粘合剂）吸取精细粉末；使用酒精擦洗表面和设备除去污渍；根据第11条处理被污染的材料。

6. 处理和储存

安全处理说明：	避免吸入和接触皮肤，眼睛及衣物；材料可能略微具有刺激性。
储存：	粉末型式 -20°C 3年；4°C 2年溶于溶剂 -80°C 6个月；-20°C 1个月

7. 接触控制和个人防护

呼吸设备：	NIOSH / MSHA认可的呼吸器。
双手保护：	耐化学腐蚀的橡胶手套。
眼睛防护：	化学安全护目镜。

8. 稳定性和反应活性

稳定性：	按照说明存储是稳定的；避免强氧化剂。
热分解/其他要避免的情况：	避免光和热。

9. 毒性资料

急性毒性：	无可用资料。
主要刺激性影响：	无可用资料。
在皮肤上：	无可用资料。
对眼睛：	无可用资料；可能具有刺激性。

10. 生态资料

一般注意事项：

无可用资料。

11. 废弃处置

按照所在国家，省份，县市和地方的法规处置。

12. 运输信息

正确的运输名称：	无
非危险品运输：	这种物质被视为非危险品运输。

13. 法规信息

尚未有针对此产品作出的化学安全性评估。

14. 其他信息

上游产品 9
6030-60-0 5018-84-8 14787-38-3 491-60-1
541-47-9 25436-25-3 76695-92-6 76695-89-1
106-51-4
下游产品 10
548-03-8 491-60-1 481-74-3 613-12-7
521-61-9 3775-08-4 3774-64-9 84993-87-3
476-46-0 5018-84-8

97. [3.242] Xu Chenyu et al."The active compound in Rheum officinale Baill, aloe-emodin promotes tomato seedling growth."PLANT GROWTH REGULATION.2023 Mar;:1-14

96. [3.614] Liqing Wang et al."Discovery of the potential neuraminidase inhibitors from Polygonum cuspidatum by ultrafiltration combined with mass spectrometry guided by molecular docking."JOURNAL OF SEPARATION SCIENCE.2023 Mar;:2200937

95. [6.656] Yanchao Xing et al."Cytochrome P450-mediated herb-drug interaction (HDI) of Polygonum multiflorum Thunb. based on pharmacokinetic studies and in vitro inhibition assays."PHYTOMEDICINE.2023 Feb;:154710

94. [3.37] Dingwen Cheng et al."Emodin Alleviates Arthritis Pain through Reducing Spinal Inflammation and Oxidative Stress."Molecular Pain.

93. [6.656] Chong Chen et al."Yishen-Qingli-Huoxue Formula attenuates renal fibrosis by inhibiting indoxyl sulfate via AhR/snai1 signaling."PHYTOMEDICINE.2022 Nov;:154546

92. [IF=3.571] Lin Zhou et al."Comprehensive investigation on the metabolism of emodin both in vivo and in vitro."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.2023 Jan;223:115122

91. [IF=3.614] Li Ji et al."Characterization of the chemical constituents and metabolic profile of Polygonum cuspidatum Sieb. et Zucc. in rat plasma, urine, and feces by ultra-high performance liquid chromatography coupled with Quadrupole-Exactive Orbitrap mass spectrom

90. [IF=3.645] Xi Zhou et al."Preparation of magnetic metal-organic framework MIL-101(Fe) and its application in the extraction of anthraquinones in rhubarb."JOURNAL OF SEPARATION SCIENCE

89. [IF=4.36] Zhenhui Guo et al."Study on the mechanism of Cortex Lycii on lung cancer based on network pharmacology combined with experimental validation."J Ethnopharmacol. 2022 Apr;:115280

88. [IF=5.811] Kong Wei-Song et al."Beware of the Potential Risks for Polygoni Multiflori Caulis-Induced Liver Injury."Front Pharmacol. 2022 Apr;0:928

