人参皂甙 Rd, 分析对照品|Ginsenoside Rd|cas:52705-93-8|西域试剂

人参皂甙 Rd, 分析对照品,Ginsenoside Rd

产品编号：西域试剂-WR343479| CAS NO：52705-93-8| 分子式：C₄₈H₈₂O₁₈| 分子量：947.15

Ginsenoside Rd 抑制 TNFα 诱导的 NF-κB 转录活性，IC50 为 12.05±0.82 μM。Ginsenoside Rd 抑制 COX-2 和 iNOS mRNA 的表达。Ginsenoside Rd 还抑制 Ca2+ 内流。Ginsenoside Rd 抑制CYP2D6，CYP1A2，CYP3A4 和 CYP2C9，IC50 分别为 58.0±4.5 μM，78.4±5.3 μM，81.7±2.6 μM 和 85.1±9.1 μM。

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	包装	价格	库存与货期	购买量	操作
西域试剂-WR343479		￥522.00	杭州北京（现货）
西域试剂-WR343479		￥1635.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

产品名称

人参皂甙 Rd, 分析对照品

英文名称

Ginsenoside Rd

CAS编号

52705-93-8

产品描述

产品熔点

207 °C(dec.)

产品沸点

1015.6±65.0 °C at 760 mmHg

产品密度

1.4±0.1 g/cm3

产品闪点

568.0±34.3 °C

精确质量

946.550110

PSA

298.14000

LogP

3.24

外观性状

白色粉末（乙醇-乙酸乙酯 1:1）

蒸气压

0.0±0.6 mmHg at 25°C

折射率

1.611

溶解性

DMSO : 100 mg/mL (105.58 mM; Need ultrasonic)

溶解性数据

In Vitro:

DMSO : 100 mg/mL (105.58 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.0558 mL	5.2790 mL	10.5580 mL
5 mM	0.2112 mL	1.0558 mL	2.1116 mL
10 mM	0.1056 mL	0.5279 mL	1.0558 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (2.64 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (2.64 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (2.64 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (2.64 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (2.64 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (2.64 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在西域网站选购。

靶点

NF-κB:12.05 μM (IC50, in HepG2 cells)

COX-2

L-type calcium channel

CYP2D6:58 μM (IC50)

CYP1A2:78.4 μM (IC50)

CYP3A4:81.7 μM (IC50)

CYP2C9:85.1 μM (IC50)

体外研究

人参皂苷（Ginsenoside Rd）是人参最丰富的成分之一。人参皂甙Rd显着抑制TNF-α诱导的NF-κB转录活性，HepG2细胞的IC50为12.05±0.82。人参皂甙Rd还以剂量依赖性方式抑制COX-2和iNOS mRNA以及iNOS启动子活性的表达。为了确定无毒浓度，用各种浓度（0.1,1和10μM）的化合物（例如，人参皂甙Rd）处理HepG2细胞，并使用MTS测定法测量细胞活力。没有化合物在高达10μM时具有显着的细胞毒性，表明NF-κB抑制不是由细胞毒性引起的。人参皂苷Rd是人参中最丰富的成分之一，通过多种机制保护心脏，包括抑制Ca2 +内流。人参皂甙Rd以浓度依赖性方式降低ICa，L峰值振幅（IC50 = 32.4±7.1μM）。人参皂苷Rd对人肝微粒体中CYP2D6的活性具有抑制作用，IC50为58.0±4.5μM，对人肝微粒体中CYP1A2，CYP3A4和CYP2C9活性的抑制作用较弱，IC50分别为78.4±5.3,81.7±2.6分别为85.1±9.1，对人肝微粒体中CYP2A6活性的抑制作用更弱，IC50值大于100μM。

体内研究

Ginsenosides Rd是从绞股蓝中分离出的主要化合物，可在整体上改善肠道微环境并诱导ApcMin / +小鼠的抗息肉病。在肠息肉出现之前，对6周龄小鼠进行人参皂苷Rd处理。监测所有小鼠的食物摄入量，耗水量和体重变化。在整个实验中，未观察到小鼠中Rb3 /人参皂苷Rd相关的体重减轻。此外，没有一只处理过的小鼠表现出食物和水消耗的变化。然而，人参皂甙Rd处理有效地减少了息肉的数量和大小。

细胞实验

MTS测定用于分析化合物对细胞活力的影响。将HepG2细胞在96孔板（1×10 4细胞/孔）中培养过夜。在添加化合物（例如，人参皂苷Rd; 0.1,1和10μM）24小时后评估细胞活力。在加入MTS 30分钟后，活细胞数由溶解的甲product产物的A490nm确定。

