Melphalan L-PAM|cas:148-82-3|西域试剂

Melphalan L-PAM,95.96%

产品编号：Bellancom-17575| CAS NO：148-82-3| 分子式：C₁₃H₁₈Cl₂N₂O₂| 分子量：305.20

Melphalan 是一种有效的 DNA 烷化剂 (DNA alkylator)，具有抗肿瘤活性。

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货号	价格	库存与货期
Bellancom-17575	￥520.00	杭州北京（现货）
Bellancom-17575	￥780.00	杭州北京（现货）
Bellancom-17575	￥3150.00	杭州北京（现货）

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Melphalan L-PAM

产品介绍

Melphalan 是一种有效的 DNA 烷化剂 (DNA alkylator)，具有抗肿瘤活性。

生物活性

Melphalan is an effective DNA alkylating agent, with potent antitumor activity.

体外研究

Melphalan is a DNA alkylating agent, used for multiple myeloma. Melphalan-DNA adducts can be visualised in both cultured cells and solid tumour tissue.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Melphalan (12 mg/kg, i.p.) increases pharmacological activity with heat in SD rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Melphalan (12 mg/kg, i.p.) increases pharmacological activity with heat in SD rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 5 mg/mL (16.38 mM; Need ultrasonic)

H₂O : 4 mg/mL (13.11 mM; ultrasonic and adjust pH to 2 with HCl)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.2765 mL	16.3827 mL	32.7654 mL
5 mM	0.6553 mL	3.2765 mL	6.5531 mL
10 mM	0.3277 mL	1.6383 mL	3.2765 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献

. BLUMBERG BS, et al. AN ALKYLATING AGENT FOR MULTIPLE MYELOMA: MELPHALAN. JAMA. 1965 Feb 15;191:547-9. [Content Brief]

. Glehen O, et al. Hyperthermia modifies pharmacokinetics and tissue distribution of intraperitoneal melphalan in a rat model. Cancer Chemother Pharmacol. 2004 Jul;54(1):79-84. [Content Brief]

. Rothbarth J, et al. Immunohistochemical detection of melphalan-DNA adducts in colon cancer cells in vitro and human colorectal liver tumours in vivo. Biochem Pharmacol. 2004 May 1;67(9):1771-8. [Content Brief]

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