87. [IF=4.432] Yanqing Wang et al.Emodin prevents renal ischemia-reperfusion injury via suppression of CAMKII/DRP1-mediated mitochondrial fission.Eur J Pharmacol. 2021 Nov;:174603

86. [IF=6.165] Yaofen Li et al.Study on the effects of deep eutectic solvents as a reaction media on the micromorphology of hydrogen-substituted graphyne and its adsorption and electrochemical properties.J Mol Liq. 2021 Nov;:118177

85. [IF=0.986] Ji-le Lan et al."Q-marker Prediction Analysis of Rhubarb in Fengyin Decoction Based on Fingerprint and Network Pharmacology:."Nat Prod Commun. 2021;16(8):

84. [IF=1.618] Tao Yi et al."Simultaneous Quantitation of Five Bioactive Ingredients in Raw and Processed Fallopia multiflora by Employing UHPLC-Q-TOF-MS."J Chromatogr Sci. 2019 Aug;57(7):618-624

83. [IF=1.902] Chenxi Wang et al."Multiple component-pharmacokinetic studies on 10 bioactive constituents of Peiyuan Tongnao capsule using parallel reaction monitoring mode."Biomed Chromatogr. 2021 Oct;35(10):e5153

82. [IF=2.161] Jinjing Li et al."Enhanced hydrophilicity and antifouling performance of PES-C/emodin ultrafiltration membrane:."High Perform Polym. 0;():

81. [IF=2.401] Yongqian Huang et al."The intervention mechanism of emodin on TLR3 pathway in the process of central nervous system injury caused by herpes virus infection."Neurol Res. 2021;43(4):307-313

80. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950

79. [IF=3.205] Jie Tang et al."Metabolite profiling of Shuganzhi tablets in rats and pharmacokinetics study of four bioactive compounds with liquid chromatography combined with electrospray ionization tandem mass spectrometry."J Chromatogr B. 2021 Aug;1179:122827

78. [IF=3.882] Kunpeng Yin et al."Lanthanide Metal–Organic Framework-Based Fluorescent Sensor Arrays to Discriminate and Quantify Ingredients of Natural Medicine."Langmuir. 2021;37(17):5321–5328

77. [IF=3.935] Zhengchao Ji et al."Global identification and quantitative analysis of representative components of Xin-Nao-Kang Capsule, a traditional Chinese medicinal formula, by UHPLC-Q-TOF-MS and UHPLC-TQ-MS."J Pharmaceut Biomed. 2021 May;198:114002

76. [IF=3.935] Li Xie et al."Development of an UHPLC-MS/MS method for comparative pharmacokinetics of nine anthraquinones in rats and application to dosage conversion between different Semen Cassiae forms."J Pharmaceut Biomed. 2019 Sep;174:696

75. [IF=3.935] Yanchao Xing et al."An effective strategy for distinguishing the processing degree of Polygonum multiflorum based on the analysis of substance and taste by LC-MS, ICP-OES and electronic tongue."J Pharmaceut Biomed. 2021 Oct;205:114328

74. [IF=3.943] Yuanyuan Liu et al."Emodin ameliorates ovalbumin-induced airway remodeling in mice by suppressing airway smooth muscle cells proliferation."Int Immunopharmacol. 2020 Nov;88:106855

73. [IF=4.092] Shen Pan et al."Emodin Attenuates Acetaminophen-Induced Hepatotoxicity via the cGAS-STING Pathway."Inflammation. 2021 Aug;:1-14

72. [IF=4.142] Wang Chenxi et al."Systematic quality evaluation of Peiyuan Tongnao capsule by offline two-dimensional liquid chromatography/quadrupole-Orbitrap mass spectrometry and adjusted parallel reaction monitoring of quality markers."Anal Bioanal Chem. 2019 Nov;4