动物实验

*下述溶液配置方法仅为基于分子量计算出的理论值。不同产品在配置溶液前，需考虑其在不同溶剂中的溶解度限制。

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.0558 mL	5.279 mL	10.558 mL
5 mM	0.2112 mL	1.0558 mL	2.1116 mL
10 mM	0.1056 mL	0.5279 mL	1.0558 mL

不同实验动物依据体表面积的等效剂量转换表（参考来源于公开文献）

	小鼠	大鼠	兔	豚鼠	仓鼠	狗
重量 (kg)	0.02	0.15	1.8	0.4	0.08	10
体表面积 (m²)	0.007	0.025	0.15	0.05	0.02	0.5
K_m 系数	3	6	12	8	5	20

动物 A (mg/kg) = 动物 B (mg/kg) ×	动物 B的K_m系数
	动物 A的K_m系数

例如，依据体表面积折算法，将化合物用于小鼠的剂量20 mg/kg 换算成大鼠的剂量，需要将20 mg/kg 乘以小鼠的K_m系数（3），再除以大鼠的K_m系数（6），得到化合物用于大鼠的等效剂量为10 mg/kg。

储存条件

2-8°C

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

符号	GHS07
信号词	Warning
危害声明	H302
危害码 (欧洲)	Xn
风险声明 (欧洲)	R22
安全声明 (欧洲)	S2-S45
危险品运输编码	NONH for all modes of transport

1. 物质的识别

产品名：	Ginsenoside-Rd
CAS号：	52705-93-8
制造商/供应商：	西域试剂网站：www.hzbp.cn 邮件：13911702513@139.com

2. 合成/成分数据

产品名：	Ginsenoside-Rd
别名：	Gypenoside VIII
分子式：	C48H82O18
分子量：	947.15

3. 急救措施

吸入后：	如果吸入，移至空气新鲜处，如果呼吸困难，给输氧，如呼吸停止，给予人工呼吸。
皮肤接触后：	用大量的水冲洗，移除污染的衣服和鞋子。
眼睛接触后：	检查并取下隐形眼镜，并用大量的水冲洗；呼叫医生。
吞食后：	如果吞食，用大量纯净水漱口；呼叫医生。

4. 消防措施

适当的灭火剂：	雾状水，二氧化碳，干粉或泡沫。
防护设备：	穿戴自给式呼吸器和防护服，以防止与皮肤和眼睛接触。

5. 泄漏应急处理

安全防范措施：	封锁泄漏区域；穿戴自给式呼吸器，防护服和厚橡胶手套。
清洁/收集措施：	使用液体粘合原料（硅藻土，通用粘合剂）吸取精细粉末；使用酒精擦洗表面和设备除去污渍；根据第11条处理被污染的材料。

6. 处理和储存

安全处理说明：	避免吸入和接触皮肤，眼睛及衣物；材料可能略微具有刺激性。
储存：	粉末型式 -20°C 3年；4°C 2年溶于溶剂 -80°C 6个月；-20°C 1个月

7. 接触控制和个人防护

呼吸设备：	NIOSH / MSHA认可的呼吸器。
双手保护：	耐化学腐蚀的橡胶手套。
眼睛防护：	化学安全护目镜。

8. 稳定性和反应活性

稳定性：	按照说明存储是稳定的；避免强氧化剂。
热分解/其他要避免的情况：	避免光和热。

9. 毒性资料

急性毒性：	无可用资料。
主要刺激性影响：	无可用资料。
在皮肤上：	无可用资料。
对眼睛：	无可用资料；可能具有刺激性。

10. 生态资料

一般注意事项：

无可用资料。

11. 废弃处置

按照所在国家，省份，县市和地方的法规处置。

12. 运输信息

正确的运输名称：	无
非危险品运输：	这种物质被视为非危险品运输。

13. 法规信息

尚未有针对此产品作出的化学安全性评估。

14. 其他信息

88140-39-0

52705-93-8

文献：Kitagawa; Taniyama; Yoshikawa; Ikenishi; Nakagawa Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 11 p. 2961 - 2970

88140-37-8

52705-93-8

文献：Kitagawa; Taniyama; Yoshikawa; Ikenishi; Nakagawa Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 11 p. 2961 - 2970

88140-34-5

52705-93-8

文献：Kitagawa; Taniyama; Yoshikawa; Ikenishi; Nakagawa Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 11 p. 2961 - 2970

88140-38-9

52705-93-8

文献：Kitagawa; Taniyama; Yoshikawa; Ikenishi; Nakagawa Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 11 p. 2961 - 2970

上游产品 4
88140-39-0 88140-37-8 88140-34-5 88140-38-9
下游产品 0

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