天然产物/人参皂苷Rd|cas:52705-93-8|西域试剂

天然产物/人参皂苷Rd,≥98.0%

产品编号：西域质检-TM38259| CAS NO：52705-93-8| 分子式：C₄₈H₈₂O₁₈| 分子量：947.154

Ginsenoside Rd 抑制 TNFα 诱导的 NF-κB 转录活性，IC50 为 12.05±0.82 μM。Ginsenoside Rd 抑制 COX-2 和 iNOS mRNA 的表达。Ginsenoside Rd 还抑制 Ca2+ 内流。Ginsenoside Rd 抑制CYP2D6，CYP1A2，CYP3A4 和 CYP2C9，IC50 分别为 58.0±4.5 μM，78.4±5.3 μM，81.7±2.6 μM 和 85.1±9.1 μM。

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	包装	价格	库存与货期	购买量	操作
西域质检-TM38259		￥112.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

天然产物/人参皂苷Rd

Reference Material

This certificate is designed in accordance with ISO 17034 and ISO Guide 31. This reference material (RM) was designed,produced and verified in accordance with ISO/IEC 17025, ISO 17034 and a registered quality management system ISO 9001.

Product Name(产品名称) Ginsenoside Rd(人参皂苷Rd)

Product Code(产品编号) 716977-20mg

Lot Number(产品批号) -

CAS No. 52705-93-8

Mol. Weight(分子量) 947.15

Mol. Formula(分子式) C₄₈H₈₂O₁₈

Melting Point(熔点) N/A

Expiry Date(失效日期) -

Boiling point(沸点) N/A

Appearance(外观) White to Off-White Solid
(白色固体)

Storage Temp(存储条件) (2~8)℃,dark
冷藏(2~8)℃避光

C E R T I F I E D

Purity

99.1%

C E R T I F I E D

Expanded Uncertainty (U)

0.8%

Uncertainty

The certified value(s) and uncertainty(ies) are determined in accordance with ISO 17034 with an 95% confidence level(k=2). Uncertainty is based on the Total Combined Uncertainty, including uncertainties of characterisation, homogeneity and stability testing. Stability values are based on real evidence opposed to simulation.

Traceability

The balances used for gravimetric measurements are calibrated with weights traceable to the national standards. The calibration of the balances is verified annually by an external accredited calibration service. This analysis method has been verified using an approach consistent with ISO 17034:2016 & ISO 17025:2017.

CERTIFICATE ON	QC SIGNATURE
-		RM Release

Method of Identification

HPLC

Method of Identification

HPLC

Intended Use

This RM is intended for use in a laboratory as a calibration and quality control standard or in method development for analytical techniques.

Storage

This reference material meets the specification stated in this certificate until the expiry date, provided it is stored unopened at the recommended temperature here in. If storage after opening is necessary, the RM should be tightly closed and kept from light and moisture.

Hazards

Read Material Safety Data Sheet (MSDS) and understand any potential hazard(s) prior to the use of this product. All chemicals should be considered potentially hazardous in nature and should only be handled by qualified personnel using established good laboratory practices.

Homogeneity

Random replicate samples of the final packaged RM have been analysed to prove homogeneity compliant with ISO 17034.

Instructions for use

It is recommended to use 1 mg as the minimum sample size and if less material is used, to increase the certified uncertainty by a factor of two for half sample and four for a quarter of sample.Visit the support section of our website technology videos and frequently asked questions.

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

符号	GHS07
信号词	Warning
危害声明	H302
危害码 (欧洲)	Xn
风险声明 (欧洲)	R22
安全声明 (欧洲)	S2-S45
危险品运输编码	NONH for all modes of transport

1. 物质的识别

产品名：	Ginsenoside-Rd
CAS号：	52705-93-8
制造商/供应商：	西域试剂网站：www.hzbp.cn 邮件：13911702513@139.com

2. 合成/成分数据

产品名：	Ginsenoside-Rd
别名：	Gypenoside VIII
分子式：	C48H82O18
分子量：	947.15

3. 急救措施

吸入后：	如果吸入，移至空气新鲜处，如果呼吸困难，给输氧，如呼吸停止，给予人工呼吸。
皮肤接触后：	用大量的水冲洗，移除污染的衣服和鞋子。
眼睛接触后：	检查并取下隐形眼镜，并用大量的水冲洗；呼叫医生。
吞食后：	如果吞食，用大量纯净水漱口；呼叫医生。

4. 消防措施

适当的灭火剂：	雾状水，二氧化碳，干粉或泡沫。
防护设备：	穿戴自给式呼吸器和防护服，以防止与皮肤和眼睛接触。

5. 泄漏应急处理

安全防范措施：	封锁泄漏区域；穿戴自给式呼吸器，防护服和厚橡胶手套。
清洁/收集措施：	使用液体粘合原料（硅藻土，通用粘合剂）吸取精细粉末；使用酒精擦洗表面和设备除去污渍；根据第11条处理被污染的材料。

6. 处理和储存

安全处理说明：	避免吸入和接触皮肤，眼睛及衣物；材料可能略微具有刺激性。
储存：	粉末型式 -20°C 3年；4°C 2年溶于溶剂 -80°C 6个月；-20°C 1个月