71. [IF=4.36] Li Lin et al."Study on the protection of water extracts of Polygoni Multiflori Radix and Polygoni Multiflori Radix Praeparata against NAFLD and its mechanism."J Ethnopharmacol. 2020 Apr;252:112577

70. [IF=4.759] Yi Zhang et al."Screening of inhibitors against histone demethylation jumonji domain-containing protein 3 by capillary electrophoresis."J Chromatogr A. 2020 Feb;1613:460625

69. [IF=4.759] Yueping Jiang et al."Application of multifold characteristic ion filtering combined with statistical analysis for comprehensive profiling of chemical constituents in anti-renal interstitial fibrosis I decoction by ultra-high performance liquid chromatogra

68. [IF=5.645] Li-Xia Dai et al."Ultrasound-assisted extraction of five anthraquinones from Rheum palmatum water extract residues and the antimicrobial activities."Ind Crop Prod. 2021 Apr;162:113288

67. [IF=5.81] Zhihui Yin et al."Rhein Relieves Oxidative Stress in an Aβ1-42 Oligomer-Burdened Neuron Model by Activating the SIRT1/PGC-1α-Regulated Mitochondrial Biogenesis."Front Pharmacol. 2021; 12: 746711

66. [IF=5.81] Zhang N et al."Emodin Inhibits the Proliferation of MCF-7 Human Breast Cancer Cells Through Activation of Aryl Hydrocarbon Receptor (AhR).."Front Pharmacol. 2020 Jan;11:622046-622046

65. [IF=6.165] Neng Qiu et al."Inclusion complex of emodin with hydroxypropyl-β-cyclodextrin: Preparation, physicochemical and biological properties."J Mol Liq. 2019 Sep;289:111151

64. [IF=9.811] Manjie Gao et al."High-Crystallinity Covalent Organic Framework Synthesized in Deep Eutectic Solvent: Potentially Effective Adsorbents Alternative to Macroporous Resin for Flavonoids."Chem Mater. 2021;33(20):8036–8051

63. [IF=1.773] Li-Hua ZHOU et al."Label-free quantitative proteomics reveals fibrinopeptide B and heparin cofactor II as potential serum biomarkers in respiratory syncytial virus-infected mice treated with Qingfei oral liquid formula."Chin J Nat Medicines. 2018 Apr;16:2

62. [IF=1.843] Ma Libin et al."Emodin ameliorates renal fibrosis in rats via TGF-β1/Smad signaling pathway and function study of Smurf 2."Int Urol Nephrol. 2018 Feb;50(2):373-382

61. [IF=3.361] Lailai Li et al."Development of a dual screening strategy to identify pro-angiogenic compounds from natural products: application on Tongmai Yangxin Pills."Rsc Adv. 2016 Dec;6(116):115308-115316

60. [IF=3.366] Wu Xingqiang et al."A Novel Selective Accelerated Solvent Extraction for Effective Separation and Rapid Simultaneous Determination of Six Anthraquinones in Tartary Buckwheat and Its Products by UPLC–DAD."Food Anal Method. 2015 May;8(5):1124-1132

59. [IF=3.738] Selma Houchi et al."Investigation of common chemical components and inhibitory effect on GES-type β-lactamase (GES22) in methanolic extracts of Algerian seaweeds."Microb Pathogenesis. 2019 Jan;126:56

58. [IF=4.366] Longfei Lin et al."Inhibition of Mitochondrial Complex Function—The Hepatotoxicity Mechanism of Emodin Based on Quantitative Proteomic Analyses."Cells-Basel. 2019 Mar;8(3):263

57. [IF=4.411] Yanling Zeng et al."Rapid Characterization of Components in Bolbostemma paniculatum by UPLC/LTQ-Orbitrap MSn Analysis and Multivariate Statistical Analysis for Herb Discrimination."Molecules. 2018 May;23(5):1155

