大黄酸|Rhein|cas:478-43-3|西域试剂

大黄酸,Rhein,分析标准品,HPLC≥99%

产品编号：西域质检-TM78076| CAS NO：478-43-3| 分子式：C₁₅H₈O₆| 分子量：284.220

Rhein是一种蒽醌类化合物，是从Rheum coreanum Nakai新鲜根茎分离得到的，具有抗炎、抗氧化、抗癌等作用。Rhein（0.1和1 mg/mL）显著抑制人结肠腺癌细胞（Caco-2）中的细胞增殖和丝裂原活化蛋白（MAP）激酶活化，但显著减少H2O2诱导的DNA损伤和H2O2/Fe2+诱导的MDA和ROS水平升高，浓度为0.1-10 mg/mL。Rhein在35 μM下能够有效抑制人类骨关节炎滑膜中IL-1β的合成，通过减少软骨细胞IL-1R的数量并抑制IL-1β诱导的软骨细胞和软骨中NO产生，而抑制该细胞因子在软骨水平的作用。 Rhein大黄酸（150 mg/kg/d，口服）显著改善肾间质纤维化病变，减轻单侧输尿管梗阻所致肾间质纤维化小鼠α-SMA的表达和纤维连接蛋白（FN）的沉积。Rhein也能够有效改善糖尿病肾脏病变，并有效减弱高血脂症，降低转化生长因子-β1(TGF-β1)和肾组织中纤维连接蛋白免疫组织化学表达，降低血浆中胆固醇(Chol)，甘油三酸酯(TG)，低密度脂蛋白胆固醇(LDL-C)和载脂蛋白E。

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	包装	价格	库存与货期	购买量	操作
西域质检-TM78076		￥190.00	杭州北京（现货）

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大黄酸

Reference Material

This certificate is designed in accordance with ISO 17034 and ISO Guide 31. This reference material (RM) was designed,produced and verified in accordance with ISO/IEC 17025, ISO 17034 and a registered quality management system ISO 9001.

Product Name(产品名称) Rhein(4,5-二羟蒽醌-2-羧酸)

Product Code(产品编号) 78076-20mg

Lot Number(产品批号) 23020232

CAS No. 478-43-3

Mol. Weight(分子量) 284.22

Mol. Formula(分子式) C₁₅H₈O₆

Melting Point(熔点) N/A

Expiry Date(失效日期) 2029-Feb-16

Boiling point(沸点) N/A

Appearance(外观) Orange Solid
(橙色固体)____________

Storage Temp(存储条件) (-18±5)℃,Keep in the shade
冷冻(-18±5)℃,置于阴凉处

C E R T I F I E D

Purity

99%

C E R T I F I E D

Expanded Uncertainty (U)

0.5%

Uncertainty

The certified value(s) and uncertainty(ies) are determined in accordance with ISO 17034 with an 95% confidence level(k=2). Uncertainty is based on the Total Combined Uncertainty, including uncertainties of characterisation, homogeneity and stability testing. Stability values are based on real evidence opposed to simulation.

Traceability

The balances used for gravimetric measurements are calibrated with weights traceable to the national standards. The calibration of the balances is verified annually by an external accredited calibration service. This analysis method has been verified using an approach consistent with ISO 17034:2016 & ISO 17025:2017.

CERTIFICATE ON	QC SIGNATURE
2023-Feb-17		RM Release

Method of Identification

HPLC

Method of Identification

HPLC

Intended Use

This RM is intended for use in a laboratory as a calibration and quality control standard or in method development for analytical techniques.

Storage

This reference material meets the specification stated in this certificate until the expiry date, provided it is stored unopened at the recommended temperature here in. If storage after opening is necessary, the RM should be tightly closed and kept from light and moisture.

Hazards

Read Material Safety Data Sheet (MSDS) and understand any potential hazard(s) prior to the use of this product. All chemicals should be considered potentially hazardous in nature and should only be handled by qualified personnel using established good laboratory practices.

Homogeneity

Random replicate samples of the final packaged RM have been analysed to prove homogeneity compliant with ISO 17034.

Instructions for use

It is recommended to use 1 mg as the minimum sample size and if less material is used, to increase the certified uncertainty by a factor of two for half sample and four for a quarter of sample.Visit the support section of our website technology videos and frequently asked questions.

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

符号	GHS07
信号词	Warning
危害声明	H315-H319-H335
警示性声明	P305 + P351 + P338
个人防护装备	dust mask type N95 (US);Eyeshields;Gloves
危害码 (欧洲)	Xi
风险声明 (欧洲)	R36/37/38:Irritating to eyes, respiratory system and skin .
安全声明 (欧洲)	S26-S37/39
危险品运输编码	NONH for all modes of transport
WGK德国	2
RTECS号	CA9516000
海关编码	2918990090

1. 物质的识别

产品名：	Rhein
CAS号：	478-43-3
制造商/供应商：	西域试剂网站：www.hzbp.cn 邮件：13911702513@139.com

2. 合成/成分数据

产品名：	Rhein
别名：	Cassic acid; Rheic Acid; Monorhein; NSC 38629
分子式：	C15H8O6
分子量：	284.22

3. 急救措施

吸入后：	如果吸入，移至空气新鲜处，如果呼吸困难，给输氧，如呼吸停止，给予人工呼吸。
皮肤接触后：	用大量的水冲洗，移除污染的衣服和鞋子。
眼睛接触后：	检查并取下隐形眼镜，并用大量的水冲洗；呼叫医生。
吞食后：	如果吞食，用大量纯净水漱口；呼叫医生。

4. 消防措施

适当的灭火剂：	雾状水，二氧化碳，干粉或泡沫。
防护设备：	穿戴自给式呼吸器和防护服，以防止与皮肤和眼睛接触。

5. 泄漏应急处理

安全防范措施：	封锁泄漏区域；穿戴自给式呼吸器，防护服和厚橡胶手套。
清洁/收集措施：	使用液体粘合原料（硅藻土，通用粘合剂）吸取精细粉末；使用酒精擦洗表面和设备除去污渍；根据第11条处理被污染的材料。

6. 处理和储存

安全处理说明：	避免吸入和接触皮肤，眼睛及衣物；材料可能略微具有刺激性。
储存：	粉末型式 -20°C 3年；4°C 2年溶于溶剂 -80°C 6个月；-20°C 1个月

7. 接触控制和个人防护

呼吸设备：	NIOSH / MSHA认可的呼吸器。
双手保护：	耐化学腐蚀的橡胶手套。
眼睛防护：	化学安全护目镜。

8. 稳定性和反应活性

稳定性：	按照说明存储是稳定的；避免强氧化剂。
热分解/其他要避免的情况：	避免光和热。

9. 毒性资料

急性毒性：	无可用资料。
主要刺激性影响：	无可用资料。
在皮肤上：	无可用资料。
对眼睛：	无可用资料；可能具有刺激性。

10. 生态资料

一般注意事项：

无可用资料。

11. 废弃处置

按照所在国家，省份，县市和地方的法规处置。

12. 运输信息

正确的运输名称：	无
非危险品运输：	这种物质被视为非危险品运输。

13. 法规信息

尚未有针对此产品作出的化学安全性评估。

14. 其他信息

上游产品 9
13739-02-1 481-74-3 1402610-53-0 481-72-1
6155-37-9 820243-51-4 109650-18-2 820243-52-5
820243-54-7
下游产品 3
117-10-2 13739-02-1 72049-24-2

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1. 支旭然董占军吴茵等. HPLC同时测定肾康注射液中的4种成分[J]. 华西药学杂志 2017(03):297-299.