7. 接触控制和个人防护

呼吸设备：	NIOSH / MSHA认可的呼吸器。
双手保护：	耐化学腐蚀的橡胶手套。
眼睛防护：	化学安全护目镜。

8. 稳定性和反应活性

稳定性：	按照说明存储是稳定的；避免强氧化剂。
热分解/其他要避免的情况：	避免光和热。

9. 毒性资料

急性毒性：	无可用资料。
主要刺激性影响：	无可用资料。
在皮肤上：	无可用资料。
对眼睛：	无可用资料；可能具有刺激性。

10. 生态资料

一般注意事项：

无可用资料。

11. 废弃处置

按照所在国家，省份，县市和地方的法规处置。

12. 运输信息

正确的运输名称：	无
非危险品运输：	这种物质被视为非危险品运输。

13. 法规信息

尚未有针对此产品作出的化学安全性评估。

14. 其他信息

88140-39-0

52705-93-8

文献：Kitagawa; Taniyama; Yoshikawa; Ikenishi; Nakagawa Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 11 p. 2961 - 2970

88140-37-8

52705-93-8

文献：Kitagawa; Taniyama; Yoshikawa; Ikenishi; Nakagawa Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 11 p. 2961 - 2970

88140-34-5

52705-93-8

文献：Kitagawa; Taniyama; Yoshikawa; Ikenishi; Nakagawa Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 11 p. 2961 - 2970

88140-38-9

52705-93-8

文献：Kitagawa; Taniyama; Yoshikawa; Ikenishi; Nakagawa Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 11 p. 2961 - 2970

上游产品 4
88140-39-0 88140-37-8 88140-34-5 88140-38-9
下游产品 0

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73. [IF=5.811] He Zhang et al."Prevention Effect of Protopanaxadiol-Type Saponins Saponins and Protopanaxatriol-Type Saponins on Myelosuppression Mice Induced by Cyclophosphamide.."Frontiers in Pharmacology. 2022 Apr;13:845034-845034

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67. [IF=4.432] Shuai Zhang et al."Ginsenoside Rf inhibits human tau proteotoxicity and causes specific LncRNA, miRNA and mRNA expression changes in Caenorhabditis elegans model of tauopathy."Eur J Pharmacol. 2022 May;922:174887

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50. [IF=5.002] Lu Yao et al."Ginsenoside Rd Ameliorates High Fat Diet-Induced Obesity by Enhancing Adaptive Thermogenesis in a cAMP-Dependent Manner."Obesity. 2020 Apr;28(4):783-792

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29. Yongshen Ren, Jiao Ai, Xinqiao Liu, Shuai Liang, Yao Zheng, Xin Deng, Yan Li, Jing Wang, Xukun Deng, Lin-Lin Chen, Anticoagulant active ingredients identification of total saponin extraction of different Panax medicinal plants based on grey relational anal

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27. Jin, Wenqi, et al. "Ginsenoside Rd attenuates ACTH-induced corticosterone secretion by blocking the MC2R-cAMP/PKA/CREB pathway in Y1 mouse adrenocortical cells." Life sciences 245 (2020): 117337.https://doi.org/10.1016/j.lfs.2020.117337

26. Zhengming Qian, Qi Huang, Chunhong Li, Jing Chen, Gang Li, Hongyan Ma & Juying Xie (2020) Analysis of ginseng root and leaf by multiple columns and detections liquid chromatography, Journal of Liquid Chromatography & Related Technologies, 43:13-14, 464-473

25. Bian, Minjuan, et al. "Combination of ginsenoside Rb1 and Rd protects the retina against bright light-induced degeneration." Scientific reports 7.1 (2017): 1-15.https://doi.org/10.1038/s41598-017-06471-x

24. Han, Xin, et al. "Biocatalytic production of compound K in a deep eutectic solvent based on choline chloride using a substrate fed-batch strategy." Bioresource technology 305 (2020): 123039.https://doi.org/10.1016/j.biortech.2020.123039

23. Yao, Lu, et al. "Ginsenoside Rd ameliorates high fat diet‐induced obesity by enhancing adaptive thermogenesis in a cAMP‐dependent manner." Obesity 28.4 (2020): 783-792.https://doi.org/10.1002/oby.22761

22. 王艳,尉忠贤,李晶.HPLC法测定不同厂家振源片中人参皂苷的含量[J].西北药学杂志,2020,35(05):669-673.

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20. 屈青松,林峰,赵崇妍,马涛,宋帅,史新元.发酵乳杆菌发酵人参工艺优化及人参皂苷抗氧化活性测定[J].中成药,2020,42(10):2738-2743.

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17. 邵紫君,李志满,于鹏程,陈建波,李珊珊,孙印石.氨基酸转化三七花中稀有人参皂苷及提取液对脂多糖诱导的RAW264.7细胞活性的影响[J].中草药,2021,52(03):702-710.

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1. 薛晓丽, 张心慧, 于加平, et al. 重金属胁迫对人参皂苷含量的影响.

天然产物/人参皂苷Rd,≥98.0%

天然产物/人参皂苷Rd

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