β-Carotene β-胡萝卜素; Provitamin A; beta-Carotene|cas:7235-40-7|西域试剂

β-Carotene β-胡萝卜素; Provitamin A; beta-Carotene,98.0%

产品编号：Bellancom-N0411| CAS NO：7235-40-7| 分子式：C₄₀H₅₆| 分子量：536.87

β-Carotene (Provitamin A) 属于类胡萝卜素化合物，是天然存在的维生素 A 前体。β-Carotene 是一种 ROS 调节剂，具有抗氧化和抗炎活性。β-Carotene 可作为抗氧化剂或者促氧化剂，取决于它的内在特性以及它所作用的生物环境的氧化还原电位。 β-Carotene 可诱导乳腺癌细胞凋亡 (apoptosis)，具有抗癌活性。

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-N0411		￥500.00	杭州北京（现货）
Bellancom-N0411		￥800.00	杭州北京（现货）

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β-Carotene β-胡萝卜素; Provitamin A; beta-Carotene

产品介绍

β-Carotene (Provitamin A) 属于类胡萝卜素化合物，是天然存在的维生素 A 前体。β-Carotene 是一种 ROS 调节剂，具有抗氧化和抗炎活性。β-Carotene 可作为抗氧化剂或者促氧化剂，取决于它的内在特性以及它所作用的生物环境的氧化还原电位。 β-Carotene 可诱导乳腺癌细胞凋亡 (apoptosis)，具有抗癌活性。

生物活性

β-Carotene (Provitamin A), a carotenoid compound, is a naturally-occurring vitamin A precursor. β-Carotene is a modulator of reactive oxygen species (ROS), with antioxidant and antiinflammatory activities. β-Carotene may serve as an antioxidant or as a prooxidant, depending on its intrinsic properties as well as on the redox potential of the biological environment in which it acts. β-Carotene induces breast cancer cells apoptosis, with anticancer activities^[4]^[5].

体外研究

β-Carotene up-regulates PPAR-γ expression and ROS production in MCF-7 cancer cells.
β-Carotene (1-100 μM; 72 hours) remarkably decreases the survival of MCF-7 cells in a dose-dependent manner.
β-Carotene (50 μM; 24-72 hours) significantly enhances the expression levels of PPAR-γ mRNA and protein in a time-dependent manner.
β-Carotene down-regulates the COX-2 but up-regulates the p21 mRNA level and protein expression in a time dependent manner.
β-Carotene significantly increases the percentage of early apoptosis and the effect was partly attenuated by pre-incubation with GW9662 (HY-16578) or GSH (HY-D0187).
β-Carotene induces cytochrome C release.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[5]

Cell Line:	MCF-7 cells
Concentration:	1 μM, 10 μM, 20 μM, 50 μM, 100 μM
Incubation Time:	72 hours
Result:	Decreased the numbers of viable cells to 70% and 50% at 20 μM and 50 μM, respectively.

RT-PCR^[5]

Cell Line:	MCF-7 cells
Concentration:	50 μM
Incubation Time:	24 hours, 48 hours, 72 hours
Result:	Up-regulated the PPAR-γ mRNA.

Western Blot Analysis^[5]

Cell Line:	MCF-7 cells
Concentration:	50 μM
Incubation Time:	24 hours, 48 hours, 72 hours
Result:	Up-regulated PPAR-γ protein expression levels.

Apoptosis Analysis^[5]

Cell Line:	MCF-7 cells
Concentration:	50 μM
Incubation Time:	72 hours
Result:	Induced MCF-7 cells apoptosis.

分子量

536.87

性状

Solid

Formula

C₄₀H₅₆

CAS 号

7235-40-7

中文名称

β-胡萝卜素

结构分类

Terpenoids
Other Terpenoids

初始来源

Plants
other families

体内研究

性状

Solid

溶解性数据

In Vitro:

THF : 12.5 mg/mL (23.28 mM; ultrasonic and warming and heat to 60°C)

Acetone : 5 mg/mL (9.31 mM; Need ultrasonic)

DMSO : 1 mg/mL (1.86 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.8626 mL	9.3132 mL	18.6265 mL
5 mM	0.3725 mL	1.8626 mL	3.7253 mL
10 mM	0.1863 mL	0.9313 mL	1.8626 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