56. [IF=4.743] Hua Jun-yi et al."Emodin prevents intima thickness via Wnt4/Dvl-1/β-catenin signaling pathway mediated by miR-126 in balloon-injured carotid artery rats."Exp Mol Med. 2015 Jun;47(6):e170-e170

55. [IF=5.64] Wu Dousheng et al."Oleanolic Acid Induces the Type III Secretion System of Ralstonia solanacearum."Front Microbiol. 2015 Dec;0:1466

54. [IF=5.645] Fangyuan Gao et al."Cyclodextrin-based ultrasonic-assisted microwave extraction and HPLC-PDA-ESI-ITMSn separation and identification of hydrophilic and hydrophobic components of Polygonum cuspidatum: A green, rapid and effective process."Ind Crop Prod. 20

53. [IF=9.229] Qing-Shan Liu et al."Novel Beta-Tubulin-Immobilized Nanoparticles Affinity Material for Screening β-Tubulin Inhibitors from a Complex Mixture."Acs Appl Mater Inter. 2017;9(7):5725–5732

52. Zhou, Li-Hua, et al. "Label-free quantitative proteomics reveals fibrinopeptide B and heparin cofactor II as potential serum biomarkers in respiratory syncytial virus-infected mice treated with Qingfei oral liquid formula." Chin J Nat Med 16 (2018): 241-25

51. Zhou, Li-Hua, et al. "Label-free quantitative proteomics reveals fibrinopeptide B and heparin cofactor II as potential serum biomarkers in respiratory syncytial virus-infected mice treated with Qingfei oral liquid formula." Chin J Nat Med 16 (2018): 241-25

50. Huang, Xiya, Weixi Cai, and Baojun Xu. "Kinetic changes of nutrients and antioxidant capacities of germinated soybean (Glycine max L.) and mung bean (Vigna radiata L.) with germination time." Food chemistry 143 (2014): 268-276.https://doi.org/10.1016/j.foo

49. LIU, Qing-Shan, et al. Novel Beta-Tubulin-Immobilized Nanoparticles Affinity Material for Screening β-Tubulin Inhibitors from a Complex Mixture. ACS applied materials & interfaces, 2017, 9.7: 5725-5732.https://doi.org/10.1021/acsami.6b13477

48. Zhang, Ning, et al. "Emodin inhibits the proliferation of human breast cancer MCF-7 cells through activation of aryl hydrocarbon receptor." Frontiers in Pharmacology 11 (2020): 2372.https://doi.org/10.3389/fphar.2020.622046

47. Qiu, Neng, et al. "Inclusion complex of emodin with hydroxypropyl-β-cyclodextrin: Preparation, physicochemical and biological properties." Journal of Molecular Liquids 289 (2019): 111151.https://doi.org/10.1016/j.molliq.2019.111151

46. Lin, Longfei, et al. "Inhibition of Mitochondrial Complex Function—The Hepatotoxicity Mechanism of Emodin Based on Quantitative Proteomic Analyses." Cells 8.3 (2019): 263.https://doi.org/10.3390/cells8030263

45. Huang, Yongqian, et al. "The intervention mechanism of emodin on TLR3 pathway in the process of central nervous system injury caused by herpes virus infection." Neurological Research 43.4 (2021): 307-313.https://doi.org/10.1080/01616412.2020.1853989

44. Wang, Qi, et al. "Identification and characterization of the structure–activity relationships involved in UGT1A1 inhibition by anthraquinone and dianthrone constituents of Polygonum multiflorum." Scientific reports 7.1 (2017): 1-9.

43. Gao, Fangyuan, et al. "Cyclodextrin-based ultrasonic-assisted microwave extraction and HPLC-PDA-ESI-ITMSn separation and identification of hydrophilic and hydrophobic components of Polygonum cuspidatum: A green, rapid and effective process." Industrial Cro

42. 张明明. 大黄道地产区核心种质构建及优良种质筛选研究[D].北京中医药大学,2020.

41. 汪颖舒,朱广灏,王冰,李杰荣,骆前飞,何修滢,赵佳逸,修彦凤.古法黑豆蒸晒与药典黑豆汁连续蒸对何首乌中12个成分含量的影响[J].中草药,2020,51(19):4972-4982.

40. 王盼,储全根,轩云,蔡正银.抵当陷胸汤HPLC-MS指纹图谱研究[J].时珍国医国药,2020,31(12):2937-2940.

39. 李承浩,王萌,任晓亮.磺化杯6芳烃对4类中药单体成分增溶作用及其机制研究[J].中国现代中药,2020,22(12):2032-2038.

38. 佘瑶瑶,刘自华,张颖,刘义梅,陈运中.湖北虎杖主要化学成分的含量分析及其与色差的相关性研究[J].食品安全质量检测学报,2021,12(03):960-967.

37. 周桂,谢瑞芳,于天源,周昕.首乌藤指纹图谱的建立及3种成分的测定[J].中医药导报,2020,26(13):27-32.

36. 宁一博,程龙,黄芷棋,贺润铖,孙建宁,董世芬.基于脂肪棕色化探究大黄素对老龄小鼠脂质代谢的影响[J].中南药学,2021,19(03):478-483.

35. 陆杰,王婷婷,梁琨,安叡,王新宏,陈颖.UPLC-LTQ-Orbitrap-MS法分析大承气汤化学成分[J].中成药,2020,42(12):3275-3280.

34. 陈静.pH响应的铜-大黄素脂质体的制备及其体外释放研究[J].江苏科技信息,2020,37(31):52-54.

33. 周军, 彭媚, 陈薇,等. 药用虎杖剩余物的化学组成与热解特性[J]. 环境工程学报, 2018, 12(12):229-237.

32. 刘全德,唐仕荣,宋慧,王营,邢洪伟.芦荟蒽醌类化合物的超声提取及其抗氧化性研究[J].食品与机械,2011,27(05):68-71.

31. 郭允, 陈永超, 李晓花,等. 牛黄解毒片中6种指标成分的含量测定[J]. 沈阳药科大学学报, 2016(6):454-458.

30. 杨强蒲晓辉李晓花. 一清胶囊中7种指标成分的测定[J]. 华西药学杂志 2017(3).

29. 李晓花郭允李佳袁琦蒲晓辉王高峰.RP-HPLC法同时测定三黄片中7种指标成分的含量[J].沈阳药科大学学报 2016 33(08):637-642.

28. 魏艳婷张静宜张华潭等. HPLC法同时测定三黄滴丸中5种蒽醌类成分的含量[J]. 中国药房 2015.

27. 程素盼张敏敏梁琰等. HPLC-DAD-ESI-TOF/MS法分析安神补脑液中化学成分[J]. 中成药 2019 041(004):743-748.

26. 李红英向极钎龙澜等. HPLC法测定大黄药材中5种游离蒽醌的含量[J]. 安徽农业科学 2013(12):5278-5279.

25. 徐艳, 张心怡, 狄留庆,等. 基于热熔挤出技术的虎杖提取物速释固体分散体制备研究[J]. 中草药, 2017(23):4865-4871.

24. 周杨静,唐俊峰,高峰,卫培峰.基于“九蒸九晒”炮制法的何首乌主要化学成分含量变化及对大鼠肝脏的影响实验研究[J].中南药学,2020,18(04):543-548.

23. 杨国静张珞琪陈随清等. 不同商品规格决明子的质量分析[J]. 中国现代中药 2018 v.20(08):963-967.

22. 支旭然刘洪涛吴茵等. UPLC-MS/MS法同时测定肾康注射液中7个有效成分[J]. 药物分析杂志 2017 037(001):37-42.

21. 支旭然, 白万军, 王祁民,等. 肾康注射液的配伍稳定性考察[J]. 中国药师, 2016, 19(011):2155-2157.