参考文献

. Tanumihardjo, S.A., Factors influencing the conversion of carotenoids to retinol: bioavailability to bioconversion to bioefficacy. Int J Vitam Nutr Res, 2002. 72(1): p. 40-5. [Content Brief]

. Leo, M.A., et al. Alcohol, vitamin A, and beta-carotene: adverse interactions, including hepatotoxicity and carcinogenicity. Am J Clin Nutr, 1999. 69(6): p. 1071-85. [Content Brief]

. Yanhong Cui, et al. beta-Carotene induces apoptosis and up-regulates peroxisome proliferator-activated receptor gamma expression and reactive oxygen species production in MCF-7 cancer cells. Eur J Cancer. 2007 Nov;43(17):2590-601. [Content Brief]

[4]. AKIFUMI KAWATA, et al. Anti-inflammatory Activity of β-Carotene, Lycopene and Tri-n-butylborane, a Scavenger of Reactive Oxygen Species. In Vivo. 2018 Mar-Apr; 32(2): 255-264. [Content Brief]

[5]. Paola Palozza, et al. Prooxidant effects of beta-carotene in cultured cells. Mol Aspects Med. 2003 Dec;24(6):353-62. [Content Brief]

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

产品编号(Item Number)

批号(Lot Number)

补充危害声明	Risk of explosion if heated under confinement.
个人防护装备	Eyeshields;Gloves
危害码 (欧洲)	Xn: Harmful;
风险声明 (欧洲)	R44
安全声明 (欧洲)	S7-S15-S18
危险品运输编码	NONH for all modes of transport
WGK德国	1
RTECS号	FI0329500
包装等级	II; III
危险类别	4.1
海关编码	2932999099

1. 物质的识别

产品名：	β-Carotene
CAS号：	7235-40-7
制造商/供应商：	西域试剂网站：www.hzbp.cn 邮件：13911702513@139.com

2. 合成/成分数据

产品名：	β-Carotene
别名：	Provitamin A; Carotaben; beta-Carotene; Lucarotin
分子式：	C40H56
分子量：	536.87

3. 急救措施

吸入后：	如果吸入，移至空气新鲜处，如果呼吸困难，给输氧，如呼吸停止，给予人工呼吸。
皮肤接触后：	用大量的水冲洗，移除污染的衣服和鞋子。
眼睛接触后：	检查并取下隐形眼镜，并用大量的水冲洗；呼叫医生。
吞食后：	如果吞食，用大量纯净水漱口；呼叫医生。

4. 消防措施

适当的灭火剂：	雾状水，二氧化碳，干粉或泡沫。
防护设备：	穿戴自给式呼吸器和防护服，以防止与皮肤和眼睛接触。

5. 泄漏应急处理

安全防范措施：	封锁泄漏区域；穿戴自给式呼吸器，防护服和厚橡胶手套。
清洁/收集措施：	使用液体粘合原料（硅藻土，通用粘合剂）吸取精细粉末；使用酒精擦洗表面和设备除去污渍；根据第11条处理被污染的材料。

6. 处理和储存

安全处理说明：	避免吸入和接触皮肤，眼睛及衣物；材料可能略微具有刺激性。
储存：	-20°C, protect from light, dry, sealed

7. 接触控制和个人防护

呼吸设备：	NIOSH / MSHA认可的呼吸器。
双手保护：	耐化学腐蚀的橡胶手套。
眼睛防护：	化学安全护目镜。

8. 稳定性和反应活性

稳定性：	按照说明存储是稳定的；避免强氧化剂。
热分解/其他要避免的情况：	避免光和热。

9. 毒性资料

急性毒性：	无可用资料。
主要刺激性影响：	无可用资料。
在皮肤上：	无可用资料。
对眼睛：	无可用资料；可能具有刺激性。

10. 生态资料

一般注意事项：

无可用资料。

11. 废弃处置

按照所在国家，省份，县市和地方的法规处置。

12. 运输信息

正确的运输名称：	无
非危险品运输：	这种物质被视为非危险品运输。

13. 法规信息

尚未有针对此产品作出的化学安全性评估。

14. 其他信息

上游产品 9
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下游产品 10
514-78-3 991-90-2 17092-92-1 7500-42-7
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