20. 林艳, 刘月新, 李春,等. 生/制何首乌HPLC指纹图谱结合模式识别与含量测定的质量控制研究[J]. 中国中医药信息杂志, 2018, 25(12):67-71.

19. 王亚洲, 吴洪文. 烫伤合剂质量标准研究[J]. 中国医院药学杂志, 2012, 32(021):1767-1769.

18. 蔡芳, 任繁栋, 任达兵,等. 整合定性策略用于大黄素代谢物的高通量靶向鉴定[J]. 分析化学, 2019, 047(008):1212-1218.

17. 李宵吴茵支旭然等. UPLC-MS/MS法同时测定苦黄注射液中7种成分的含量[J]. 中国药房 2017 028(015):2108-2112.

16. 支旭然董占军吴茵等. HPLC同时测定肾康注射液中的4种成分[J]. 华西药学杂志 2017(03):297-299.

15. 张蕾, 郭晏华, 黄婷,等. 虎杖生品及不同炮制品中虎杖苷、白藜芦醇和大黄素含量[J]. 辽宁中医药大学学报, 2013, 015(011):56-59.

14. 顾玲, 闫璟, 柯苗,等. 芦丁在聚大黄素/纳米氧化锌修饰碳糊电极上的电化学行为研究[J]. 化学研究与应用, 2017(10).

13. 李成职, 刘洋, 刘小红,等. 消痔方醇提工艺和颗粒制剂含量测定方法[J]. 青岛大学学报(工程技术版), 2018, 033(001):130-134.

12. 张丹参, 梅艳飞, 宋晓敏,等. 大黄结肠靶向微丸的制备及处方优化[J]. 中草药, 2016, 47(008):1321-1326.

11. 张丹参, 梅艳飞, 宋晓敏,等. 大黄结肠靶向微丸在大鼠胃肠道内的分布及释放方法学研究[J]. 神经药理学报, 2015, 5(005):20-27.

10. 赵滋苗, 蔡宛如, 陆军,等. 大黄素对脓毒症大鼠血糖和胰岛素抵抗的影响[J]. 中国现代应用药学, 2016, 33(009):1115-1118.

9. 韦美金,黄娟,白俊其,蔡锡潮,丘小惠.大黄素对大鼠血清肝功能、肝脏转运蛋白及代谢酶UGT1A1表达的影响[J].时珍国医国药,2018,29(07):1551-1555.

8. 豆颖, 闫哲, 潘翔珍,等. 大黄素对口腔鳞癌细胞Tca8113抑制作用[J]. 医药论坛杂志, 2015(01):72-74.

7. 郝宗艳, 李欣, 李玲. 大黄素对功能性消化不良大鼠相关指标影响的实验研究[J]. 新中医, 2017, 049(005):1-3.

6. 王云龙, 郭海, 魏睦新. 大黄素对CCl4诱导小鼠肝纤维化的作用机制[J]. 中国现代中药, 2018, 20(04):402-408.

5. 李灵玲, 蒲吉, LI,等. 大黄素促进结肠癌细胞自噬性凋亡的作用及其机制[J]. 华西药学杂志, 2017, 06(v.32):46-49

4. 江坤, 李璐, 李菁,等. 基于抗炎药效的中药榕须质量评价研究[J]. 中国药学杂志, 2016, 051(012):1033-1038.

3. 孟雨婷, 李华, 陈志颖,等. 基于成分检测的大黄-蜇虫药对最佳配伍比例的研究[J]. 辽宁化工, 2020, v.49;No.459(01):32-36.

2. 葛朝亮程钢余剑萍许杜娟.“九蒸九晒”传统炮制对何首乌主要化学成分的影响[J].现代中药研究与实践 2017 31(03):43-47.

1. 陈帅王慧竹薛健飞等. HPLC-DAD法同时测定四季三黄丸中9种成分[J]. 中成药 2016(8期):1727-1731.